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Search · four archives
20 papers · ranked by Valyu relevance
Zhang Ruohan, Wang Ruting, Wu Hongxi, Huang Zhenjin + 4 more
The global prevalence of depression and anxiety continues to rise, with major depressive disorder and anxiety disorders estimated to affect approximately 3.1 and 4.8% of the world’s population. Yet current pharmacological treatments demonstrate limited efficacy. This limitation has spurred extensive research into…
Jiaqi Cao, Jiayang Ma, Xu Zha, Xiaomei Bian + 3 more
Major depressive disorder (MDD) ranks as a primary contributor to global ill health and disability, with treatments often proving insufficient. Recent study has increasingly found a strong correlation between gut microbiome diversity and mood-related behaviors, including MDD. Depression can alter gut microbiota (GM)…
Pegah Ataei, Hamidreza Kalantari, Tamara S. Bodnar, Raymond J. Turner
The human gut microbiome has emerged as a pivotal modulator of brain function and mental health, acting through intricate bidirectional communication along the gut-brain axis. Mounting evidence suggests that microbial communities influence neurodevelopment, neurotransmission, and behavior via pathways involving the…
Jhommara Bautista, Camila Hidalgo-Tinoco, Miranda Di Capua Delgado, Juliana Viteri-Recalde + 2 more
Anxiety and depressive disorders rank among the most prevalent psychiatric conditions worldwide, yet remission rates remain unsatisfactory despite advances in pharmacological and psychotherapeutic interventions. The gut-brain axis has emerged as a transformative framework for understanding these disorders, emphasizing…
Jiamin Fu, Yuchi Zhang, Jing Gao, Ming Lan + 12 more
Background The gut microbiota plays a crucial role in the bidirectional communication between the gut and the brain. Although there has been much discussion in recent years on the link between depression and fecal microbiota transplantation (FMT), its effectiveness in treating depression remains debatable. The purpose…
Yinglei Wang, Mengyao Dai, Dongdong Yang, Siyu Fan + 12 more
Electroconvulsive therapy (ECT) is a final procedure for major depressive disorders (MDD). However, the effectiveness of ECT in treating MDD patients varies. Here we identified gut microbiota as a potential restraining factor of ECT efficacy. By using a 5-day electroconvulsive shock (ECS) in depression mouse model of…
Changsheng Jiang, Wedad M. Nageeb, Shumaila Batool, Amro Hashish + 10 more
Title: Summary The gut microbiota-brain axis constitutes a dynamic, bidirectional communication network that integrates neural, endocrine, immune, and metabolic pathways to regulate host physiology and behavior. Accumulating evidence indicates that disturbances within this axis have been consistently associated with…
Muhammad Sohail Khan, Muhammad Faizan, Gabsik Yang, Ki Sung Kang + 1 more
Major depressive disorder (MDD) is a mental illness with high mortality, suicide, and relapse rates that could become the leading cause of health problems worldwide by 2030. The microbiota-gut-brain axis involves bidirectional communication between the human gut microbiota and the central nervous system (CNS). The gut…
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li + 14 more
Inflammatory bowel diseases (IBDs) are frequently accompanied by anxiety and depression, largely driven by perturbed gut-brain axis signaling. However, current oral therapies remain constrained by the spatial and functional separation between intestinal inflammation and central nervous system dysfunction. Here, we…
Alegre, Enso Onill Torres
The gut microbiota has emerged as a fundamental regulator of sleep physiology, acting through interconnected neural, immune, and endocrine pathways. This bidirectional relationship influences neurotransmitter production, circadian rhythms, inflammatory activity, and metabolic balance. Changes in microbial composition…
Monica A. Tschang, Ronin Deo-Campo Vuong, Baylee Eilers, Denise Chac + 9 more
The microbiome-gut-brain axis is a mediator of stress-related disorders. The number of preclinical studies exploring the potential causal mechanism of this connection using fecal microbiota transplantation (FMT) is growing. However, the most common method for delivering fecal transplants in rodent models is still oral…
Aatsinki Anna-Katariina, James M Collins, Munukka Eveliina, Nolvi Saara + 25 more
Behavioural phenotypes have previously been transferred via faecal microbiota transplantation (FMT) from patients with psychiatric disorders to rodents. Studies indicate that the gut microbiota composition may be linked to certain temperament traits, defined as biologically-based differences in emotional reactivity and…
Katherine Bauer Estrada, Karen M. Mancera Azamar, Caoyuanhui Wang, Samanvitha Deepthi Sudi + 7 more
Gut dysbiosis has been implicated in numerous pathological conditions, including neurodevelopmental and neurodegenerative disorders. Recently, dietary interventions targeted at restoring microbial balance have therefore gained attention as potential therapeutic strategies. We recently demonstrated that an encapsulated…
Authors not listed
The intricate bidirectional communication between mitochondria and the gut microbiota – termed mitochondria-microbiome crosstalk – plays a pivotal role in regulating host metabolism, immune responses, and overall physiological homeostasis. Emerging evidence highlights how microbial-derived metabolites, such as…
Marianna Milano, Pietro Hiram Guzzi
Microbiome studies increasingly indicate that disease-associated shifts cannot be understood from compositional changes alone. The functional architecture of microbial communities encoded in patterns of association among microbial gene families may reveal how these systems reorganize across biological conditions. Here…
Kai Jiang, Satabdi Saha, Christine B. Peterson
Numerous studies have shown that microbial metabolites, which represent the products of bacteria in the human gut, play a key role in shaping cancer risk and response to treatment. However, metabolite data typically contain a large proportion of missing values, which may result from either low abundance or technical…
Giulia Perciballi, Ahmad Fall, Federica Granese, Edi Prifti + 1 more
Tabular foundation models (TFMs) achieve strong performance on microbiome abundance data, yet their robustness under realistic distribution shift remains poorly characterized. We introduce a benchmark that evaluates the robustness of TFMs to biologically inspired perturbations across six gut microbiome datasets…
Seungjun Ahn, Quran Wu, Alicia Yang, Zhigang Li
The role of the microbiome in disease pathogenesis is an emerging field with strong evidence suggesting that dysbiosis is associated with precancerous and cancerous states. Microbiome data present substantial challenges for causal mediation analysis due to sparsity, compositional constraints, and latent heterogeneity.…
Sooran Kim, Chan Wang, Soyoung Kwak, Fares Darawshy + 4 more
The influence of environmental exposures, such as air pollution, on human health has become increasingly recognized. A growing body of evidence suggests that the microbiome may mediate these effects, explaining the relationship between the environment and host biology. However, the impact of environmental exposures on…
Authors not listed
The dehydroxylation of catechols represents an important chemical transformation facilitated by gut bacteria in mammals. This reaction is catalyzed by pyranopterin molybdenum enzymes that belong to the DMSO reductase family. Despite their chemical and biological significance, the structure and mechanisms of catechol…