24 papers · ranked by Valyu relevance
Haleema Anwar, Qudsia Umaira Khan, Natasha Nadeem, Iqra Pervaiz + 2 more
'Muhammad Ali' 'Fatima Fayyaz Cheema'] Epilepsy is a condition marked by abnormal neuronal discharges or hyperexcitability of neurons with synchronicity and is recognized as a major public health concern. The pathology is categorized into three subgroups: acquired, idiopathic, and epilepsy of genetic or developmental…
Alexander Muacevic, John R Adler, Abdullah Ahmed, Abdul-Habib Rahman + 6 more
'Shimul Williams' 'Mubeen Toufiq' 'Eyad Jamileh' 'Sheema Chaudhry' 'Khadijah Ahmed' 'Munir Ahmed'] Epilepsy is a common neurological disorder impacting millions globally, marked by recurrent, unprovoked seizures. This review article, tailored for UK medical students, provides a broad clinical overview of epilepsy…
Puja Patel, Solomon L. Moshé
This review aims to highlight the historical hallmarks in the development of the concepts of seizures and epilepsy. It begins with a discussion of seizure semiology and terminology, followed by the pathophysiology of seizures. We then discuss the definition of epilepsy, its etiologies, and ultimately classification…
Alexander Muacevic, John R Adler, Pranvera Hoxhaj, Sana K Habiya + 10 more
'Rithika Sayabugari' 'Roghan Balaji' 'Roshni Xavier' 'Arghal Ahmad' 'Mousumi Khanam' 'Meet Popatbhai Kachhadia' 'Tirath Patel' 'Zain U Abdin' 'Ali Haider' 'Zahra Nazir'] It has been noted that people who have epilepsy have an increased propensity for cognitive dysfunction. We explored 25 relevant articles on PubMed and…
Abbas Tafakhori, Vajiheh Aghamollaii, Sara Faghihi-Kashani, Payam Sarraf + 1 more
'Payam Sarraf' 'Laleh Habibi'] Epilepsy is one of the most common neurological disorders. Studies have demonstrated that genetic factors have a strong role in etiology of epilepsy. Mutations in genes encoding ion channels, neurotransmitters and other proteins involved in the neuronal biology have been recognized in…
Jaya Kumar, Amro Solaiman, Pasuk Mahakkanukrauh, Rashidi Mohamed + 1 more
'Srijit Das'] In the last several decades, sleep-related epilepsy has drawn considerable attention among epileptologists and neuroscientists in the interest of new paradigms of the disease etiology, pathogenesis and management. Sleep-related epilepsy is nocturnal seizures that manifest solely during the sleep state.…
José Luis Hernández-Cáceres, Liudmila Lukianenko, Elena Venskaya, Yury D. Nechipurenko + 3 more
Epilepsy affects more than 52 million people worldwide and has been known since ancient times. Despite this long history, available therapeutic methods—both pharmacological and non-pharmacological—fail to control seizures in over 10% of patients. At the same time, there exists a diversity of theories regarding the…
Maria Luisa Saggio, Dakota Crisp, Jared Scott, Phillippa J. Karoly + 12 more
Seizures are a disruption of normal brain activity present across a vast range of species, diseases, and conditions. Here we introduce an organizing principle that leads to the first objective Taxonomy of Seizure Dynamics (TSD) based on bifurcation theory, and applied it to the analysis of EEG data. The “dynamotype” of…
Fatma El Abed, Ghada Baraket, Marion N. Nyamari, Careen Naitore + 1 more
Epilepsy is a neurological disease defined by episodes of synchronous convulsions. Recently, miRNAs have been proven as promising biomarkers for multiple ailments like tumors and neurodegenerative disorders; their role in epilepsy is still unclear. This study aimed to understand the involvement of miRNAs in the disease…
Aravind Kumar Kamaraj, Matthew Parker Szuromi, Daniel Galvis, William Stacey + 2 more
Epileptic seizures are characterized by abnormal synchronous bursting of neurons. This is commonly attributed to an imbalance between excitatory and inhibitory neurotransmission. We introduce compartmental models from epidemiology to study this interaction between excitatory and inhibitory populations of neurons in the…
Sekhar Talluri
Epilepsy is a common disorder of the Central Nervous System. Although several drugs are available for treatment of epilepsy, none of them are applicable for all cases, and some have serious adverse affects. The rational design of small molecule drugs for disorders of the Central Nervous System is a difficult process…
S. Martín-Suárez, JM Cortes, P. Bonifazi
Epilepsy, the condition of recurrent unprovoked seizures resulting from a wide variety of causes, is one of the world’s most prominent brain syndrome. Seizures which are an expression of neuronal network dysfunction occur in a positive feedback loop of concomitant factors where seizures generate more seizures…
