24 papers · ranked by Valyu relevance
Riya R. Kanherkar, Naina Bhatia-Dey, Antonei B. Csoka
Epigenetics has the potential to explain various biological phenomena that have heretofore defied complete explication. This review describes the various types of endogenous human developmental milestones such as birth, puberty, and menopause, as well as the diverse exogenous environmental factors that influence human…
Azam Moosavi, Ali Motevalizadeh Ardekani
For a long time, scientists have tried to describe disorders just by genetic or environmental factors. However, the role of epigenetics in human diseases has been considered from a half of century ago. In the last decade, this subject has attracted many interests, especially in complicated disorders such as behavior…
Victoria K. Cortessis, Duncan C. Thomas, A. Joan Levine, Carrie V. Breton + 4 more
'Carrie V. Breton' 'Thomas M. Mack' 'Kimberly D. Siegmund' 'Robert W. Haile' 'Peter W. Laird'] Changes in epigenetic marks such as DNA methylation and histone acetylation are associated with a broad range of disease traits, including cancer, asthma, metabolic disorders, and various reproductive conditions. It seems…
Delphine Fradin, Pierre Bougnères
Type 2 Diabetes Mellitus (T2DM) is a metabolic disorder influenced by interactions between genetic and environmental factors. Epigenetics conveys specific environmental influences into phenotypic traits through a variety of mechanisms that are often installed in early life, then persist in differentiated tissues with…
Mauro Mandrioli, Jürg Bähler, Michael Hackenberg
In the last decade, it has been suggested that epigenetics may enhance the adaptive possibilities of animals and plants to novel environments and/or habitats and that such epigenetic changes may be inherited from parents to offspring, favoring their adaptation. As a consequence, several Authors called for a shift in…
Amy K. Webster, Patrick C. Phillips
Understanding how genetic and phenotypic variation is maintained is a major problem in population and quantitative genetics. A variety of factors have been implicated to explain the maintenance of genetic variation in some contexts (e.g. balancing selection), but the potential role of epigenetic regulation to influence…
Marco Miceli
The term “epigenetics” comes from the union of the words “epigenesis” and “genetics”, coined by the British embryologist Conrad Waddington in 1942 [1], to contrast the preformationist theory, prevalent at that time, according to which adult organisms are already preformed in miniature (germini) in the egg or in the…
Ute Deichmann
Epigenetics researchers in developmental, cell, and molecular biology greatly diverge in their understanding and definitions of epigenetics. In contrast, social epigeneticists, e.g., sociologists, scholars of STS, and behavioural scientists, share a focus and definition of epigenetics that is environmentally caused and…
Lifeth Alvarez Camacho
Many biological processes have been the source of inspiration for heuristic methods that generate high-quality solutions to solve optimization and search problems. This thesis presents an epigenetic technique for Evolutionary Algorithms, inspired by the epigenetic regulation process, a mechanism to better understand…
Angela Oliveira Pisco, Aymeric Fouquier d’Hérouël, Sui Huang
The observations of phenotypic plasticity have stimulated the revival of ‘epigenetics’. Over the past 70 years the term has come in many colors and flavors, depending on the biological discipline and time period. The meanings span from Waddington’s “epigenotype” and “epigenetic landscape” to the molecular biologists’…
Norberto Sánchez-Cruz, Jose L. Medina-Franco
Epigenetic targets are a significant focus for drug discovery research, as demonstrated by the eight approved epigenetic drugs for treatment of cancer and the increasing availability of chemogenomic data related to epigenetics. This data represents a large amount of structure-activity relationships that has not been…
Valentina Carlini, Cristina Policarpi, Jamie A. Hackett
Environmental factors can trigger cellular responses that propagate across mitosis or even generations. Perturbations to the epigenome could underpin such acquired changes, however, the extent and contexts in which modified chromatin states confer heritable memory in mammals is unclear. Here we exploit a modular…
Mohamed Djallel Dilmi, Hanene Azzag, Mustapha Lebbah
Genetic algorithms are a well-known example of bio-inspired heuristic methods. They mimic natural selection by modeling several operators such as mutation, crossover, and selection. Recent discoveries about Epigenetics regulation processes that occur "on top of" or "in addition to" the genetic basis for inheritance…
K. Eurídice Juárez-Mercado, Juan F. Avellaneda-Tamayo, Hassan Villegas-Quintero, Ana L. Chávez-Hernández + 2 more
There is increasing awareness of epigenetics's importance in understanding disease etiologies and developing novel therapeutics. An increasing number of publications in the past few years reflect the renewed interest in epigenetic processes and their relationship with food chemicals. However, there needs to be a recent…
Evelyne Saade, Vasily Ogryzko
Epigenetics has captured the attention of scientists in the past decades, yet its scope has been continuously changing. In this paper, we give an overview on how and why its definition has evolved and suggest several clarification on the concepts used in this field. Waddington coined the term in 1942 to describe genes…
R Mashoodh, P Sarkies, J Westoby, RM Kilner
Levels of parental care critically influence the developmental environment with the capacity to impact the growth, survival, physiology, and behaviour of offspring. Plastic changes in DNA methylation have been hypothesised to modulate gene expression responses to parental environments. Moreover, these effects can be…
Tania Chavarria-Pizarro, Mohammed Errbii, Benne Köster, Mjtia Möhleke + 2 more
Epigenetic mechanisms are increasingly recognized as key drivers of phenotypic plasticity in social insects, where the caste and function of an individual is usually not determined by its genotype. These mechanisms may also regulate variation in social behavior or interactions and ultimately social organization. We…
Floriane Nicol‐Benoit, Pascale Le Goff, Denis Michel
Epigenetics is most often reduced to chromatin marking in the current literature, whereas this notion was initially defined in a more general context. This restricted view ignores that epigenetic memories are in fact more robustly ensured in living systems by steady state mechanisms with permanent molecule renewal.…
Ken Nishikawa, Akira R. Kinjo
The Weismann barrier, or the impossibility of inheritance of acquired traits, comprises a foundation of modern biology, and it has been a major obstacle in establishing the connection between evolution and ontogenesis. We propose the cooperative model based on the assumption that evolution is achieved by a cooperation…
Norberto Sánchez-Cruz, Jose L. Medina-Franco
Motivation: The identification of protein targets of small molecules is essential for drug discovery. With the increasing amount of chemogenomic data in the public domain, multiple ligand-based models for target prediction have emerged. However, these models are generally biased by the number of known ligands for…
Daniel Stopper, Susanna Buntrock, Kathrin Tan, Lais Pessanha de Carvalho + 4 more
Epigenetic drug targets have become an important focus in drug discovery. One of the key mechanisms in epigenetics is the acetylation and deacetylation of histone proteins. In this study, we synthesized and evaluated novel histone deacetylase (HDAC) inhibitors derived from the clinical candidate quisinostat. A library…
Authors not listed
Histone deacetylases (HDACs) are promising targets for epigenetic drug discovery. Additionally, targeted degradation of HDACs has emerged as a novel approach in medicinal chemistry and chemical biology. However, most inhibitors and degraders rely on the potentially genotoxic hydroxamate as a zinc-binding group (ZBG).…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in brain, along with neuroinflammation and synaptic dysfunction. Genetic…