20 papers · ranked by Valyu relevance
Elad Yoshai, Gil Goldinger, Miki Haifler, Natan T. Shaked
permanent-section-guided deep learning with nuclei attention Authors: ['Elad Yoshai' 'Gil Goldinger' 'Miki Haifler' 'Natan T. Shaked'] - 1 School of Electrical and Computer Engineering, Tel Aviv University, Tel Aviv, Israel - 2 Chaim Sheba Medical Center, Ramat Gan, Israel - 3 Sackler Faculty of Medicine, Tel Aviv…
Atif Ali Hashmi, Samreen Naz, Muhammad Muzzammil Edhi, Naveen Faridi + 3 more
'Syed Danish Hussain' 'Shazia Mumtaz' 'Mehmood Khan'] Background Ovarian neoplasms are a heterogeneous group of tumors including surface epithelial, germ cell and sex cord stromal tumors with a subset having low malignant potential (borderline tumors). While the surgical management plan differs in different categories…
Amita Maheshwari, Sudeep Gupta, Shubhada Kane, Yogesh Kulkarni + 2 more
'Lt Col Bhupesh Kumar Goyal' 'Hemant B Tongaonkar'] Background Epithelial ovarian neoplasms are an important cause of morbidity and mortality in women. The surgical management of ovarian neoplasms depends on their correct categorization as benign, borderline or malignant. This study was undertaken to evaluate the…
Alexander Muacevic, John R Adler, Neelayadakshi B., Sudha V.
Introduction Uterine masses are commonly submitted for frozen section, to guide the surgeon, regarding the type and extent of the procedure during surgery. Despite the technical difficulties in processing, sectioning, and staining of frozen section samples, it remains a fairly reliable intraoperative tool. Aim This…
Marwan Odeh, Ayat Qasoum, Rene Tendler, Mohamad Kais + 2 more
'Rola Khamise Farah' 'Jacob Bornstein'] Objective Frozen section examination is a rapid method for identifying products of conception in endometrial curetting, yet its accuracy is inconclusive. The purposes of this study is to determine the accuracy of frozen section analysis of endometrial curetting in pregnancies of…
Benjamin Heller, Stephen Peters
Although frozen sections are a useful and accurate modality for the evaluation of tissue, there are known pitfalls. The ability to correctly interpret a frozen section will vary with the quality of the preparation. There can be considerable variation in the quality of frozen sections preparations depending on…
Fatima Taiki, Helmut Gnaegi, Mikhail Eltsov, Amélie Leforestier
Cellular cryo electron tomography explores tissue and cells in their unstained flash-frozen native state, revealing in situ the structure of macromolecules together with their local environment and interactions with partners, also known as molecular sociology. To obtain thin samples, cryo-FIB milling is nowadays the…
O. V. Ivakhnenko, O. F. Todrin, V.Yu. Globa, M.O. Chyzh + 2 more
Using thermal imaging for cryoablation and cryotherapy is a convenient technique but it does not allow for visualization of what is inside. We model thermal field distribution which can help relate surface thermal field images to in-depth temperature field dynamics that show freezing and thawing processes dynamics. We…
Leif-Thore Deck, David Richard Ochsenbein, Marco Mazzotti
Biopharmaceuticals commonly require freezing to ensure the stability of the active pharmaceutical ingredients (APIs). At commercial scale, freezing is typically carried out over the course of days in pallets comprising tens of thousands of vials. The selected process conditions have to ensure both complete freezing in…
Kankan Qin, Corentin Eschenbrenner, Felix Ginot, Dmytro Dedovets + 3 more
Cryopreservation is the only fully established procedure to extend the lifespan of living cells and tissues, a key to activities spanning from fundamental biology to clinical practice. Despite its prevalence and impact, central aspects of cryopreservation, such as the cell’s physico-chemical environment during…
Menno Demmenie, Paul Kolpakov, Boaz van Casteren, Dirk Bakker + 2 more
'Daniel Bonn' 'Noushine Shahidzadeh'] The freezing of water is one of the major causes of mechanical damage in materials during wintertime; surprisingly this happens even in situations where water only partially saturates the material so that the ice has room to grow. Here we perform freezing experiments in cylindrical…
Christopher Myers, Alan Chen
A new potential termed the Fluctuating Density (FD) model is presented as an alternative to traditional fixed partial-charge force fields for describing RNA nucleobase interactions within a molecular mechanics framework. Instead of atom-centered point charges, we take inspiration from fluctuating charge models and use…
Shannon N. Tessier, Omar Haque, Casie A. Pendexter, Stephanie E.J. Cronin + 7 more
The current liver organ shortage has pushed the field of liver transplantation to develop new methods to prolong the preservation time of livers from the current clinical standard of static cold storage. Our approach, termed partial freezing, aims to induce a thermodynamically stable frozen state at deeper storage…
Jing Ling, Yong Du, W. Peter Wuelfing, Nicole Buist + 4 more
Protein drugs exhibit challenges of biophysical and biochemical instability due to their structural complexity and rich dynamics. Solid-state biologics aim to enhance stability by increasing molecular rigidity within the formulation matrix, representing a primary category of drug products alongside sterile liquid…
Abdallah W. Abdelhady, David W. Mittan-Moreau, Patrick L. Crane, Matthew J. McLeod + 2 more
Damage from ice and potential toxicity of ice-inhibiting cryoprotective agents (CPAs) are key issues in assisted reproduction using cryopreserved oocytes and embryos. We use synchrotron-based time-resolved x-ray diffraction and tools from protein cryocrystallography to characterize ice formation within bovine oocytes…
Naomi Martin, Paul Olsen, Jacob Quon, Jazmin Campos + 37 more
Image-based spatial transcriptomics platforms are powerful tools often used to identify cell populations and describe gene expression in intact tissue. Spatial experiments return large, high-dimensional datasets and several open-source software packages are available to facilitate analysis and visualization. The…
Matthew J. Powell‐Palm, Anthony N. Consiglio
- 1 J. Mike Walker '66 Department of Mechanical Engineering, Texas A&M University, College Station, TX, USA 2 Department of Materials Science & Engineering, Texas A&M University, College Station, TX, USA - 3 Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA 4 BioChoric Inc., Bozeman…
Authors not listed
Encoding information in molecular arrangements on DNA origami nanostructures (DONs) provides the basis for novel concepts in molecular data storage and computing. To preserve their integrity over long timescales, the information-carrying DONs are often stored in a frozen state. Here, we investigate the effect of…
Jack Jennings, Sanja Bojić, Lukas Breitwieser, Alex Sharpe + 1 more
The cryopreservation of biological materials is a highly complex process, as it involves numerous factors such as the cooling and thawing procedures, the administration of cryoprotective agents (CPAs), as well as the type and composition of cells. While theoretical work has yielded a better understanding of the…
Gangadhara Boregowda, Panchatcharam Mariappan
Cryoablation is a minimally invasive and efficient therapy option for liver cancer. Liquid nitrogen was used to kill the unwanted cells via freezing. One of the challenges of cryosurgery is to destroy the complete tumor without damaging the surrounding healthy cells when the tumor is large. To overcome this challenge…