21 papers · ranked by Valyu relevance
Duan Zhou
This work simulates the developmental process of cortical neurogenesis, initiating from a single stem cell and governed by gene regulatory rules derived from mouse single-cell transcriptomic data. The developmental process spontaneously generates a heterogeneous population of 5,000 cells, yet yields only 85 mature…
Seema Islam, Ashaduzzaman Rubel Mondol, Aishwarya Pothula, Deokgun Park
'Deokgun Park'] As the current trend of artificial intelligence is shifting towards self-supervised learning, conventional norms such as highly curated domainspecific data, application-specific learning models, extrinsic reward based learning policies etc. might not provide with the suitable ground for such…
Antoni Matyjaszkiewicz, James Sharpe
Successful computational modelling of complex biological phenomena will depend on the seamless sharing of models and hypotheses between researchers of all backgrounds-experimental and theoretical. LimbNET, a new online tool for modelling, simulating and visualising spatiotemporal patterning in limb development, aims to…
Bradly Alicea, Rishabh Chakrabarty, Akshara Gopi, Anson Lim + 1 more
'Jesse Parent'] There is much to learn through synthesis of Developmental Biology, Cognitive Science and Computational Modeling. One lesson we can learn from this perspective is that the initialization of intelligent programs cannot solely rely on manipulation of numerous parameters. Our path forward is to present a…
Aishwarya Pothula, Md Ashaduzzaman Rubel Mondol, Sanath Narasimhan, SM Mazharul Islam + 1 more
'SM Mazharul Islam' 'Deokgun Park'] Abstract—Even with impressive advances in application specific models, we still lack knowledge about how to build a model that can learn in a human-like way and do multiple tasks. To learn in a human-like way, we need to provide a diverse experience that is comparable to human's. In…
Dali Wang, Zi Wang, Xiaopeng Zhao, Yichi Xu + 1 more
Recent developments in cutting-edge live microscopy and image analysis provide a unique opportunity to systematically investigate individual cell’s dynamics as well as simulation-based hypothesis testing. After a summary of data generation and analysis in the observation and modeling efforts related to C. elegans…
Lukas Breitwieser, Ahmad Hesam, Jean de Montigny, Vasileios Vavourakis + 9 more
Computer simulation is an indispensable tool for studying complex biological systems. In particular, agent-based modeling is an attractive method to describe biophysical dynamics. However, two barriers limit faster progress. First, simulators do not always take full advantage of parallel and heterogeneous hardware.…
Takahiro Kohsokabe, Shigeru Kuratanai, Kunihiko Kaneko
Determining the general laws between evolution and development is a fundamental biological challenge. Developmental hourglasses have attracted increased attention as candidates for such laws, but the necessity of their emergence remains elusive. We conducted evolutionary simulations of developmental processes to…
Roberta Bardini, Alfredo Benso, Gianfranco Politano, Stefano Di Carlo
Ontogenesis is the development of an organism from its earliest stage to maturity, including homeostasis maintenance throughout adulthood despite environmental perturbations. Almost all cells of a multicellular organism share the same genomic information. Nevertheless, phenotypic diversity and complex supra-cellular…
Xiangyu Kuang, Guoye Guan, Ming-Kin Wong, Lu-Yan Chan + 3 more
Morphogenesis is a precise and robust dynamic process during metazoan embryogenesis, consisting of both cell proliferation and cell migration. Despite the fact that much is known about specific regulations at the molecular level, how cell proliferation and migration together drive the morphogenesis at the cellular and…
Paddy Ross, Anthony P. Atkinson
Recent models of emotion recognition suggest that when people perceive an emotional expression, they partially activate the respective emotion in themselves, providing a basis for the recognition of that emotion. Much of the focus of these models and of their evidential basis has been on sensorimotor simulation as a…
S Ben Tahar, E Comellas, TJ Duerr, D Bakr + 3 more
The vertebrate limb provides a powerful system to study how growth and molecular signaling interact to shape complex skeletal patterns. However, how these processes are coordinated across space and time is not fully understood. This study introduces a computational tool to examine how growth interacts with positional…
Leo Pio-Lopez, Johanna Bischof, Jennifer V. LaPalme, Michael Levin
All cognitive agents are composite beings. Specifically, complex living agents consist of cells, which are themselves competent sub-agents navigating physiological and metabolic spaces. Behavior science, evolutionary developmental biology, and the field of machine intelligence all seek an answer to the scaling of…
Fady Girgis, Darrin J. Lee, Amir Goodarzi, Jochen Ditterich
Piaget's genetic epistemology has provided the constructivist approach upon which child developmental theories were founded, in that infants are thought to progress through distinct cognitive stages until they reach maturity in their early 20's. However, it is now well established that cognition continues to develop…
Oriol Canela-Xandri, Samira Anbari, Javier Buceta
This document is an extended version of the main text where some details and results are fleshed out. Further details can be also found in the manual of the code and at TiFoSi’s website: http://tifosi.thesimbiosys.com. Emerging phenomena in developmental biology and tissue engineering are the result of feedbacks…
Xiao Xiao, Hayoun Noh, Mar Gonzalez-Franco
Conversational AI is increasingly personalized around users' preferences, histories, goals, and knowledge, but much less around how users interpret and take up model outputs to construct and understand their reality. We draw on Robert Kegan's constructive-developmental theory as a complementary lens on this dimension.…
Gunther Eysenbach, Sarah Jung, Zonglin He, Fernando Alvarez-Lopez + 2 more
Background Simulation in virtual environments has become a new paradigm for surgeon training in minimally invasive surgery (MIS). However, this technology is expensive and difficult to access. Objective This study aims first to describe the development of a new gesture-based simulator for learning skills in MIS and…
Authors not listed
Self-organizing tissues, such as organoids, offer transformative potential beyond healthcare by enabling the sustainable production of advanced materials. Resource scarcity and global warming drive the need for innovative fabrication solutions. This prospective review explores developmental biology as a manufacturing…
Rita Kukafka, Polona Caserman, Taro Ueno, Ho Heon Kim + 2 more
Background Early detection of developmental disabilities in children is essential because early intervention can improve the prognosis of children. Meanwhile, a growing body of evidence has indicated a relationship between developmental disability and motor skill, and thus, motor skill is considered in the early…
Authors not listed
Electrochemiluminescence (ECL) is a vital analytical technique widely used in immunosensing and emerging applica-tions in biological imaging. Traditional ECL simulations rely on finite element methods, which provide valuable insights into reaction dynamics and spatial distribution of species. However, such methods are…
Alan Aspuru-Guzik, Roland Lindh, Markus Reiher
To date, the program for the development of methods and models for atomistic and continuum simulation directed toward chemicals and materials has reached an incredible degree of sophistication and maturity. Currently, one can witness an increasingly rapid emergence of advances in computing, artificial intelligence, and…