26 papers · ranked by Valyu relevance
Nahuel Freitas, Karel Proesmans, Massimiliano Esposito
We find the relation between reliability and entropy production in a realistic model of electronic memory (low-power MOS-based SRAM) where logical values are encoded as metastable nonequilibrium states. We employ large deviations techniques to obtain an analytical expression for the bistable quasipotential describing…
Lindemberg Assunção-Costa, Ivellise Costa de Sousa, Renata Kelly Rodrigues Silva, Ana Carla do Vale + 4 more
'Renata Kelly Rodrigues Silva' 'Ana Carla do Vale' 'Charleston Ribeiro Pinto' 'Juliana Ferreira Fernandes Machado' 'Cleidenete Gomes Valli' 'Luis Eugenio Portela Fernandes de Souza'] Background Medication administration errors are frequent and cause significant harm globally. However, only a few data are available on…
Richard J. Wang, Predrag Radivojac, Matthew W. Hahn
Errors in genotype calling can have perverse effects on genetic analyses, confounding association studies and obscuring rare variants. Analyses now routinely incorporate error rates to control for spurious findings. However, reliable estimates of the error rate can be difficult to obtain because of their variance…
Weiyi Li, Stephan Baehr, Michelle Marasco, Lauren Reyes + 5 more
The expression of genomically-encoded information is not error-free. Transcript-error rates are dramatically higher than DNA-level mutation rates, and despite their transient nature, the steady-state load of such errors must impose some burden on cellular performance. However, a broad perspective on the degree to which…
Omer Markovitch, Juntian Wu, Otto Sijbren
Copying information is vital for life's propagation. Current life forms maintain a low error rate in replication using complex machinery to prevent and correct errors. However, primitive life had to deal with higher error rates, limiting its ability to evolve. Discovering mechanisms to reduce errors would alleviate…
H. Mertens, Marc Van Droogenbroeck
The Viterbi algorithm, presented in 1967, allows a maximum likelihood decoding of partial response codes. This study focuses on the duobinary code which is the first member of this family and has been specified for the digital part of television systems recommended by International Organizations. Up to now the…
Pengyao Ping, Shuquan Su, Xinhui Cai, Tian Lan + 5 more
Although the per-base erring rate of NGS is very low at 0.1% to 0.5%, the percentage/probability of erroneous reads in a short-read sequencing dataset can be as high as 10% to 15% or in the number of millions. Correction of these wrongly sequenced reads to retrieve their huge missing value will improve many downstream…
K.M. Meer, P.G. Nelson, K. Xiong, J. Masel
Errors in gene transcription can be costly, and organisms have evolved to prevent their occurrence or mitigate their costs. The simplest interpretation of the drift barrier hypothesis suggests that species with larger population sizes would have lower transcriptional error rates. However, Escherichia coli seems to have…
Premashis Kumar, Kinshuk Banerjee, G. Gangopadhyay
Kinetic proofreading mechanisms explain the extraordinary accuracy observed in central biological events in terms of the enhanced specificity of substrate selection networks under a nonequilibrium environment. The nonequilibrium steady state theory incorporated with a chemical thermodynamic framework is implemented to…
Jonas Poehls, Cedric Landerer, Katherine Daniels, Agnes Toth-Petroczy
Protein translation is an error-prone process resulting in a random population of altered protein sequences in every cell. Here, we analyzed thousands of publicly available mass spectrometry datasets to detect amino acid misincorporations and quantify error rates in 14 model organisms. We find that overall error rates…
Nobuaki Masaki, Sharon R. Browning, Brian L. Browning
Genotype data include errors that may influence conclusions reached by downstream statistical analyses. Previous studies have estimated genotype error rates from discrepancies in human pedigree data, such as Mendelian inconsistent genotypes or apparent phase violations. However, uncalled deletions, which generally have…
Yipeng Yin, Reed Arneson, Yinan Yuan, Shiyue Fang
The longest oligos that can be chemically synthesized using known methods are typically considered to be 200-mers. Here, we report direct synthesis of an 800-mer green fluorescent protein (GFP) gene and a 1,728-mer Φ29 DNA polymerase gene on an automated synthesizer. Key innovations that enabled the breakthrough…
Lucas B. Carey
Errors during transcription may play an important role in determining cellular phenotypes: the RNA polymerase error rate is >4 orders of magnitude higher than that of DNA polymerase and errors are amplified >1000-fold due to translation. However, current methods to measure RNA polymerase fidelity are low-throughout…
