25 papers · ranked by Valyu relevance
Jan H. Kirchner, Lucas Euler, Julijana Gjorgjieva
Dendritic branching and synaptic organization shape single neuron and network computations. How they emerge simultaneously during brain development as neurons become integrated into functional networks is still not mechanistically understood. Here, we propose a computational model in which dendrite growth and the…
Ryan Rahy, Lothar Baltruschat, André Ferreira Castro, Peter Jedlicka + 2 more
Circuit connectivity and computation depend on how dendrites branch and occupy space within neural tissue. While optimal wiring principles have long been known to constrain dendritic morphology and their scaling behaviour, the growth dynamics that produce such optimised structures remain unclear. Leveraging structural…
Ane Goikolea-Vives, Helen B. Stolp, Giuseppe Lazzarino
Neurodevelopmental disorders can derive from a complex combination of genetic variation and environmental pressures on key developmental processes. Despite this complex aetiology, and the equally complex array of syndromes and conditions diagnosed under the heading of neurodevelopmental disorder, there are parallels in…
Laura Moreno-Velasquez, Hung Lo, Stephen Lenzi, Malte Kaehne + 4 more
Dendritic geometry is largely determined during postnatal development and has a substantial impact on neural function. In sensory processing, postnatal development of the dendritic tree is affected by two dominant circuit motifs, ascending sensory feedforward inputs and descending and local recurrent connections. In…
Jyothi Arikkath
Dendrites are key integrators of synaptic information in neurons and play vital roles in neuronal plasticity. Hence, it is necessary that dendrite arborization is precisely controlled and coordinated with synaptic activity to ensure appropriate functional neural network integrity. In the past several years, it has…
Lothar Baltruschat, Gaia Tavosanis, Hermann Cuntz
The way in which dendrites spread within neural tissue determines the resulting circuit connectivity and computation. However, a general theory describing the dynamics of this growth process does not exist. Here we obtain the first time-lapse reconstructions of neurons in living fly larvae over the entirety of their…
Andrew Nugent, Karen M. Page, Alexey Zaikin, Laura C. Andreae
Neurons receive information through their dendrites. During development, when synaptic connections are forming, dendrites grow, retract, and branch. The resulting dendritic tree shapes the structure of the broader neural network. Crucially, retraction and branching make it necessary to track whole dendritic paths…
Laura Moreno-Velasquez, Hung Lo, Stephen Lenzi, Malte Kaehne + 4 more
'Jörg Breustedt' 'Dietmar Schmitz' 'Sten Rüdiger' 'Friedrich W. Johenning'] Title: Abstract Dendritic geometry is largely determined during postnatal development and has a substantial impact on neural function. In sensory processing, postnatal development of the dendritic tree is affected by two dominant circuit…
Pablo García-López, Virginia García-Marín, Miguel Freire
Dendritic spines receive the majority of excitatory connections in the central nervous system, and, thus, they are key structures in the regulation of neural activity. Hence, the cellular and molecular mechanisms underlying their generation and plasticity, both during development and in adulthood, are a matter of…
André Ferreira Castro, Lothar Baltruschat, Tomke Stürner, Amirhoushang Bahrami + 3 more
Class I ventral posterior dendritic arborisation (c1vpda) proprioceptive sensory neurons respond to contractions in the Drosophila larval body wall during crawling. Their dendritic branches run along the direction of contraction, possibly a functional requirement to maximise membrane curvature during crawling…
Kotaro Furusawa, Kazuo Emoto
Dendrites are cellular structures essential for the integration of neuronal information. These elegant but complex structures are highly patterned across the nervous system but vary tremendously in their size and fine architecture, each designed to best serve specific computations within their networks. Recent in vivo…
Célia Biane, Florian Rückerl, Therese Abrahamsson, Cécile Saint-Cloment + 5 more
Synaptic transmission, connectivity, and dendritic morphology mature in parallel during brain development and are often disrupted in neurodevelopmental disorders. Yet how these changes influence the neuronal computations necessary for normal brain function are not well understood. To identify cellular mechanisms…
Kazuto Fujishima, Junko Kurisu, Midori Yamada, Mineko Kengaku
