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Search · four archives
16 papers · ranked by Valyu relevance
Anatoli Y. Kabakov, Elif Sengun, Yichun Lu, Karim Roder + 5 more
Cardiac arrhythmias significantly contribute to cardiovascular morbidity and mortality. The rabbit heart serves as an accepted model system for studying cardiac cell excitation and arrhythmogenicity. Accordingly, primary cultures of adult rabbit ventricular cardiomyocytes serve as a preferable model to study molecular…
Márta Ágoston, Zsófia Kohajda, László Virág, Beáta Baláti + 10 more
'Norbert Nagy' 'Csaba Lengyel' 'Miklós Bitay' 'Gábor Bogáts' 'András Vereckei' 'Julius Gy. Papp' 'András Varró' 'Norbert Jost' 'Dinender K. Singla' 'Kelong Fan'] To understand the large inter-species variations in drug effects on repolarization, the properties of the rapid (IKr) and the slow (IKs) components of the…
Briana M. Bohannon, Jessica J. Jowais, Leif Nyberg, Sara I. Liin + 1 more
Voltage-gated potassium (K_V_) channels are important regulators of cellular excitability and control action potential repolarization in the heart and brain. K_V_ channel mutations lead to disordered cellular excitability. Loss-of-function mutations, for example, result in membrane hyperexcitability, a characteristic…
Julian A. Schreiber, Melina Möller, Mark Zaydman, Lu Zhao + 15 more
Loss-of-function mutations in Kv7.1 often lead to long QT syndrome (LQTS), a cardiac repolarization disorder associated with arrhythmia and subsequent sudden cardiac death. The discovery of agonistic I*Ks modulators may offer a new potential strategy in pharmacological treatment of this disorder. The benzodiazepine…
Tadashi Nakajima, Shuntaro Tamura, Reika Kawabata-Iwakawa, Hideki Itoh + 11 more
'Hideki Itoh' 'Hiroshi Hasegawa' 'Takashi Kobari' 'Shun Harasawa' 'Akiko Sekine' 'Masahiko Nishiyama' 'Masahiko Kurabayashi' 'Keiji Imoto' 'Yoshiaki Kaneko' 'Yosuke Nakatani' 'Minoru Horie' 'Hideki Ishii'] Introduction KCNQ1 and KCNE1 form slowly activating delayed rectifier potassium currents (IKs). Loss-of-function…
Ana I. Fernández-Mariño, Xiao-Feng Tan, Chanhyung Bae, Kate Huffer + 2 more
'Jiansen Jiang' 'Kenton J. Swartz'] The Kv2.1 voltage-activated potassium (Kv) channel is a prominent delayed-rectifier Kv channel in the mammalian central nervous system, where its mechanisms of activation and inactivation are critical for regulating intrinsic neuronal excitability1,2. Here we present structures of…
Alessia Golluscio, Jodene Eldstrom, Jessica J. Jowais, Marta E. Perez-Rodriguez + 5 more
In cardiomyocytes, the KCNQ1/KCNE1 channel complex mediates the slow delayed-rectifier current (IKs), pivotal during the repolarization phase of the ventricular action potential. Mutations in IKs cause Long QT Syndrome (LQTS), a syndrome with a prolonged QT interval on the ECG, which increases the risk of ventricular…
Hannah R Martin, Anna Lysakowski, Ruth Anne Eatock, Andrew J King + 1 more
'Andrew J King'] In amniotes, head motions and tilt are detected by two types of vestibular hair cells (HCs) with strikingly different morphology and physiology. Mature type I HCs express a large and very unusual potassium conductance, gK,L, which activates negative to resting potential, confers very negative resting…
Hannah R. Martin, Anna Lysakowski, Ruth Anne Eatock
In amniotes, head motions and tilt are detected by two types of vestibular hair cells (HCs) with strikingly different morphology and physiology. Mature type I HCs express a large and very unusual potassium conductance, gK,L, which activates negative to resting potential, confers very negative resting potentials and low…
Hannah R. Martin, Anna Lysakowski, Ruth Anne Eatock
In amniotes, head motions and tilt are detected by two types of vestibular hair cells (HCs) with strikingly different morphology and physiology. Mature type I HCs express a large and very unusual potassium conductance, g_K,L_, which activates negative to resting potential, confers very negative resting potentials and…
Muhammed Ikbal Sönmez, Silvana Goldack, Elina Nurkkala, Carl Schulz + 6 more
Biophysical properties of IKs were measured by rectangular voltage step protocols with very positive test pulse potentials and very long test pulse durations. We have used such an approach to better compare our results to findings from the literature (see above). However, contribution of IKs to repolarization depends…
Candido Cabo
A pharmacological approach to prevent reentrant tachycardias is to prolong the action potential duration (APD) of the myocytes that provide the substrate for the arrhythmia. For such an anti-arrhythmic approach to be effective, APD prolongation should be positive rate dependent, that is, it should maximize APD…
Yichun Lin, Jerome J. Lacroix, James D. Sterling, Yun Lyna Luo
Rectification, the tendency of bidirectional ionic conductors to favor ion flow in a specific direction, is an intrinsic property of many ion channels and synthetic nanopores. Despite its frequent occurrence in ion channels and its phenomenological explanation using Eyring’s rate theory, a quantitative relationship…
Anaëlle De Worm, Guillaume Drion, Pierre Sacré
promote robust and physiological bistability Authors: ['Anaëlle De Worm' 'Guillaume Drion' 'Pierre Sacré'] Abbreviated title (50 character max): Kir and Ca channels promote robust bistability Author Names and Affiliations: Anaelle De Worm ¨ 1 , Guillaume Drion1,∗ , Pierre Sacre´ 1,∗ 1Department of Electrical…
Predrag Janjic, Dimitar Solev, Ljupčo Kocarev
- Despite the molecular evidence that the nearly linear steady-state current-voltage relationship in mammalian astrocytes reflects a total current resulting from more than one differently regulated + conductances, detailed ODE models of membrane voltage are still lacking. Repeated experimental results of deregulated…
Mark G. M. Aarts, Willem Boon, Blaise Cuénod, M. Dijkstra + 2 more
'René van Roij' 'Esther Alarcón‐Lladó'] Fluidic devices exhibiting ion current rectification (ICR), or ionic diodes, are of broad interest for applications including desalination, energy harvesting, and sensing, amongst others. For such applications a large conductance is desirable which can be achieved by…