Hassan Bayat
Reliability of laboratory results is determined by the ratio of incorrect results expected in long-term. Sigma is a measure of defect ratio, therefore long-term Sigma is a measure of the reliability of laboratory results. Commonly, long-term Sigma is estimated based on the short-term Sigma. The Six Sigma methodology…
Davide Chiuchiú, Yuhai Tu, Simone Pigolotti
Synthesis of biopolymers such as DNA, RNA, and proteins are biophysical processes aided by enzymes. Performance of these enzymes is usually characterized in terms of their average error rate and speed. However, because of thermal fluctuations in these single-molecule processes, both error and speed are inherently…
Fatemeh Dabaghzadeh, Arash Rashidian, Hassan Torkamandi, Sara Alahyari + 3 more
'Sara Alahyari' 'Somayaeh Hanafi' 'Shadi Farsaei' 'Mohammadreza Javadi'] Medication errors have important effects on increased length of hospitalization, increased mortality and costs. We assessed the incidence of medication errors and characterize the error types in an emergency department in a large teaching hospital…
Felix Wong, Ariel Amir, Jeremy Gunawardena
Discriminating between correct and incorrect substrates is a core process in biology but how is energy apportioned between the conflicting demands of accuracy (µ), speed (σ) and total entropy production rate (P)? Previous studies have focussed on biochemical networks with simple structure or relied on simplifying…
William Daniels, Meng Jia, Dorit Hammerling
We propose a generic, modular framework for emission event detection, localization, and quantification on oil and gas production sites that uses concentration data collected by pointin-space continuous monitoring systems (CMS). The framework uses a gradient-based spike detection algorithm to estimate emission start and…
Authors not listed
Knowledge of the reaction rate constants can be vital in understanding electrochemical reaction mechanisms and their rate-determining processes. Although first-principles methods, such as density functional theory (DFT), provide valuable insight into reaction free energies and rate constants, they commonly use…
Nahoko Takada, Tipporn Laohakangvalvit, Midori Sugaya, María Dolores Martínez Aires + 2 more
'María Dolores Martínez Aires' 'Diego Pablo Ruiz Padillo' 'Juan Antonio Holgado-Terriza'] As human’s simple tasks are being increasingly replaced by autonomous systems and robots, it is likely that the responsibility of handling more complex tasks will be more often placed on human workers. Thus, situations in which…
Xiaoming Ye, Haibo Liu, Xuebin Xiao, Mo Ling
In several literatures, the authors give a new thinking of measurement theory system based on error non-classification philosophy, which completely overthrows the existing measurement concept system of precision, trueness and accuracy. In this paper, by focusing on the issues of error's regularities and effect…
William Daniels, Meng Jia, Dorit Hammerling
We propose a generic, modular framework for methane emission event detection, localization, and quantification on oil and gas production sites that uses concentration and wind data collected by point-in-space continuous monitoring systems. The framework uses a gradient-based spike detection algorithm to estimate…
Nicola Scafetta
Schmidt, Jones & Kennedy (SJK) (2023, https://doi.org/10.1029/2022GL102530, submited to GRL)'s critique of Scafetta (2022, https://doi.org/10.1029/2022GL097716) is flawed. Their assessment of the error of the ERA-T2m 2011–2021 mean (≈ 0.10 ◦C) is 5-10 times overestimated and contradicts published literature. SJK…
Authors not listed
Due to a production error, the equation for “Overall Accuracy” was typeset erroneously. The correct equation follows below: \text{Accuracy}=\text{ }\frac{\text{True Positives }+\text{ True Negatives}}{\text{True Positives }+\text{ True Negatives }+\text{ False Positives }+\text{ False Negatives}} The publisher…
Nancy C Elder, Harini Pallerla, Saundra Regan
Background Physicians are being asked to report errors from primary care, but little is known about how they apply the term "error." This study qualitatively assesses the relationship between the variety of error definitions found in the medical literature and physicians' assessments of whether an error occurred in a…
Alana C. Keegan, Sanuja Bose, Katherine M. McDermott, Midori P. Starks White + 8 more
In the published article, there was an error in [T2] as published. Some of the characteristics that represent means (standard deviation) are designated as representing (%). The corrected [T2] and its caption appear below. The authors apologize for this error and state that this does not change the scientific…