The mechanism underlying the geometrical patterning of axon and dendrite wiring remains elusive, despite its critical importance in the formation of functional neural circuits. Cerebellar Purkinje cell (PC) arborizes a typical planar dendrite, which forms an orthogonal network with granule cell (GC) axons. By using…
Celia Biane, Florian Rückerl, Therese Abrahamsson, Cécile Saint-Cloment + 7 more
'Cécile Saint-Cloment' 'Jean Mariani' 'Ryuichi Shigemoto' 'David A DiGregorio' 'Rachel M Sherrard' 'Laurence Cathala' 'Linda Overstreet-Wadiche' 'John R Huguenard'] Synaptic transmission, connectivity, and dendritic morphology mature in parallel during brain development and are often disrupted in neurodevelopmental…
William B. Levy, Robert A. Baxter
Neocortical pyramidal neurons have many dendrites, and such dendrites are capable of, in isolation of oneanother, generating a neuronal spike. It is also now understood that there is a large amount of dendritic growth during the first years of a humans life, arguably a period of prodigious learning. These observations…
Spyridon Chavlis, Panayiota Poirazi
This article highlights specific features of biological neurons and their dendritic trees, whose adoption may help advance artificial neural networks used in various machine learning applications. Advancements could take the form of increased computational capabilities and/or reduced power consumption. Proposed…
Zhi-Song lv, Chen-Ping Zhu, Pei Nie, Jing Zhao + 3 more
'Yanjun Wang' 'Chin‐Kun Hu'] The distribution of the geometric distances of connected neurons is a practical factor underlying neural networks in the brain. It can affect the brain´s dynamic properties at the ground level. Karbowski derived a power-law decay distribution that has not yet been verified by experiment. In…
Authors not listed
Lithium metal solid-state batteries offer advantages of high energy density and improved safety compared with lithium ion batteries. However, solid-state batteries fail through short-circuiting even at low charging rates (<1 mA/cm2) due to lithium dendrite initiation and propagation. The location of dendrite initiation…
Saeed Aljaberi, Timothy O’Leary, Fulvio Forni
— Neuronal circuits internally regulate electrical signaling via a host of homeostatic mechanisms. Two prominent mechanisms, synaptic scaling and structural plasticity, are believed to maintain average activity within an operating range by modifying the strength and spatial extent of network connectivity using negative…
Søren Leth Mejlsøe, Johannes Fabritius Petersen, Jørn Bolstad Christensen
In this paper, we present for the first time a general scalable, synthetic scheme that allows control over the position and number of different surface groups on PAMAM-dendrimers. The methodology is based on synthesis of small AB2-building blocks and cores having orthogonal protective groups allowing synthesis of…
Authors not listed
Understanding and controlling the microstructure of zinc (Zn) metal electrodeposits is critical for advancing the next generation of rechargeable Zn batteries. In this study, we develop microelectrode arrays to systematically investigate the relationship between current density, morphology, and Coulombic efficiency…
Xiaoting Xue, Helena Persson, Lei Ye
Accurate and rapid detection of nucleic acid sequences is of utmost importance in various fields, including disease monitoring, clinical treatment, gene analysis and drug discovery. In this study, we developed a "turn-on" fluorescence biosensor that enables simple and highly efficient detection of nucleic acid…
Sol Lim, Marcus Kaiser
Early brain connectivity development consists of multiple stages: birth of neurons, their migration and the subsequent growth of axons and dendrites. Each stage occurs within a certain period of time depending on types of neurons and cortical layers. Forming synapses between neurons either by growing axons starting at…
Kazeem Olanrewaju, Ashlee N. Ford Versypt
The human physiological system consists of several biological units carefully organized to engage in a bio-physicochemical interaction with complex fluids transporting nutritional and life-supporting species (oxygen and carbon dioxide) needed for the proper functioning of the body. The nutritional species are products…
wenzhong liu, hualan li
Infection with the Zika virus results in severe neurological disease in adults or congenital Zika syndrome in newborns. We employed the domain search strategy to study the Zika virus glycoprotein E in this work. The results revealed that immature E contains a NGF domain…