22 papers · ranked by Valyu relevance
Denis Le Bihan, Mami Iima
Since its introduction in the mid-1980s, diffusion magnetic resonance imaging (MRI), which measures the random motion of water molecules in tissues, revealing their microarchitecture, has become a pillar of modern neuroimaging. Its main clinical domain has been the diagnosis of acute brain stroke and neurogical…
Matteo Bastiani, Alard Roebroeck
The structural architecture and the anatomical connectivity of the human brain show different organizational principles at distinct spatial scales. Histological staining and light microscopy techniques have been widely used in classical neuroanatomical studies to unravel brain organization. Using such techniques is a…
Lydiane Hirschler, Nico Sollmann, Bárbara Schmitz‐Abecassis, Joana Pinto + 37 more
'Joana Pinto' 'Fatemehsadat Arzanforoosh' 'Frederik Barkhof' 'Thomas Booth' 'Marta Calvo‐Imirizaldu' 'Guilherme Cassia' 'Marek Chmelik' 'Patricia Clement' 'Ece Ercan' 'Maria A. Fernández‐Seara' 'Julia Furtner' 'Elies Fuster‐Garcia' 'Matthew Grech‐Sollars' 'Nazmiye Tugay Guven' 'Gokce Hale Hatay' 'Golestan Karami' 'Vera…
J. Matthew Debnam, Dawid Schellingerhout
Over the last several years, there has been significant advancement in the molecular characterization of intracranial diseases, particularly cerebral neoplasms. While nuclear medicine technology, including PET/CT, has been at the foreground of exploration, new MR imaging techniques, specifically diffusion-weighted and…
Santiago Aja-Fernández, Rodrigo de Luis-García, Maryam Afzali, Malwina Molendowska + 2 more
In diffusion MRI, the Ensemble Average diffusion Propagator (EAP) provides relevant microstructural information and meaningful descriptive maps of the white matter previously obscured by traditional techniques like the Diffusion Tensor. The direct estimation of the EAP, however, requires a dense sampling of the…
Pamela Wochner, Torben Schneider, Jason Stockmann, Jack Lee + 2 more
'Ralph Sinkus' 'Pew-Thian Yap'] Diffusion MRI classically uses gradient fields that vary linearly in space to encode the diffusion of water molecules in the signal magnitude by tempering its intensity. In spin ensembles, a presumably equal number of particles move in positive and negative direction, resulting in…
Rafael Neto Henriques, Marta Correa, Maurizio Maralle, Elizabeth Huber + 5 more
Diffusion-weighted magnetic resonance imaging (dMRI) measurements and models provide information about brain connectivity and are sensitive to the physical properties of tissue microstructure. Diffusional Kurtosis Imaging (DKI) quantifies the degree of non-Gaussian diffusion in biological tissue from dMRI. These…
Alexandru V. Avram, Kadharbatcha S. Saleem, Peter J. Basser
Diffusion MRI studies with resolutions of a few hundred micrometers have consistently shown that in the cortex water diffusion occurs preferentially along radial and tangential orientations with respect to the cortical surface, in agreement with histology. These dominant orientations do not change significantly even if…
Jessica T.E. Johnson, M. Okan Irfanoglu, Eppu Manninen, Thomas J. Ross + 5 more
Diffusion MRI with free gradient waveforms, combined with simultaneous relaxation encoding, referred to as multidimensional MRI (MD-MRI), offers microstructural specificity in complex biological tissue. This approach delivers intravoxel information about the microstructure, local chemical composition, and importantly…
F.J. Fritz, B.A. Poser, A. Roebroeck
There is an increasing interest in quantitative imaging of T_1_, T_2_ and diffusion contrast in the brain due to greater robustness against bias fields and artifacts, as well as better biophysical interpretability in terms of microstructure. However, acquisition time constraints are a challenge, particularly when…
Ileana Jelescu, Francesco Grussu, Andrada Ianuş, Brian Benjamin Hansen + 53 more
'Brian Benjamin Hansen' 'Rachel Barrett' 'Manisha Aggarwal' 'Stijn Michielse' 'Fatima A. Nasrallah' 'Warda Syeda' 'Nian Wang' 'Jelle Veraart' 'Alard Roebroeck' 'Andrew F. Bagdasarian' 'Cornelius Eichner' 'Farshid Sepehrband' 'Jan Zimmermann' 'Lucas Soustelle' 'Christien Bowman' 'Benjamin C. Tendler' 'Andreea Hertanu'…
