23 papers · ranked by Valyu relevance
Jyothi Arikkath
Dendrites are key integrators of synaptic information in neurons and play vital roles in neuronal plasticity. Hence, it is necessary that dendrite arborization is precisely controlled and coordinated with synaptic activity to ensure appropriate functional neural network integrity. In the past several years, it has…
Roman Makarov, Michalis Pagkalos, Panayiota Poirazi
- Dendrites optimize information processing and storage under resource constraints. - Compartmentalization in dendrites is a key to enhance computational efficiency. - Dendrites facilitate predictive, context-dependent processing in hierarchical networks. - Dendritic nonlinearities might have evolved to process natural…
Spyridon Chavlis, Panayiota Poirazi
This article highlights specific features of biological neurons and their dendritic trees, whose adoption may help advance artificial neural networks used in various machine learning applications. Advancements could take the form of increased computational capabilities and/or reduced power consumption. Proposed…
Jan H. Kirchner, Lucas Euler, Julijana Gjorgjieva
Dendritic branching and synaptic organization shape single neuron and network computations. How they emerge simultaneously during brain development as neurons become integrated into functional networks is still not mechanistically understood. Here, we propose a computational model in which dendrite growth and the…
Mohammad I. K. Hamad, Bright Starling Emerald, Kukkala K. Kumar, Marwa F. Ibrahim + 2 more
'Marwa F. Ibrahim' 'Bassam R. Ali' 'Mo’ath F. Bataineh'] Proper growth and branching of dendrites are crucial for adequate central nervous system (CNS) functioning. The neuronal dendritic geometry determines the mode and quality of information processing. Any defects in dendrite development will disrupt neuronal…
Kotaro Furusawa, Kazuo Emoto
Dendrites are cellular structures essential for the integration of neuronal information. These elegant but complex structures are highly patterned across the nervous system but vary tremendously in their size and fine architecture, each designed to best serve specific computations within their networks. Recent in vivo…
Jan H. Kirchner, Julijana Gjorgjieva
Single neurons in the brain exhibit astounding computational capabilities, which gradually emerge throughout development and enable them to become integrated into complex neural circuits. These capabilities derive in part from the precise arrangement of synaptic inputs on the neurons’ dendrites. While the full…
Daniel J. Mannion
Sophisticated machine learning struggles to transition onto battery-operated devices due to the high-power consumption of neural networks. Researchers have turned to neuromorphic engineering, inspired by biological neural networks, for more efficient solutions. While previous research focused on artificial neurons and…
Amrutha Palavalli, Nicolás Tizón-Escamilla, Jean-François Rupprecht, Thomas Lecuit
Dendrite morphology is necessary for the correct integration of inputs that neurons receive. The branching mechanisms allowing neurons to acquire their type-specific morphology remain unclear. Classically, axon and dendrite patterns were shown to be guided by molecules providing deterministic cues. However, the extent…
Daniel J. Mannion, Anthony J. Kenyon
Bioinspired computing has focused on neurons and synapses with great success. However, the connections between these, the dendrites, also play an important role. In this paper, we investigate the motivation for replicating dendritic computation and present a framework to guide future attempts in their construction. The…
Sydney E. Prange, Isha N. Bhakta, Daria Sysoeva, Grace E. Jean + 6 more
Dendrite defects and loss are early cellular alterations observed across neurodegenerative diseases that play a role in early disease pathogenesis. Dendrite degeneration can be modeled by expressing pathogenic polyglutamine disease transgenes in Drosophila neurons in vivo. Here, we show that we can protect against…
Erin N. Lottes, Daniel N. Cox
Cellular protein homeostasis, or proteostasis, is indispensable to the survival and function of all cells. Distinct from other cell types, neurons are long-lived, exhibiting architecturally complex and diverse multipolar projection morphologies that can span great distances. These properties present unique demands on…
Cole D. Fincher, Christos E. Athanasiou, Colin Gilgenbach, Michael Wang + 3 more
Metal dendrite penetration is a mode of electrolyte failure that threatens the viability of metal anode based high energy solid-state batteries. Whether dendrites are driven by mechanical failure or electrochemical degradation of solid electrolytes remains an open question. If internal mechanical forces drive failure…
Christopher Brian Currin, Joseph Valentino Raimondo
Many neurons in the mammalian central nervous system have complex dendritic arborisations and active dendritic conductances that enable these cells to perform sophisticated computations. How dendritically targeted inhibition affects local dendritic excitability is not fully understood. Here we use computational models…
Authors not listed
Lithium metal solid-state batteries offer advantages of high energy density and improved safety compared with lithium ion batteries. However, solid-state batteries fail through short-circuiting even at low charging rates (<1 mA/cm2) due to lithium dendrite initiation and propagation. The location of dendrite initiation…
Anthony Moreno-Sanchez, Alexander N. Vasserman, HyoJong Jang, Bryce W. Hina + 2 more
Synapses are often precisely organized on dendritic arbors, yet the role of synaptic topography in dendritic integration remains poorly understood. Utilizing electron microscopy (EM) connectomics we investigate synaptic topography in Drosophila melanogaster looming circuits, focusing on retinotopically tuned visual…
Jacopo Meldolesi, Bruno Meloni
Brain synapses are neuronal structures of the greatest interest. For a long time, however, the knowledge about them was variable, and interest was mostly focused on their pre-synaptic portions, especially neurotransmitter release from axon terminals. In the present review interest is focused on post-synapses, the…
Lotfi Ferhat
Several neurological disorders characterized by cognitive deficits, including Alzheimer's disease, down syndrome, and epilepsy exhibit abnormal spine density and/or morphology. Actin-based cytoskeleton network dynamics is critical for the regulation of spine morphology and synaptic function. In this paper, I consider…
Fabian H. Kreten, Barbara A. Niemeyer, Ludger Santen, Reza Shaebani
First-Passage Analysis Authors: ['Fabian H. Kreten' 'Barbara A. Niemeyer' 'Ludger Santen' 'Reza Shaebani'] A high degree of structural complexity arises in dynamic neuronal dendrites due to extensive branching patterns and diverse spine morphologies, which enable the nervous system to adjust function, construct complex…
Bas van Bommel, Anja Konietzny, Oliver Kobler, Julia Bär + 1 more
Organelle positioning within neurites is required for proper neuronal function. In dendrites with their complex cytoskeletal organization, transport of organelles is guided by local specializations of the microtubule and actin cytoskeleton, and by coordinated activity of different motor proteins. Here, we focus on the…
Katarina Cicvarić, Leon Merker, Bojing Zhang, Miran Gaberšček + 1 more
Anode-free Li-metal batteries offer high energy density but are prone to dendrite formation during charging which can cause catastrophic failures. Ensuring dendrite-free smooth Li deposits during charging is therefore necessary. Suppressing dendrite growth can be achieved by pulsed current charging, especially during…
wenzhong liu, hualan li
Infection with the Zika virus results in severe neurological disease in adults or congenital Zika syndrome in newborns. We employed the domain search strategy to study the Zika virus glycoprotein E in this work. The results revealed that immature E contains a NGF domain…
Yu Shen
Alzheimer's disease (AD) is a neurodegenerative disorder that affects millions of people worldwide. Early screening is crucial to prevent potential damages, and researchers are exploring alternative approaches such as multiplexed assays and emerging technologies such as microfluidics, nanotechnology, and biosensors.…