22 papers · ranked by Valyu relevance
Authors not listed
Transformative technologies are enabling the construction of three-dimensional maps of tissues with unprecedented spatial and molecular resolution. Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the…
M Snyder, Shin Lin, Amanda L. Posgai, Mark A. Atkinson + 146 more
'Jennifer Rood' 'Orit Rozenblatt–Rosen' 'Leslie Gaffney' 'Anna Hupalowska' 'Rahul Satija' 'Nils Gehlenborg' 'Jay Shendure' 'Julia Laskin' 'Pehr B. Harbury' 'Nicholas A. Nystrom' 'Jonathan C. Silverstein' 'Ziv Bar‐Joseph' 'Kun Zhang' 'Katy Börner' 'Yiing Lin' 'Richard Conroy' 'Dena Procaccini' 'Ananda L. Roy' 'Ajay…
Katy Börner, Philip D. Blood, Jonathan C. Silverstein, Matthew Ruffalo + 16 more
'Matthew Ruffalo' 'Rahul Satija' 'Sarah A. Teichmann' 'Gloria J. Pryhuber' 'Ravi S. Misra' 'Jeffrey M. Purkerson' 'Jean Fan' 'John W. Hickey' 'Gesmira Molla' 'Chuan Xu' 'Yun Zhang' 'Griffin M. Weber' 'Yashvardhan Jain' 'Danial Qaurooni' 'Yongxin Kong' '' 'Andreas Bueckle' 'Bruce W. Herr II'] The Human BioMolecular…
Bruce W. Herr, Josef Hardi, Ellen M. Quardokus, Andreas Bueckle + 6 more
The Human Reference Atlas (HRA) is defined as a comprehensive, three-dimensional (3D) atlas of all the cells in the healthy human body. It is compiled by an international team of experts that develop standard terminologies linked to 3D reference objects describing anatomical structures. The third HRA release (v1.2)…
Supriya Bidanta, Katy Börner, Bruce W. Herr, Marcell Nagy + 5 more
Functional tissue units (FTUs) form the basic building blocks of organs and are important for understanding and modeling the healthy physiological function of the organ and changes during disease states. In this first comprehensive catalog of FTUs, we document the definition, physical dimensions, vasculature, and…
Katy Börner, Philip D. Blood, Jonathan C. Silverstein, Matthew Ruffalo + 16 more
The Human BioMolecular Atlas Program (HuBMAP) aims to construct a reference 3D structural, cellular, and molecular atlas of the healthy adult human body. The HuBMAP Data Portal (https://portal.hubmapconsortium.org) serves experimental datasets and supports data processing, search, filtering, and visualization. The…
Katy Börner, Philip D. Blood, Jonathan C. Silverstein, Matthew Ruffalo + 16 more
'Matthew Ruffalo' 'Rahul Satija' 'Sarah A. Teichmann' 'Gloria Pryhuber' 'Ravi S. Misra' 'Jeffrey Purkerson' 'Jean Fan' 'John W. Hickey' 'Gesmira Molla' 'Chuan Xu' 'Yun Zhang' 'Griffin Weber' 'Yashvardhan Jain' 'Danial Qaurooni' 'Yongxin Kong' '' 'Andreas Bueckle' 'Bruce W. Herr II'] The Human BioMolecular Atlas Program…
Andreas Bueckle, Bruce W. Herr, Lu Chen, Daniel Bolin + 7 more
The human body contains ∼27-36 trillion cells of up to 10,000 cell types (CTs) within a volume of ∼62-120 liters (males) and 52-89 liters (females). The Human Reference Atlas (HRA) v2.3 provides a quantitative 3D framework of CTs across 73 reference organs and 1,283 3D anatomical structures (ASs). The HRA Cell Type…
Yuqing Mei, Jingjing Wang, Guoji Guo
Recently, in a series of three papers published in Nature, the Human Biomolecular Atlas Program (HuBMAP) consortium reported three multi-model single-cell and spatial atlases.1-3 Each work covered more than a million cells and mapped them to specific locations in the body, providing new standards to study human organs…
Katy Börner, Ellen M. Quardokus, Bruce Herr, Leonard E. Cross + 13 more
'Elizabeth G. Record' 'Yingnan Ju' 'Andreas Bueckle' 'James P. Sluka' 'Jonathan C. Silverstein' 'Kristen Browne' 'Sanjay Jain' 'Clive Wasserfall' 'Marda Jorgensen' 'Jeffrey M. Spraggins' 'Nathan Heath Patterson' 'Mark A. Musen' 'Griffin M. Weber'] Katy Börner1 , Ellen M. Quardokus1 , Bruce W. Herr II1 , Leonard E.…
Katy Börner, Sarah A. Teichmann, Ellen M. Quardokus, James Gee + 32 more
This paper reviews efforts across 16 international consortia to construct human anatomical structures, cell types, and biomarkers (ASCT+B) tables and three-dimensional reference organs in support of a Human Reference Atlas. We detail the ontological descriptions and spatial three-dimensional anatomical representations…
