26 papers · ranked by Valyu relevance
David B Resnik, Daniel B Vorhaus
In this article we examine four objections to the genetic modification of human beings: the freedom argument, the giftedness argument, the authenticity argument, and the uniqueness argument. We then demonstrate that each of these arguments against genetic modification assumes a strong version of genetic determinism.…
Daniel F. Voytas, Caixia Gao, Susan R. McCouch
As Caixia Gao and Dan Voytas explain, new techniques make it possible to precisely edit plant genomic DNA, providing opportunities to create crop varieties that will help meet the challenges facing agriculture, including an expanding world population and environmental change.
Pablo Rozas, Eduardo I. Kessi-Pérez, Claudio Martínez
Genetic modification of living organisms has been a prosperous activity for research and development of agricultural, industrial and biomedical applications. Three decades have passed since the first genetically modified products, obtained by transgenesis, become available to the market. The regulatory frameworks…
Michelle L. Johnson, Bruce A. Hay, Maciej Maselko
Population-scale genome editing can be used to alter the composition or fate of wild populations. One approach to achieving these aims utilizes a synthetic gene drive element—a multi-gene cassette—to bring about an increase in the frequency of an existing allele. However, the use of gene drives is complicated by the…
Adugnaw Admas, Smegnew Melese, Amare Genetu
Detection of genetically modified organisms (GMOs) in crops is an important issue for all the subjects involved in seed quality control and customer’s right. Due to the increasing number of GMOs research and development activity in the globe during the past few years, it has become necessary to screen and regulate…
Rakesh Kumar Yadav, Manoj Kumar Tripathi, Sushma Tiwari, Niraj Tripathi + 7 more
'Niraj Tripathi' 'Ruchi Asati' 'Shailja Chauhan' 'Prakash Narayan Tiwari' 'Devendra K. Payasi' 'Balazs Barna' 'Hakim Manghwar' 'Wajid Zaman'] Genome editing aims to revolutionise plant breeding and could assist in safeguarding the global food supply. The inclusion of a 12-40 bp recognition site makes mega nucleases the…
Tien Van Vu, Swati Das, Goetz Hensel, Jae-Yean Kim
Main conclusion Genome editing offers revolutionized solutions for plant breeding to sustain food production to feed the world by 2050. Therefore, genome-edited products are increasingly recognized via more relaxed legislation and community adoption. Abstract The world population and food production are…
Nassim Nicholas Taleb, Rupert Read, Raphaël Douady, Joseph Norman + 1 more
'Yaneer Bar-Yam'] Abstract—The precautionary principle (PP) states that if an action or policy has a suspected risk of causing severe harm to the public domain (affecting general health or the environment globally), the action should not be taken in the absence of scientific near-certainty about its safety. Under these…
Aayushi Patel, Andrew Miles, Tara Strackhouse, Logan Cook + 5 more
'Sining Leng' 'Shrina Patel' 'Kelsey Klinger' 'Sairam Rudrabhatla' 'Shobha D. Potlakayala'] Agriculture has supported human life from the beginning of civilization, despite a plethora of biotic (pests, pathogens) and abiotic (drought, cold) stressors being exerted on the global food demand. In the past 50 years, the…
Majid Sohrabi, Amir M. Fathollahi-Fard, Vasilii A. Gromov
> Abstract. Genetic Algorithms (GAs) are known for their efficiency in solving combinatorial optimization problems, thanks to their ability to explore diverse solution spaces, handle various representations, exploit parallelism, preserve good solutions, adapt to changing dynamics, handle combinatorial diversity, and…
Authors not listed
In this report, we examine the extensive research landscape of CRISPR with an emphasis on CRISPR therapeutics and showcase our results from an in-depth analysis of the most up-to-date scientific information consisting of more than 53,000 publications encompassing academic journal articles and patents, spanning nearly…
Pamela C. Ronald, Sophien Kamoun
In this Essay, Pam Ronald describes how basic research advances have been translated into crop improvement, explores some lessons learned, and discusses the potential for plant genetic improvement technologies to contribute to improved food security and agricultural sustainability.
