21 papers · ranked by Valyu relevance
Kevin Martinez-Anhom, Isaac Salazar-Ciudad
A fundamental question of developmental biology is pattern formation, or how cells with specific gene expression end up in specific locations in the body to form tissues, organs and, overall, functional anatomy. Pattern formation involves communication through extracellular signals and complex intracellular gene…
Paul Gorbow
Throughout mathematics there are constructions where an object is obtained as a limit of an infinite sequence. Typically, the objects in the sequence improve as the sequence progresses, and the ideal is reached at the limit. I introduce a view that understands this as a development process by which a dynamic…
Aleksandra Łuczak, Klara Cermakova, Sławomir Kalinowski, Eduard Hromada + 2 more
'Eduard Hromada' 'Oskar Szczygieł' 'Miguel Alves Pereira'] Sustainable development and standard of living of households have recently become central topics in economic analysis, scientific research, and public debate. This study aims to evaluate the positions of European Union (EU) countries and the changes occurring…
Mauricio González-Forero, Andy Gardner
Natural selection acts on developmentally constructed phenotypes, raising the question of how development affects evolution. A mathematical framework that explicitly integrates development into evolution has recently been derived. Here we use this framework to analyse how development affects evolution. We show that…
Ksenia Chmutina, Jason von Meding, Vicente Sandoval, Michael Boyland + 7 more
'Giuseppe Forino' 'Wesley Cheek' 'Darien Alexander Williams' 'Claudia Gonzalez-Muzzio' 'Isabella Tomassi' 'Holmes Páez' 'Victor Marchezini'] The Sendai Framework for Disaster Risk Reduction 2015−2030’s (SFDRR) framing moved away from disaster risk as a natural phenomenon to the examination of the inequality and…
Tania Zittoun, Oliver Clifford Pedersen, Alex Gillespie, Nathalie Muller Mirza + 1 more
Crises are everywhere - from environmental collapses, wars, and skyrocketing inequalities to ageing populations and pandemics, yet there is no universal way that individuals respond to these. What can be said about these? This is an invitation for us, loosely defined as social, cultural and developmental psychologists…
Erin Looney, Andre Buscariolli, Maria Yang, Geoffrey Raymond + 2 more
Hardware-based startups risk having longer times-to-market, deterring investment in critical fields such as cleantech, medical devices, and automation. We interviewed 55 leaders at hardware startups, mapped their development timelines, and found prototyping to be the longest development step (median of 19 weeks per…
Sabine Pirchio, Blanca Silvia Fraijo Sing, Ylenia Passiatore
Child development consists of a series of changes that occur in the individual, driven by genetic, biological, social, cultural, and environmental resources and constraints (Bronfenbrenner, [2]; Hendry and Kloep, [13]). Child development has been described and explained through different perspectives, focusing on the…
Brady K. Quinn
Whether arthropod development is generally isochronal or equiproportional was tested Developmental proportions of most species’ stages varied with temperature Many species had ‘mixed’ development between variable and equiproportional types The general occurrence of isochronal and equiproportional development was…
Cristina Tănăsescu, Amelia Bucur, Camelia Oprean-Stan
Sustainable Development Authors: ['Cristina Tănăsescu' 'Amelia Bucur' 'Camelia Oprean-Stan'] One of the themes that have been approached more and more within the specialised literature is being represented by economic cycles. The analysis of these is very useful in the long term predictions, in finding solutions for…
Santiago Oliveros
We introduce a dynamic model in which a developer incrementally improves a product of uncertain quality over time, with the quality evolving as a controlled Brownian motion. At each moment in time, the developer can continue exploring by paying a flow cost, restart from a previously attained quality level by paying a…
David V. Day, Laura Dannhäuser, A. Rui Gomes, Catarina Morais + 1 more
'Gianluca Serafini'] We argue for reconsidering leadership development based on open systems theory and systems design principles. A primary advantage of open systems thinking is that it encourages holistic approaches to development and avoids episodic program-based training and piecemeal thinking. The latter…
Philippe Kruchten
We propose a conceptual model of software development that encompasses all approaches: traditional or agile, light and heavy, for large and small development efforts. The model identifies both the common aspects in all software development, i.e., elements found in some form or another in each and every software…
Іvan V. Kazachkov
Investigation of the critical levels and catastrophes in the complex systems of different nature is useful and perspective. Mathematical modeling and analysis is presented for revealing and investigation of the phenomena and critical levels in a development of complex systems for various natures associated with diverse…
Lucas Gren
—Brooks' Law is often referred to in practice and states that adding manpower to a late software project makes it even later. Brooks' himself gave three explanation only related to concrete task-related issues, like introducing new members to the work being done, communication overheads, or difficulty dividing some…
Brady K. Quinn
Temperature-dependent development influences production rates of economically- and ecologically-important arthropod species, including crustaceans important to fisheries and agricultural pests. Numerous candidate equation types (development functions) exist to describe the effect of temperature on development time, yet…
Jacques A. Deere, Isabel M. Smallegange
Developmental plasticity alters phenotypes and can in that way change the response to selection and affect, and be affected by, population size-structure when alternative phenotypes show different life history trajectories, in an eco-evolutionary interaction. Developmental plasticity often functions to anticipate…
David Snead, Yonghong Gan, Thomas Scattolin, Dinesh Paymode + 11 more
A commercial route to MRTX849 (adagrasib) was developed to support clinical and commercial needs. Yield was improved to 32% over six chemical steps. A doubly regioselective SNAr reduced consumption of an expensive chiral intermediate, reaction optimization led to parts per million palladium catalysis, and a new method…
Christopher Southan
This report covers academic small-molecule drug development with a view to distilling guidelines. The first section covers research productivity feeding into commercial development before reviewing the literature on statistics of academic development It then considers differences between probes and drugs before…
Peter Sagmeister, Lukas Melnizky, Jason Williams, C. Oliver Kappe
In modern pharmaceutical research, the demand for expeditious development of synthetic routes to active pharmaceutical ingredients (APIs) has led to a paradigm shift towards data-rich process development. Conventional methodologies en-compass prolonged timelines for reaction and analytical model developments. Both…
Vyshnavi Karra, Francisco Hung, Hicham Fenniri
A significant challenge in healthcare is providing effective treatments with minimal side effects. This is particularly true in chemotherapies, where side effects can range from nausea to chemo-induced seizures. As a result, the area of nanotechnology can provide targeted drug delivery systems to boost the efficacy of…