Bryon Drown, Kevin Jooß, Rafael Melani, Cameron Lloyd-Jones + 2 more
A functional understanding of the human body requires structure-function studies of proteins at scale. The chemical structure of proteins is controlled at the transcriptional, translational, and post-translational levels, creating a variety of products with modulated functions within the cell. The term “proteoform”…
José V. Manjón, Sergio Morell-Ortega, Marina Ruiz-Perez, Boris Mansencal + 15 more
'Boris Mansencal' 'Edern Le Bot' 'Marién Gadea' 'Enrique Lanuza' 'Gwénaëlle Catheline' 'Thomas Tourdias' 'Vincent Planche' 'Rémi Giraud' 'Denis Rivière' 'Jean‐François Mangin' 'Nicole Labra-Avila' 'Roberto Vivo-Hernando' 'Gregorio Rubio' 'Fernando Aparici' 'María de la Iglesia-Vayá' 'Pierrick Coupé'] Jose V. Manj ´ on´…
Fernando Silva de Moura, Roberto G. Beraldo, Leonardo A. Ferreira, Samuli Siltanen
'Samuli Siltanen'] Volume conductor problems in cerebral electrophysiology and bioimpedance do not have analytical solutions for nontrivial geometries and require a 3D model of the head and its electrical properties for solving the associated PDEs numerically. Ideally, the model should be made with patient-specific…
Enahoro S. Abhulimen
The Human Genome Project changed everything. The 13-year-long campaign to create a reference human genome finally ended with the announcement of an essentially complete draft of the sequence in 2003. Advances in DNA sequencing technology, such as the development of automated Sanger sequencing machines like the ABI…
Human Cell Atlas Meeting Participants, Aviv Regev, Sarah A. Teichmann, Orit Rozenblatt–Rosen + 47 more
- Nervous system Ed Lein, Arnold Kriegstein, Paola Arlotta, and Sten Linnarsson - Immune system Christophe Benoist, Lars Fugger, Nir Hacohen, and Miriam Merad - Urinary: Kidney Menna Clatworthy and Anna Greka - Respiratory: Lung Jayaraj Rajagopal, Herbert Schiller, and Martijn Nawijn - Hepatopancreatic-biliary: Liver…
Jiawen Yang, Sen-Fang Sui, Zheng Liu
The brain is one of the most complex organs in nature. In this organ, multiple neurons, neuron clusters, or multiple brain regions are interconnected to form a complex structural network where various brain functions are completed through interaction. In recent years, multiple tools and techniques have been developed…
Yuncong Chen, Lauren E. McElvain, Alex Tolpygo, Daniel D. Ferrante + 4 more
'Harvey J. Karten' 'Partha P. Mitra' 'David Kleinfeld' 'Yoav Freund'] Abstract. While modern imaging technologies such as fMRI have opened exciting possibilities for studying the brain in vivo, histological sections remain the best way to study brain anatomy at the level of neurons. The procedure for building…
Ho Hin Lee, Adam Saunders, Michael E. Kim, Samuel W. Remedios + 13 more
'Yucheng Tang' 'Qi Yang' 'Xin Yu' 'Shunxing Bao' 'Chloe Cho' 'Louise A. Mawn' 'Tonia S. Rex' 'Kevin L. Schey' 'Blake E. Dewey' 'Jeffrey M. Spraggins' 'Jerry L. Prince' 'Yuankai Huo' 'Bennett A. Landman'] **Ho Hin Lee, a,† Adam M. Saunders, b,†, Michael E. Kim, a Samuel W. Remedios, c Lucas W. Remedios,a Yucheng Tang, b…
Virginia Gewin
The Allen Brain Atlas of gene expression in the mouse brain is poised to serve as an outstanding resource to neuroscience
Authors not listed
One aim of the international Human Proteome Organization (HUPO) Human Proteome Project (HPP) is to obtain high-confidence translation evidence for every human protein-coding gene established in its target list of 19433 entries based on the protein-coding genes from Ensembl-GENCODE. However, 76 are annotated in…
Aviv Regev, Sarah A. Teichmann, Eric S. Lander, Ido Amit + 54 more
The recent advent of methods for high-throughput single-cell molecular profiling has catalyzed a growing sense in the scientific community that the time is ripe to complete the 150-year-old effort to identify all cell types in the human body, by undertaking a Human Cell Atlas Project as an international collaborative…