10 papers · ranked by Valyu relevance
Sreemoyee Mitra, Damini, Mahima Devi, Sreyosi Guha Niyogi + 4 more
Liver cancer, mainly hepatocellular carcinoma (HCC), remains a global health burden marked by poor prognosis with limited therapeutic efficacy, and high recurrence rates. HCC remains one of the most lethal malignancies worldwide, with limited therapeutic options and high resistance to conventional treatments. Despite…
Daniel Laspisa, Rubens Diogo, Rafael E. Venado, Tess Kern + 3 more
Key Message We mapped key regions of the maize genome that influence the formation of aboveground (aerial) roots, which in some varieties have been associated with symbiosis with nitrogen-fixing bacteria. Abstract Modern agriculture relies heavily on chemically synthesized nitrogen fertilizers, which ensure high yields…
Behnaz Soleimani, Anne-Kathrin Pfrieme, Ulrike Beukert, Heike Lehnert + 8 more
Key message Integrating high-throughput phenotyping with multiple complementary GWAS models reduces method-dependent bias and enables reliable identification of novel loci and elite germplasm for durable yellow and leaf rust resistance in wheat. Abstract The causal agents of yellow and leaf rust in wheat, Puccinia…
Colin Vullioud, Diana Geweiler, Joerg Melzheimer, Sonja Heinrich + 3 more
In populations with low genetic diversity, the capacity to adapt to environmental change is limited. While epigenetic mechanisms can generate phenotypic plasticity, their role in mediating adaptive life-history transitions in the wild is largely unknown. Here, we show that in adult Namibian cheetahs (Acinonyx jubatus…
Mohamed Mosalam, Hannah Robinson, Steffen Windpassinger, Rod J. Snowdon + 1 more
Key message Cold tolerance in sorghum is largely stage- and environment-specific yet partially shared genetic control allows improvement across developmental stages with mostly modest, trait-specific trade-offs. Abstract Cold tolerance is a major constraint to sorghum production in temperate environments, and its…
Beatrice Fois, Alice Dalla Vecchia, Giovanni Campiello, Rossano Bolpagni + 1 more
The study of functional trait variation is increasingly used to understand macrophyte adaptation, as traits reflect organismal performance under different ecosystem conditions. Phenotypic expression results from the interplay of genetic and environmental factors: genetics provides the molecular basis for heritable…
Christopher Mark LaCoursiere, Zachary Stayn, Hannah Hepner, Sneham Tiwari + 6 more
Advancements in next-generation sequencing have led to the discovery of hundreds of human epilepsy gene associations. Newly associated genes require functional validation to establish causation and to inform patient treatment in the clinic. A recent exome sequencing trio analysis identified predicted protein-altering…
John McEnany, Benjamin H. Good
In fluctuating environments, the fates of new mutations depend on the fitness tradeoffs they experience across multiple environmental conditions. Selection on these tradeoffs is well-understood when mutations compete in isolation, but much less is known in the empirically relevant case where multiple mutations compete…
Stan Oome, Mohammad Ghanbari
Allelic heterogeneity is a term from genetics which means that alleles that differ in primary sequence can have a similar phenotypic outcome. In other words, they are functional equivalents, and they naturally appear through convergent evolution under selection. Current GWAS has trouble detecting these instances, as…
Yasin Topcu, Alper Adak, Halim Can Kayikci, Serkan Aydin + 6 more
Key message Tomato fruit weight is primarily controlled by stable genetic effects and domestication-/improvement-associated loci, including prominent chromosome 5 signals, and integrating SNP, INDEL, and SV diversity improves candidate-locus discovery, biological interpretation, and genomic prediction across…