21 papers · ranked by Valyu relevance
Sarah Genon, Andrew Reid, Robert Langner, Katrin Amunts + 1 more
'Simon B. Eickhoff'] Many brain regions have been defined, but a comprehensive formalization of each region’s function in relation to human behavior is still lacking. Current knowledge comes from various fields, which have diverse conceptions of ‘functions’. We briefly review these fields and outline how the…
Luiz Pessoa
What is the relationship between brain and behavior? The answer to this question necessitates characterizing the mapping between structure and function. The aim of this paper is to discuss broad issues surrounding the link between structure and function in the brain that will motivate a network perspective to…
Authors not listed
Molecular mechanisms governing initiation steps of the assembly of thousands of endogenous multi-protein complexes (EMCs) remain incompletely understood. Here, multiple lines of observations are reported reflecting the biological functions-aligned initiation sequence of hybrid assembly pathways (HAPs) of EMCs. HAPs…
Jiawei Zhang
In this paper, we will provide an introduction to the brain structure and function. Brain is an astonishing living organ inside our heads, weighing about 1.5kg, consisting of billions of tiny cells. The brain enables us to sense the world around us (to touch, to smell, to see and to hear, etc.), to think and to respond…
Caroline Nettekoven, Da Zhi, Ladan Shahshahani, Ana Lúısa Pinho + 3 more
The human cerebellum is activated by a wide variety of cognitive and motor tasks. Previous functional atlases have relied on single task-based or resting-state fMRI datasets. Here, we present a functional atlas that integrates information from 7 large-scale datasets, outperforming existing group atlasses. The new atlas…
Jie Huang
The highly evolved human brain comprises numerous functional systems, ranging from essential sensory, motor, attention and memory networks to higher-order cognitive functions like reasoning and language. Although these neural systems and cognitive functions are separately distributed across the entire brain, they are…
Zifan Wang, Paule-J Toussaint, Alan C Evans, Xi Jiang
Independent brain regions in neuroanatomy achieve a specific function through connections. As one of the significant morphological features of the cerebral cortex, previous studies have found significant differences in the structure and function of the cerebral gyri and sulci, which provides a basis for us to study the…
Rocco Chiou, John Duncan, Elizabeth Jefferies, Matthew A. Lambon Ralph
Implementing cognitive control relies on neural representations that are inherently high-dimensional and distribute across multiple subregions in the prefrontal cortex (PFC). Traditional approaches tackle prefrontal representations by reducing them into a unidimensional measure (univariate amplitude) or using them to…
VR Karolis, M Corbetta, M Thiebaut de Schotten
Functional lateralisation is a fundamental principle of the human brain. However, a comprehensive taxonomy of functional lateralisation and its organisation in the brain is missing. We report the first complete map of functional hemispheric asymmetries in the human brain, reveal its low dimensional structure, and its…
Ethan Danielli, Nicholas Simard, Carol A. DeMatteo, Dinesh Kumbhare + 2 more
'Stephan Ulmer' 'Michael D. Noseworthy'] The human brain is an exceptionally complex organ that is comprised of billions of neurons. Therefore, when a traumatic event such as a concussion occurs, somatic, cognitive, behavioral, and sleep impairments are the common outcome. Each concussion is unique in the sense that…
Benjamin Y. Hayden
The parcellation of the primate cerebral cortex into numbered regions, based on cytoarchitecture, began with the pioneering research of neuroanatomist Kobrinian Brodmann (Brodmann, 1909; Loukas et al., 2011). While the borders between regions have changed somewhat, and in some cases continue to be disputed, the idea of…
Joseph M. Orr, Harry R. Smolker, Marie T. Banich, Sam Gilbert
The goal of the current study was to examine the pattern of anatomical connectivity of the human frontal pole so as to inform theories of function of the frontal pole, perhaps one of the least understood region of the human brain. Rather than simply parcellating the frontal pole into subregions, we focused on examining…
Marisa K. Heckner, Edna C. Cieslik, Simon B. Eickhoff, Julia A. Camilleri + 2 more
Healthy aging is associated with changes in cognitive performance including executive functions (EFs) and their associated brain activation patterns. However, it has remained unclear which EF-related brain regions are affected consistently, because the results of pertinent neuroimaging studies and earlier meta-analyses…
Matthieu M. de Wit, Heath E. Matheson
Mainstream cognitive neuroscience aims to build mechanistic explanations of behavior by mapping abilities described at the organismal level via the subpersonal level of computation onto specific brain networks. We provide an integrative review of these commitments and their mismatch with empirical research findings.…
Matteo Monticelli, Pietro Zeppa, Marco Mammi, Federica Penner + 3 more
'Antonio Melcarne' 'Francesco Zenga' 'Diego Garbossa'] When discussing “mentalization,” we refer to a very special ability that only humans and few species of great apes possess: the ability to think about themselves and to represent in their mind their own mental state, attitudes, and beliefs and those of others. In…
Sarah F. Muldoon, Fabio Pasqualetti, Shi Gu, Matthew Cieslak + 3 more
'Scott T. Grafton' 'Jean M. Vettel' 'Danielle S. Bassett'] The ability to modulate brain states using targeted stimulation is increasingly being employed to treat neurological disorders and to enhance human performance. Despite the growing interest in brain stimulation as a form of neuromodulation, much remains unknown…
Tales Alexandre Aversi-Ferreira, Mariana Ferreira Pereira de Araújo, Danielly Bandeira Lopes, Hisao Nishijo
primates’ parietal lobe: A review História, citoarquitetura e neuropsicologia do lobo parietal de primatas humanos e não humanos – uma revisão Authors: ['Tales Alexandre Aversi-Ferreira' 'Mariana Ferreira Pereira de Araújo' 'Danielly Bandeira Lopes' 'Hisao Nishijo'] This strict localizationism had and still has its…
Revati Shriram, M. Sundhararajan, Nivedita Daimiwal
To understand 'Working of Human Brain', measurements related to the brain function are required. These measurements should be possibly non-invasive. Brain should be disturbed as less as possible during the measurement. Integration of various modalities plays a vital role in understanding the cognitive and the…
Revati Shriram, Mahalingam Sundhararajan, Nivedita Daimiwal
— Action, cognition, emotion and perception can be mapped in the brain by using set of techniques. Translating unimodal concepts from one modality to another is an important step towards understanding the neural mechanisms. This paper provides a comprehensive survey of multimodal analysis of brain signals such as fMRI…
Authors not listed
The GluK1 receptor, an ionotropic glutamate receptor, operates as a ligand-gated ion channel. Opioids stand as the most potent pain-relieving medications currently prescribed in the medical field. Inhibiting this receptor is anticipated to result in a reduction of dopamine release in the Nucleus Accumbens, effectively…
Authors not listed
TIMP2 (Tissue Inhibitor of Metalloproteinase-2) plays a crucial role in hippocampal neuroplasticity and cognitive function through MMP-independent signaling. Despite its therapeutic promise, TIMP2 has long been considered 'undruggable' due to its cryptic surface topology and lack of canonical active sites. We present a…