21 papers · ranked by Valyu relevance
Mauricio González-Forero, Andy Gardner
Natural selection acts on developmentally constructed phenotypes, raising the question of how development affects evolution. A mathematical framework that explicitly integrates development into evolution has recently been derived. Here we use this framework to analyse how development affects evolution. We show that…
Ksenia Chmutina, Jason von Meding, Vicente Sandoval, Michael Boyland + 7 more
'Giuseppe Forino' 'Wesley Cheek' 'Darien Alexander Williams' 'Claudia Gonzalez-Muzzio' 'Isabella Tomassi' 'Holmes Páez' 'Victor Marchezini'] The Sendai Framework for Disaster Risk Reduction 2015−2030’s (SFDRR) framing moved away from disaster risk as a natural phenomenon to the examination of the inequality and…
Kevin Martinez-Anhom, Isaac Salazar-Ciudad
A fundamental question of developmental biology is pattern formation, or how cells with specific gene expression end up in specific locations in the body to form tissues, organs and, overall, functional anatomy. Pattern formation involves communication through extracellular signals and complex intracellular gene…
Paul Gorbow
Throughout mathematics there are constructions where an object is obtained as a limit of an infinite sequence. Typically, the objects in the sequence improve as the sequence progresses, and the ideal is reached at the limit. I introduce a view that understands this as a development process by which a dynamic…
Santiago Oliveros
We introduce a dynamic model in which a developer incrementally improves a product of uncertain quality over time, with the quality evolving as a controlled Brownian motion. At each moment in time, the developer can continue exploring by paying a flow cost, restart from a previously attained quality level by paying a…
Aleksandra Łuczak, Klara Cermakova, Sławomir Kalinowski, Eduard Hromada + 2 more
'Eduard Hromada' 'Oskar Szczygieł' 'Miguel Alves Pereira'] Sustainable development and standard of living of households have recently become central topics in economic analysis, scientific research, and public debate. This study aims to evaluate the positions of European Union (EU) countries and the changes occurring…
Tania Zittoun, Oliver Clifford Pedersen, Alex Gillespie, Nathalie Muller Mirza + 1 more
Crises are everywhere - from environmental collapses, wars, and skyrocketing inequalities to ageing populations and pandemics, yet there is no universal way that individuals respond to these. What can be said about these? This is an invitation for us, loosely defined as social, cultural and developmental psychologists…
Francisco J. Romero-Expósito, Almudena Moreno-Rivero, Marta Muñoz-Barrera, Sabas García-Sánchez + 7 more
In multicellular organisms, developmental timers integrate internal and external cues to control numerous cellular processes that need to be temporally coordinated. The molting timer and the developmental timer run in parallel during C. elegans development. We reveal a novel state of transient arrest of the molting…
Erin Looney, Andre Buscariolli, Maria Yang, Geoffrey Raymond + 2 more
Hardware-based startups risk having longer times-to-market, deterring investment in critical fields such as cleantech, medical devices, and automation. We interviewed 55 leaders at hardware startups, mapped their development timelines, and found prototyping to be the longest development step (median of 19 weeks per…
Daniel Silver, Thiago H. Silva, Patrick Adler
This paper elaborates a multi-model approach to studying how local scenes change. We refer to this as the "4 D's" of scene change: development, differentiation, defense, and diffusion. Each posits somewhat distinct change processes, and has its own tradition of theory and empirical research, which we briefly review.…
Bing Wang, Tianchi Chen, Abid Rashid Gill
The Sustainable Development Goals (SDGs) adopted by the United Nations in 2015 represent the current perceptions of humans regarding understanding and monitoring development. Achieving all 17 goals simultaneously is unrealistic. Considering the interconnected nature of SDGs, identifying their critical dimensions…
Daniel Sobrido-Cameán, Fernando Claro-Linares, Noelia Ruiz-Gómez, Patricia Rojas-Ríos + 1 more
Precise regulation of developmental timing is essential for coordinated growth and robust development, yet staging remains technically challenging in many model systems. In Drosophila melanogaster, developmental timing has traditionally been assessed using low-throughput or coarse staging methods, limiting insight into…
Cristina Tănăsescu, Amelia Bucur, Camelia Oprean-Stan
Sustainable Development Authors: ['Cristina Tănăsescu' 'Amelia Bucur' 'Camelia Oprean-Stan'] One of the themes that have been approached more and more within the specialised literature is being represented by economic cycles. The analysis of these is very useful in the long term predictions, in finding solutions for…
David V. Day, Laura Dannhäuser, A. Rui Gomes, Catarina Morais + 1 more
'Gianluca Serafini'] We argue for reconsidering leadership development based on open systems theory and systems design principles. A primary advantage of open systems thinking is that it encourages holistic approaches to development and avoids episodic program-based training and piecemeal thinking. The latter…
Jacques A. Deere, Isabel M. Smallegange
Developmental plasticity alters phenotypes and can in that way change the response to selection and affect, and be affected by, population size-structure when alternative phenotypes show different life history trajectories, in an eco-evolutionary interaction. Developmental plasticity often functions to anticipate…
Liao Chang
Recent years have witnessed a growing number of researches on community characterization. In contrast to the large body of researches on the categorical measures (rise or decline) for evaluating the community development, we propose to estimate the community development strength (to which degree the rise or decline…
David Snead, Yonghong Gan, Thomas Scattolin, Dinesh Paymode + 11 more
A commercial route to MRTX849 (adagrasib) was developed to support clinical and commercial needs. Yield was improved to 32% over six chemical steps. A doubly regioselective SNAr reduced consumption of an expensive chiral intermediate, reaction optimization led to parts per million palladium catalysis, and a new method…
Lorenzo Betti, Luca Gallo, J E Wachs, Federico Battiston
From science to industry, teamwork plays a crucial role in knowledge production and innovation. Most studies consider teams as static groups of individuals, thereby failing to capture how the micro-dynamics of collaborative processes and organizational changes determine team success. Here, we leverage fine-grained…
Peter Sagmeister, Lukas Melnizky, Jason Williams, C. Oliver Kappe
In modern pharmaceutical research, the demand for expeditious development of synthetic routes to active pharmaceutical ingredients (APIs) has led to a paradigm shift towards data-rich process development. Conventional methodologies en-compass prolonged timelines for reaction and analytical model developments. Both…
Vyshnavi Karra, Francisco Hung, Hicham Fenniri
A significant challenge in healthcare is providing effective treatments with minimal side effects. This is particularly true in chemotherapies, where side effects can range from nausea to chemo-induced seizures. As a result, the area of nanotechnology can provide targeted drug delivery systems to boost the efficacy of…
Ronald Marquez, Laura Tolosa, Ruben Gomez, Cesar Izaguirre + 3 more
The teaching-learning process in traditional university education uses strategies that position the student as a recipient of information conveyed by the teacher and conceptualized as knowledge. The reality in which we live, including the characteristics of new generational groups, requires the generation of training…