23 papers · ranked by Valyu relevance
M. Pekker, M.N. Shneider
A theoretical model of electrical synapses is proposed, in which connexons play the role of “nails” that hold unmyelinated areas of neurons at a distance of about 3.5 nm, and the electrical connection between them is provided by charging the membrane of an inactive neuron with currents generated in the intercellular…
E. Anne Martin, Abagael M. Lasseigne, Adam C. Miller
In this review article, we will describe the recent advances made towards understanding the molecular and cell biological mechanisms of electrical synapse formation. New evidence indicates that electrical synapses, which are gap junctions between neurons, can have complex molecular compositions including protein…
Tuan Pham, Julie S. Haas
As information about the world traverses the brain, the signals exchanged between neurons are passed and modulated by synapses, or specialized contacts between neurons. While neurotransmitter-based synapses tend to be either relay excitatory or inhibitory pulses of influence on the postsynaptic neuron, electrical…
Pau, L-F
As a step in the architectural design of a quantum processing or sensing system with control and signaling, an attempt is made at putting in parallel functional properties of the random flows between neurons through electrical synapses, and quantum particle flows inside a quantum processing system mimicking biological…
Sandra P Cárdenas-García, Sundas Ijaz, Alberto E Pereda, Vatsala Thirumalai + 1 more
'Vatsala Thirumalai' 'Sacha B Nelson'] Most nervous systems combine both transmitter-mediated and direct cell-cell communication, known as ‘chemical’ and ‘electrical’ synapses, respectively. Chemical synapses can be identified by their multiple structural components. Electrical synapses are, on the other hand…
Sandra P. Cárdenas-García, Sundas Ijaz, Alberto E. Pereda
Most nervous systems combine both transmitter-mediated and direct cell-cell communication, known as ‘chemical’ and ‘electrical’ synapses, respectively. Chemical synapses can be identified by their multiple structural components. Electrical synapses are, on the other hand, generally defined by the presence of a ‘gap…
Lei Xiao, Dan-ke Zhang, Yuan-qing Li, Pei-ji Liang + 1 more
The present study investigates a potential computational role of dynamical electrical synapses in neural information process. Compared with chemical synapses, electrical synapses are more efficient in modulating the concerted activity of neurons. Based on the experimental data, we propose a phenomenological model for…
Mitchell J. Vaughn, David S. Uygun, Radhika Basheer, Kevin J. Bender + 1 more
Electrical synapses are expressed ubiquitously across the brain and are crucial components of active neural circuitry and connectomes. Identification of coupled networks in living tissue is limited by technical demands of multiplexed recordings, and no dyes, fluorescent reporters, or genetic labels can currently fill…
Mitchell J. Vaughn, Kevin J. Bender, Julie S. Haas
Electrical synapses are present widely across the mammalian brain and are crucial components of active neural circuitry and connectomes. Identification of electrically coupled networks in living tissue has been limited by technical demands of multiplexed recordings, and no dyes, fluorescent reporters, or genetic labels…
Mitchell J. Vaughn, Julie S. Haas
Electrical synapses are the neurophysiological product of gap junctional pores between neurons that allow bidirectional flow of current between neurons. They are expressed throughout the mammalian nervous system, including cortex, hippocampus, thalamus, retina, cerebellum, and inferior olive. Classically, the function…
Gabrielle J Gutierrez, Eve Marder
Electrical synapses are known to promote synchrony and speed in neuronal systems. However, other studies have found that electrical synapses can have the opposite effect by desynchronizing network neurons. Although they are mechanistically simple, electrical synapses can have unintuitive effects on neuronal network…
Austin J. Mendoza, Julie S. Haas
Electrical synapses couple inhibitory neurons across the brain, underlying a variety of functions that are modifiable by activity. Despite recent advances, many functions and contributions of electrical synapses within neural circuitry remain underappreciated. Among these are the sources and impacts of electrical…
Lei Wang, Shu-Ren Lu, Jing Wen
Realization of brain-like computer has always been human’s ultimate dream. Today, the possibility of having this dream come true has been significantly boosted due to the advent of several emerging non-volatile memory devices. Within these innovative technologies, phase-change memory device has been commonly regarded…
Padinhare Cholakkal Harikesh, Chi‐Yuan Yang, Deyu Tu, Jennifer Y. Gerasimov + 9 more
Future brain-machine interfaces, prosthetics, and intelligent soft robotics will require integrating artificial neuromorphic devices with biological systems. Due to their poor biocompatibility, circuit complexity, low energy efficiency, and operating principles fundamentally different from the ion signal modulation of…
Jiawei Zhang
As a follow-up tutorial article of [29], in this paper, we will introduce the basic compositional units of the human brain, which will further illustrate the cell-level bio-structure of the brain. On average, the human brain contains about 100 billion neurons and many more neuroglia which serve to support and protect…
Mohammad Javad Hosseini, Elisa Donati, Giacomo Indiveri, Robert A. Nawrocki
'Robert A. Nawrocki'] Synapses play a critical role in memory, learning, and cognition. Their main functions include converting pre-synaptic voltage spikes to post-synaptic currents, as well as scaling the input signal. Several brain-inspired architectures have been proposed to emulate the behavior of biological…
Alexandra Pinto Castellanos
Neurons have the capability of transforming information from a digital signal at the dendrites of the presynaptic terminal to an analogous wave at the synaptic cleft and back to a digital pulse when they achieve the required voltage for the generation of an action potential at the postsynaptic neuron. The main question…
Thomas Heimburg
and consequences for the brain Authors: ['Thomas Heimburg'] ABSTRACT The action potential is widely considered a purely electrical phenomenon. However, one also finds mechanical and thermal changes that can be observed experimentally. In particular, nerve membranes become thicker and axons contract. The spatial length…
Kesheng Xu, Jean Paul Maidana, Patricio Orio
Many experiments have evidenced that electrical and chemical synapses – hybrid synapses – coexist in most organisms and brain structures. The role of electrical and chemical synapse connection in diversity of neural activity generation has been investigated separately in networks of varying complexities. Nevertheless…
Richa Sirmaur, Rishikesh Narayanan
Local field potentials (LFPs) are compound signals that represent the dynamic flow of information across the brain, which have been historically associated with chemical synaptic inputs. How do gap junctional inputs onto active compartments shape LFPs? We developed methodology to record extracellular potentials…
Authors not listed
Researching the EEEV virus is challenging due to the virus's high lethality and significant risk. This study employed bioinformatics methods for domain search to investigate the pathogenesis and infection process of the EEEV virus P protein. The results demonstrated that the EEEV virus P protein contains domains that…
Authors not listed
Acetylcholine (ACh) is a key neurotransmitter involved in cognitive function, motor control, and synaptic modulation, yet its electrochemical inactivity and the rapid kinetics of exocytosis have hindered real-time quantal detection. Previous micrometer-scale enzymatic ACh biosensors enabled sub-millisecond…
Afsaneh Taheri Kal-Koshvandi
We present the first light-free, genetically minimal platform for spatiotemporally resolved proximity labeling across five neuronal compartments—synaptic, nuclear, endosomal, mitochondrial, and activity-dependent microdomains. A covalent "catalyst–luciferase sandwich" architecture site-specifically conjugates five…