24 papers · ranked by Valyu relevance
Daniel F. Voytas, Caixia Gao, Susan R. McCouch
As Caixia Gao and Dan Voytas explain, new techniques make it possible to precisely edit plant genomic DNA, providing opportunities to create crop varieties that will help meet the challenges facing agriculture, including an expanding world population and environmental change.
Suliman Khan, Muhammad Wajid Ullah, Rabeea Siddique, Ghulam Nabi + 3 more
'Sehrish Manan' 'Muhammad Yousaf' 'Hongwei Hou'] In the past century, the recombinant DNA technology was just an imagination that desirable characteristics can be improved in the living bodies by controlling the expressions of target genes. However, in recent era, this field has demonstrated unique impacts in bringing…
Khalid E. M. Sedeek, Ahmed Mahas, Magdy Mahfouz
To improve food security, plant biology research aims to improve crop yield and tolerance to biotic and abiotic stress, as well as increasing the nutrient contents of food. Conventional breeding systems have allowed breeders to produce improved varieties of many crops; for example, hybrid grain crops show dramatic…
Majid Sohrabi, Amir M. Fathollahi-Fard, Vasilii A. Gromov
> Abstract. Genetic Algorithms (GAs) are known for their efficiency in solving combinatorial optimization problems, thanks to their ability to explore diverse solution spaces, handle various representations, exploit parallelism, preserve good solutions, adapt to changing dynamics, handle combinatorial diversity, and…
Giulliana Augusta Rangel Gonçalves, Raquel de Melo Alves Paiva
The ability to make site-specific modifications to the human genome has been an objective in medicine since the recognition of the gene as the basic unit of heredity. Thus, gene therapy is understood as the ability of genetic improvement through the correction of altered (mutated) genes or site-specific modifications…
Ramsey Affifi
This paper describes some likely semiotic consequences of genetic engineering on what Gregory Bateson has called “the mental ecology” ([6]) of future humans, consequences that are less often raised in discussions surrounding the safety of GMOs (genetically modified organisms). The effects are as follows: an increased…
Prakash M. Niraula, Vincent N. Fondong, Attila L. Ádám, Lorant Király
Plant viruses cause yield losses to crops of agronomic and economic significance and are a challenge to the achievement of global food security. Although conventional plant breeding has played an important role in managing plant viral diseases, it will unlikely meet the challenges posed by the frequent emergence of…
Jonathan Calles, Isaac Justice, Detravious Brinkley, Alexa Garcia + 1 more
One challenge in engineering organisms is guaranteeing system behavior over many generations. Spontaneous mutations that arise before or during use can impact heterologous genetic functions, disrupt system integration, or change organism phenotype. Here, we propose restructuring the genetic code itself such that all…
Maciej Maselko, Stephen C. Heinsch, Jeremy Chacón, William Harcombe + 1 more
We introduce a novel approach to engineer a genetic barrier to sexual reproduction between otherwise compatible populations. Programmable transcription factors drive lethal gene expression in hybrid offspring following undesired mating events. As a proof of concept, we target the ACT1 promoter of the model organism…
Authors not listed
In this report, we examine the extensive research landscape of CRISPR with an emphasis on CRISPR therapeutics and showcase our results from an in-depth analysis of the most up-to-date scientific information consisting of more than 53,000 publications encompassing academic journal articles and patents, spanning nearly…
David B Resnik, Daniel B Vorhaus
In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism.…
Igor Muniz Soares, Fernando H. F. Camargo, Adriano Marques
With the constant advancements of genetic engineering, a common concern is to be able to identify the lab-of-origin of genetically engineered DNA sequences. For that reason, AltLabs has hosted the Genetic Engineering Attribution Challenge to gather many teams to propose new tools to solve this problem. Here we show our…
Katie Fan
Metabolic engineering in plants has emerged as a powerful approach to address global challenges in agriculture, nutrition, and sustainability. This comprehensive review explores cutting-edge strategies for manipulating primary and secondary metabolic pathways in plants, utilizing advanced genetic modification tools to…
Michelle L. Johnson, Bruce A. Hay, Maciej Maselko
Population-scale genome editing can be used to alter the composition or fate of wild populations. One approach to achieving these aims utilizes a synthetic gene drive element—a multi-gene cassette—to bring about an increase in the frequency of an existing allele. However, the use of gene drives is complicated by the…
Bryan Bartley, Jacob Beal, Jonathan R. Karr, Elizabeth A. Strychalski
'Elizabeth A. Strychalski'] Engineering the entire genome of an organism enables large-scale changes in organization, function, and external interactions, with significant implications for industry, medicine, and the environment. Improvements to DNA synthesis and organism engineering are already enabling substantial…
Nicolas O. Rode, Virginie Courtier-Orgogozo, Florence Débarre
CRISPR-based homing gene drive is a genetic control technique aiming to modify or eradicate natural populations. This technique is based on the release of individuals carrying an engineered piece of DNA that can be preferentially inherited by the progeny. Developing countermeasures is important to control the spread of…
Quanjiang Ji, Hongyuan Zhang, Yifei Zhang, Wei-Xiao Wang + 4 more
New therapeutic strategies for rapid and effective treatment of tuberculosis are highly desirable, and their development can be drastically accelerated by facile genetic manipulation methods in Mycobacterium tuberculosis. CRISPR base editors allow for rapid, robust, and programmed single base substitutions and gene…
Richard Gomulkiewicz, Micki L. Thies, James J. Bull
Gene drives offer the possibility of altering and even suppressing wild populations of countless plant and animal species, and CRISPR technology now provides the technical feasibility of engineering them. However, population-suppression gene drives are prone to select resistance, should it arise. Here we develop…
Ricard V. Solé
Our planet is experiencing an accelerated process of change associated to a variety of anthropogenic phenomena. The future of this transformation is uncertain, but there is general agreement about its negative unfolding that might threaten our own survival. Furthermore, the pace of the expected changes is likely to be…
Zahir Ali, Maged Serag, Gozde Demirer, Bruno Torre + 4 more
Efficient delivery of DNA, RNA, and genome engineering machinery to plant cells will enable efforts to genetically modify plants for global food security, sustainable energy production, synthetic biology applications, and climate change resilience. For the delivery of functional genetic units into plant cells, charged…
Authors not listed
The rise of antibiotic resistance has necessitated the exploration of unconventional sources for novel antimicrobial agents. One emerging novel frontier is "de-extinct" molecules – bioactive peptides, antibiotics, and other bioactive agents reconstructed from ancient or extinct organisms – a groundbreaking convergence…
Marilena De Almeida, Jonathan M. Henshaw, Adam G. Jones, Xiaoyan Long
Artificial gene drives offer a promising approach for controlling populations of agricultural pests, invasive species and disease vectors, such as malaria-carrying mosquitoes. Gene-drive alleles induce a transmission bias, meaning there is a greater than 50% probability that they will be inherited by offspring…
Jakub Vincalek, Sean Walton, Ben Evans
—Genetic algorithms have been developed for decades by researchers in academia and perform well in engineering applications, yet their uptake in industry remains limited. In order to understand why this is the case, the opinions of users of engineering design tools were gathered. The results from a survey showing the…
Michael W. Deem
Jim Shapiro synthesizes a great many observations about the mechanisms of evolution to reach the remarkable conclusion that large‐scale modification, exchange, and rearrangement of the genome are common and should be viewed as fundamental features of life [1]. In other words, the genome should be viewed not as mostly…