Rafael Chitolina, Matheus Gallas-Lopes, Carlos G. Reis, Radharani Benvenutti + 4 more
The use of zebrafish as a model organism is gaining evidence in the field of epilepsy as it may help to understand the mechanisms underlying epileptic seizures. As zebrafish assays became popular, the heterogeneity between protocols increased, making it hard to choose a standard protocol to conduct research while also…
Neha Choudhary, Vikram Singh
Epilepsy comprises a wide spectrum of neuronal disorders and accounts for about one percent of global disease burden affecting people of all age groups. In the traditional medicinal system of Indian antiquity, commonly known as Ayurveda, epilepsy is recognised as apasmara and a plenty of information is documented…
Maria Luisa Saggio, Viktor Jirsa
In this chapter we review phenomenological models of seizure like activity. We discuss dynamical mechanisms for seizure onset and offset, preictal spikes, spike and wave complexes and status epilepticus, highlighting the role played by the bifurcation structure of the model, the presence of noise and the emergence of…
Atefeh Khoshkhahtinat, Hoda Mohammadzade
—Epilepsy is a neurological disorder identified by sudden and recurrent seizures, which are believed to be accompanied by distinct changes in brain dynamics. Exploring the dynamic changes of brain network states during seizures can pave the way for improving the diagnosis and treatment of patients with epilepsy. In…
Miguel Bhagubai, Christos Chatzichristos, Lauren Swinnen, Jaiver Macea + 9 more
'Jaiver Macea' 'Jingwei Zhang' 'Lieven Lagae' 'Katrien Jansen' 'Andreas Schulze‐Bonhage' 'Francisco Sales' 'Benno Mahler' 'Yvonne G. Weber' 'Wim Van Paesschen' 'Maarten De Vos'] The increasing technological advancements towards miniaturized physiological measuring devices have enabled continuous monitoring of epileptic…
Zag ElSayed, Murat Özer, Nelly Elsayed
—A seizure tracking system is crucial for monitoring and evaluating epilepsy treatments. Caretaker seizure diaries are used in epilepsy care today, but clinical seizure monitoring may miss seizures. Monitoring devices that can be worn may be better tolerated and more suitable for long-term ambulatory use. Many…
Zaghloul Saad Zaghloul, Magdy Bayoumi
—Controlling the surrounding world and predicting future events has always seemed like a dream, but that could become a reality using a Brain-Computer/Machine Interface (BCI/BMI). Epilepsy is a group of neurological diseases characterized by epileptic seizures. It affects millions of people worldwide, with 80% of cases…
Mekdes Tigistu, Telake Azale, Habtamu Kebebe, Temesgen Yihunie
Objective About three-fourth of adults with new-onset epilepsy become seizure-free with current anti-epileptic drugs, but around one-fourth of the patients continue to experience seizure which increases the risk of accident, disability, death and treatment side effects. Therefore, this study aimed to address the gap in…
Afshin Shoeibi, Navid Ghassemi, Marjane Khodatars, Mahboobeh Jafari + 8 more
and Prediction Based on Neuroimaging Modalities: Methods, Challenges, and Future Works Authors: ['Afshin Shoeibi' 'Navid Ghassemi' 'Marjane Khodatars' 'Mahboobeh Jafari' 'Parisa Moridian' 'Roohallah Alizadehsani' 'Yinan Kong' 'J. M. Górriz' 'Javier Ramı́rez' 'Abbas Khosravi' 'Saeid Nahavandi' 'U. Rajendra Acharya']…
Arsalan Heidarpanah
During the last three decades, many studies have been conducted in the field of treatment with non-invasive methods. In this way, researchers try to use alternative methods including the use of electromagnetic waves in the treatment of diseases. As a result, the therapeutic use of electromagnetic waves in the treatment…
Authors not listed
The GluK1 receptor, an ionotropic glutamate receptor, operates as a ligand-gated ion channel. Opioids stand as the most potent pain-relieving medications currently prescribed in the medical field. Inhibiting this receptor is anticipated to result in a reduction of dopamine release in the Nucleus Accumbens, effectively…
Authors not listed
Researching the EEEV virus is challenging due to the virus's high lethality and significant risk. This study employed bioinformatics methods for domain search to investigate the pathogenesis and infection process of the EEEV virus P protein. The results demonstrated that the EEEV virus P protein contains domains that…