21 papers · ranked by Valyu relevance
Fanny Buckinx, Yves Rolland, Jean-Yves Reginster, Céline Ricour + 2 more
'Jean Petermans' 'Olivier Bruyère'] Frailty is a major health condition associated with ageing. Although the concept is almost universally accepted, its operational definition remains controversial. Anyway, this geriatric condition represents a huge potential public health issue at both the patient and the societal…
Alethea Lacas, Kenneth Rockwood
Frail, older patients pose a challenge to the primary care physician who may often feel overwhelmed by their complex presentation and tenuous health status. At the same time, family physicians are ideally suited to incorporate the concept of frailty into their practice. They have the propensity and skill set that lends…
Sara Rebottini, Pietro Belloni
Identifying frail older adults in an ageing population is essential for improving healthcare services. This study proposes a composite indicator to assess individual frailty levels using administrative healthcare data. Given the complex and multidimensional nature of frailty, a multi-outcome approach is adopted.…
Margherita Silan, Maurizio Nicolaio, Giovanna Boccuzzo
Frailty assessment is crucial for stratifying populations and addressing healthcare challenges associated with ageing. This study proposes a Frailty Index based on administrative health data, with the aim of facilitating informed decision-making and resource allocation in population health management. The aim of this…
Ivonne Hernandez Schulman, Wayne Balkan, Joshua M. Hare
Chronic diseases and degenerative conditions are strongly linked with the geriatric syndrome of frailty and account for a disproportionate percentage of the health care budget. Frailty increases the risk of falls, hospitalization, institutionalization, disability, and death. By definition, frailty syndrome is…
Nicole K. Bart, Alice Powell, Peter S. Macdonald
Frailty is a complex, multi-system condition often associated with multimorbidity. It has become an important prognostic maker across a range of conditions and is particularly relevant in patients with cardiovascular disease. Frailty encompasses a range of domains including, physical, psychological, and social. There…
Izabella Uchmanowicz, Jadwiga Nessler, Robbert Gobbens, Andrzej Gackowski + 4 more
'Andrzej Gackowski' 'Donata Kurpas' 'Ewa Straburzynska-Migaj' 'Marta Kałuzna-Oleksy' 'Ewa A. Jankowska'] People over 65 years of age constitute over 80% of patients with heart failure (HF) and the incidence of HF is 10 per 1,000 in people aged above 65 years. Approximately 25% of older patients with HF exhibit evidence…
Salvatore Sciacchitano, Valeria Carola, Giampaolo Nicolais, Simona Sciacchitano + 6 more
Many factors have contributed to rendering frailty an emerging, relevant, and very popular concept. First, many pandemics that have affected humanity in history, including COVID-19, most recently, have had more severe effects on frail people compared to non-frail ones. Second, the increase in human life expectancy…
Ahmed Ghachem, Linda P. Fried, Véronique Legault, Karen Bandeen-Roche + 2 more
Frailty is a clinical syndrome often present in older adults and characterized by a heightened vulnerability to stressors. The biological antecedents and etiology of frailty are unclear despite decades of research: frailty is associated with dysregulation in a wide range of physiological systems, but no specific cause…
Susan B. Gee, Gary Cheung, Ulrich Bergler, Hamish Jamieson
There is general agreement that frailty is common and important in later life, but there is less agreement about what frailty is. Little is known about the extent to which practicing health professionals and older people hold a mutual understanding of frailty. Focus groups were held to engage older people and health…
Yannick van Sleen, Sudarshan A Shetty, Marieke van der Heiden, Milou CA Venema + 6 more
Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score frailty, studies have employed the questionnaires, such as the SF-36 and EQ-5D-3L, or the Frailty Index, a composite score based on deficit accumulation. Furthermore, ageing of…
Dilara Yılmaz, Amit Singh, Esther Wehrle, Gisela A. Kuhn + 2 more
Frailty, a geriatric syndrome, is assessed using the frailty phenotype (FP) and frailty index (FI). While these approaches have been applied to aging mice, their effectiveness in prematurely aging mouse models such as PolgA^D257A/D257A^ (PolgA) has not been completely explored. We demonstrated that frailty became…
Vertica Agnihotri, Abhishek Gupta, Rashmita Pradhan, G Venugopalan + 3 more
Frail elderly is very common in Indian society and extremely difficult to manage in the clinical practice. Blood proteomic study may able to improve the specific diagnostic profiles and therapeutic templates for improving quality of life in elderly. The purpose of present study is to differentiate between frail and…
Glen Pridham, Kenneth Rockwood, Andrew D. Rutenberg
We predict the Fried physical frailty phenotype health deficits (FPFP5: slow gait, weakness, weight loss, low activity, and exhaustion) using two measures of frailty: frailty index (FI) or frailty phenotype (FP). The FP theorizes that the FPFP5 are mutually dependent through shared etiology and positive feedbacks, so…
Swadhin Taneja, Arnold Mitnitski, Kenneth Rockwood, Andrew D. Rutenberg
'Andrew D. Rutenberg'] How long people live depends on their health, and how it changes with age. Individual health can be tracked by the accumulation of age-related health deficits. The fraction of age-related deficits is a simple quantitative measure of human aging. This quantitative frailty index (F) is as good as…
Oliver G Frost, Anna Barkovskaya, Michael Rae, Abdelhadi Rebbaa + 1 more
Animal lifespan studies are foundational to developing interventions against the biological aging process. In recent years, there has been rising interest in characterizing the effects of longevity therapeutics on health span. Frailty indexes, originally developed to assess clinical frailty in aging humans, have shown…
Ghalib A. Bello, Yueh-Hsiu M. Chiu, Gerard G. Dumancas
To study the link between frailty and cellular senescence, we examine the association of leukocyte telomere length (LTL) with a recently introduced measure of subclinical frailty that is based entirely on laboratory test biomarkers (FI-LAB). This study was conducted on a random sample of 1890 Americans aged 60+.…
Aniol Civit, Antonio Andriella, Alba Martínez, Joan Ars + 3 more
Frailty assessments are crucial to evaluate the risk of adverse events and the health and social care needs of older adults, yet their administration remains resource-intensive and typically relies on coarse clinical outcomes, such as task completion times, which may overlook biomechanical indicators of functional…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, memory loss, and impaired daily functioning. The pathology of AD is marked by the accumulation of amyloid-beta plaques and tau protein tangles in brain, along with neuroinflammation and synaptic dysfunction. Genetic…
Authors not listed
A steep, age‑related drop in nicotinamide adenine dinucleotide (NAD+) now ranks among the most reproducible molecular signatures of human aging, driving metabolic slowdown, mitochondrial dysfunction, DNA‑repair deficits, chronic inflammation, and stem‑cell fatigue. Boost NAD+ for Anti‑Aging: A Multidimensional Review…