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Search · four archives
20 papers · ranked by Valyu relevance
Fangyuan Zhu, Huaijun Tu, Tingtao Chen, Cuixiang Wan + 1 more
Depression is a kind of worldwide mental illness with the highest morbidity and disability rate, which is often accompanied by gastrointestinal symptoms. Experiments have demonstrated that the disorder of the intestinal microbial system structure plays a crucial role in depression. The gut-brain axis manifests a…
Ahmed Eltokhi, Iris E. Sommer
Depression is a severe mental disorder that places a significant economic burden on public health. The reciprocal link between the trillions of bacteria in the gut, the microbiota, and depression is a controversial topic in neuroscience research and has drawn the attention of public interest and press coverage in…
Meiling Wang, Zhaoqi Song, Shirong Lai, Furong Tang + 2 more
Depression is one of the most prevalent mental disorders today. Over the past decade, there has been considerable attention given to the field of gut microbiota associated with depression. A substantial body of research indicates a bidirectional communication pathway between gut microbiota and the brain. In this…
Ameer Luqman, Mei He, Adil Hassan, Mehtab Ullah + 6 more
Depression is considered a multifaceted and intricate mental disorder of growing concern due to its significant impact on global health issues. The human gut microbiota, also known as the “second brain,” has an important role in the CNS by regulating it through chemical, immunological, hormonal, and neurological…
Zihua Li, Jingxi Sun, Jinlong Yang, Panpan Han + 4 more
Depression, a psychiatric disorder with significant morbidity and mortality, has a complex etiology. Recent advances in microbiome research have highlighted the potential role of gut microbiota in depression pathogenesis. This study utilized shotgun metagenomic sequencing to compare the fecal microbiota of 28…
Yuchen Zhang, Wenkai Lai, Meiling Wang, Shirong Lai + 3 more
Depression is a common mental disorder worldwide, and its pathogenesis remains incompletely understood. However, increasing evidence suggests that gut microbiota play a significant role in the development of depression through the gut-brain-microbiota axis. However, due to the substantial individual variability in gut…
Jiayu Li, Junyu Wang, Meiyu Wang, Li Zheng + 5 more
'Fangfang Wang' 'Li Zhu' 'Rizhao Pang' 'Anren Zhang'] Depression is a common psychological disease, which has become one of the main factors affecting human health. It has a serious impact on individuals, families, and society. With the prevalence of COVID-19, the incidence of depression has further increased…
Yangbo Zhang, Changwei Liu, Qi Zhu, Hui Wu + 3 more
Depression, a serious mental illness, is characterized by high risk, high incidence, persistence, and tendency to relapse, posing a significant burden on global health. The connection between depression and gut microbiota is an emerging field of study in psychiatry and neuroscience. Understanding the gut-brain axis is…
Xin Zhou, Ariel B. Ganz, Andre Rayner, Tess Yan Cheng + 10 more
Depression is a leading cause of disability worldwide yet its underlying factors, particularly microbial associations, are poorly understood. We examined the longitudinal interplay between the microbiome and immune system in the context of depression during an immersive psychosocial intervention. 142 multi-omics…
Madelaine Leitman, Will Katza, David Zhang, Shrey Pawar + 3 more
Altered serotonin signaling is a well-established contributor to depression, with the serotonin transporter gene (SERT) playing a critical role in regulating serotonin reuptake. Mice lacking SERT (SERT -/-) serve as a robust model for depression, exhibiting significant depressive-like behaviors compared to littermate…
Isabella Schapira, Lillian Russo-Savage, Terdha Narla, Maggie O'Neill + 3 more
Despite the fact that tryptophan is an essential amino acid that humans typically obtain through diet, there are several interesting tryptophan dynamics at play in the body. Quantifying and understanding these dynamics are crucial in studies of depression, autism spectrum disorder, and other disorders that involve…
Thomaz F. S. Bastiaanssen, Thomas P. Quinn, Amy Loughman
There has been a growing acknowledgement of the involvement of the gut microbiome the collection of microbes that reside in our gut - in regulating our mood and behaviour. This phenomenon is referred to as the microbiome-gut-brain axis. While our techniques to measure the presence and abundance of these microbes have…
Alegre, Enso Onill Torres
The gut microbiota has emerged as a fundamental regulator of sleep physiology, acting through interconnected neural, immune, and endocrine pathways. This bidirectional relationship influences neurotransmitter production, circadian rhythms, inflammatory activity, and metabolic balance. Changes in microbial composition…
Xiaoran Han
Due to time constraints, mental health professionals in China are unable to offer patients prolonged talk therapy, leaving a gap in care for patients with psychological disorders, including aberrant sleep and eating patterns, maladaptive explanatory styles, and gastrointestinal dysfunction. To bridge this gap in care…
Thomaz F. S. Bastiaanssen, Thomas P. Quinn, Amy Loughman
In this companion piece to Bugs as Features (part I), we present techniques from adjacent and disparate fields to enrich and inform the analysis of microbiome-gut-brain-axis data. Emerging techniques built specifically for the microbiome-gut-brain axis are also demonstrated. All of these methods are contextualised to…
Authors not listed
The intricate bidirectional communication between mitochondria and the gut microbiota – termed mitochondria-microbiome crosstalk – plays a pivotal role in regulating host metabolism, immune responses, and overall physiological homeostasis. Emerging evidence highlights how microbial-derived metabolites, such as…
Authors not listed
One Health seeks to integrate and balance the health of humans, animals, and environmental systems. These three spheres are intricately interconnected through microbiomes, which are universally present and exchange microbes and genes, influencing not only human and animal health but also key environmental…
Authors not listed
The gut microbiota produces metabolites that are important for host physiology and have critical roles in the development of diseases, such as metabolic disorders, cardiovascular diseases, and cancer. Here, we developed a gas chromatography-coupled to tandem mass spectrometry (GC-MS/MS) method for the quantification of…
Maryam Shahabikargar
Mental health disorders may cause severe consequences on all the countries' economies and health. For example, the impacts of the COVID-19 pandemic, such as isolation and travel ban, can make us feel depressed. Identifying early signs of mental health disorders is vital. For example, depression may increase an…
Todor Koev, Hou Hei Chung, Caitlin Wright, Evie Banister + 2 more
The human gut has emerged as a highly promising candidate for predicting the onset of pathologies and monitoring disease pro-gression. The gut microbiota plays a crucial role in maintaining gut homeostasis, modulating immune responses, metabolizing nutri-ents and regulating host physiology. These functions have been…