Mohammed Aledhari, Mohamed Rahouti
Future Directions Authors: ['Mohammed Aledhari' 'Mohamed Rahouti'] Abstract—Gene and RNA editing methods, technologies, and applications are emerging as innovative forms of therapy and medicine, offering more efficient implementation compared to traditional pharmaceutical treatments. Current trends emphasize the urgent…
Katie Fan
Metabolic engineering in plants has emerged as a powerful approach to address global challenges in agriculture, nutrition, and sustainability. This comprehensive review explores cutting-edge strategies for manipulating primary and secondary metabolic pathways in plants, utilizing advanced genetic modification tools to…
Authors not listed
Assisted reproductive technologies (ART) have revolutionized the field of reproductive medicine, offering hope to millions of individuals and couples facing fertility problems. From artificial insemination to cutting-edge gene editing techniques, ART enhances reproductive efficiency, transforming the landscape of…
Haroon Butt, Jose Luis Moreno Ramirez, Magdy Mahfouz
Synthetic directed evolution via localized sequence diversification and the simultaneous application of selection pressure is a promising method for producing new, beneficial alleles that affect traits of interest in diverse species; however, this technique has rarely been applied in plants. Developing systems to…
Georg Oberhofer, Tobin Ivy, Bruce A Hay
Self-limiting gene drive allows control over the spread and fate of linked traits. Cleave and Rescue (ClvR) elements create self-sustaining drive and comprise a DNA sequence-modifying enzyme (Cas9-gRNAs, Cleaver) that disrupts an essential gene, and a tightly linked, uncleavable version of the essential gene (Rescue).…
Brendan Cody-Kenny, Stephen Barrett
In Search Based Software Engineering, Genetic Programming has been used for bug fixing, performance improvement and parallelisation of programs through the modification of source code. Where an evolutionary computation algorithm, such as Genetic Programming, is to be applied to similar code manipulation tasks, the…
Søren Knudsen, Toni Wendt, Christoph Dockter, Hanne C. Thomsen + 30 more
Novel crop improvement methodologies, including the exploitation of natural genetic variation, are urgently required to feed our rapidly growing human population in the context of global climate change. Here we describe a ‘Fast Identification of Nucleotide variants by DigITal PCR’ (FIND-IT) method for the rapid…
Authors not listed
Nature employs proteins as molecular machines to orchestrate numerous intricate biological processes. Natural proteins are primarily synthesized from 22 proteinogenic amino acids. In principle, developing abiotic proteins with novel non-proteinogenic residues can expand their functional space, enabling the discovery of…
Michael W. Deem
Jim Shapiro synthesizes a great many observations about the mechanisms of evolution to reach the remarkable conclusion that large‐scale modification, exchange, and rearrangement of the genome are common and should be viewed as fundamental features of life [1]. In other words, the genome should be viewed not as mostly…
Lisandro Milocco, Tobias Uller
Understanding, predicting, and controlling the phenotypic consequences of genetic and environmental change is essential to many areas of fundamental and applied biology. In evolutionary biology, the generative process of development is a major source of organismal evolvability that constrains or facilitates adaptive…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Authors not listed
Site-specific modifications of native-sequence proteins are technologies that underpin progresses in chemical biology, diagnostics and next-generation biotherapeutics. However, the pursuit of site-specificity has often come at the expense of scalability and usability, ultimately limiting translational potential of a…
Frank Technow, Dean Podlich, Mark Cooper
Plant breeding operates within a highly complex genetic landscape determined by gene effects emerging through biological networks and their interactions with the environment. This environment is not constant but subject to short-term fluctuations and long-term shifts. This significantly complicates the task of plant…
Juan Li, Claudia Bank
Dominance is usually considered a constant value that describes the relative difference in fitness or phenotype between heterozygotes and the average of homozygotes at a focal polymorphic locus. However, the observed dominance can vary with the genetic background of the focal locus. Here, alleles at other loci modify…