Zezhong Ye, Sam E. Gary, Peng Sun, Sourajit Mitra Mustafi + 9 more
Diffusion tensor imaging (DTI) has been employed for over two decades to noninvasively quantify central nervous system (CNS) diseases/injuries. However, DTI is an inadequate simplification of diffusion modeling in the presence of co-existing inflammation, edema, and crossing nerve fibers. We employed a tissue phantom…
Marc Azagra, David Gomez-Cabeza, Alejandro Portela, Gergo Matajsz + 3 more
To foster the efficient development of 3D cell culture models, we developed a strategy to assess the liquid flow perfusion through biocompatible scaffolds. Biocompatible scaffolds play a crucial role in creating 3D in vitro models for precision medicine. Therefore, it is imperative to thoroughly characterise the…
Markus Nilsson, Filip Szczepankiewicz, Jan Brabec, Marie E. Taylor + 4 more
'Carl‐Fredrik Westin' 'Alexandra J. Golby' 'Danielle van Westen' 'Pia C. Sundgren'] Results: The fast imaging protocol yielded parameters with characteristics in terms of bias and precision similar to the full protocol. Glioblastomas had lower microscopic anisotropy than meningiomas (MKA = 0.29±0.06 versus 0.45±0.08, p…
Daniel C. Alexander, Tim B. Dyrby
Purpose: Stimulated echo acquisition mode (STEAM) diffusion MRI can be advantageous over pulsed-gradient spin-echo (PGSE) for diffusion times that are long compared to T2. It is important therefore for biomedical diffusion imaging applications at 7T and above where T2 is short. However, various gradient pulses in the…
Magdalena Stachera, D. Kotlorz, Katarzyna Sznajder
ABBREVIATIONS: ADC, apparent diffusion coefficient; Ala, alanine; Cho, choline; CNS, central nervous system; Cr, creatine; CSF, cerebrospinal fluid; CSI, chemical shift imaging; DW MRI, Diffusion-weighted magnetic resonance imaging; GBM, glioblastoma multiforme; GM, grey matter; HGG, high-grade gliomas; Ins…
Kanza Awais, Žiga Snoj, Erika Cvetko, Igor Serša + 3 more
'Federico Bruno' 'Ayesha Jameel'] The magnetic resonance Diffusion Tensor Imaging (DTI) is a powerful extension of Diffusion Weighted Imaging (DWI) utilizing multiple bipolar gradients, allowing for the evaluation of the microstructural environment of the highly anisotropic tissues. DTI was predominantly used for the…
Haykel Snoussi, Benoît Combès, Olivier Commowick, Élise Bannier + 4 more
'Anne Kerbrat' 'Julien Cohen‐Adad' 'Christian Barillot' 'Emmanuel Caruyer'] Abstract. In Multiple Sclerosis (MS), there is a large discrepancy between the clinical observations and how the pathology is exhibited on brain images, this is known as the clinical-radiological paradox (CRP). One of the hypotheses is that the…
Merry Mani, Mathews Jacob, Douglas A.C. Kelley, Vincent A. Magnotta
Methods: Current EPI-based MS-DW reconstruction methods rely on the explicit estimation of the motioninduced phase maps to recover the unaliased images. In the new formulation, the k-space data of the unaliased DWI is recovered using a structured low-rank matrix completion scheme, which does not require explicit…
Austin-John Fordham, Caitlin-Craft Hacherl, Neal Patel, Keri Jones + 4 more
'Brandon Myers' 'Mickey Abraham' 'Julian Gendreau' 'Jorn Fierstra'] Simple Summary The process of differentiating glioblastomas from solitary brain metastases is often difficult using traditional magnetic resonance imaging alone. In the past two decades, much progress has been made in devising advanced imaging…
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When producing plant-protein-based meat analogues via high moisture extrusion (HME), the structure of extrudates is determined by complex interactions between ingredient composition and processing conditions. To facilitate consumers in their transition towards a diet higher in plant-based proteins, the food industry…
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Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and widespread neurovascular disturbances. Traditional fMRI provides valuable spatial maps of blood-oxygen-level-dependent (BOLD) changes but often lacks the capacity to quantify the interplay of cerebral blood flow…