20 papers · ranked by Valyu relevance
María del Carmen Pérez-Fuentes, Iván Herera-Peco, María del Mar Molero Jurado, Nieves Fátima Oropesa Ruiz + 2 more
'María del Mar Molero Jurado' 'Nieves Fátima Oropesa Ruiz' 'Diego Ayuso-Murillo' 'José Jesús Gázquez Linares'] Introduction: The approach and use of the term “humanization” is very much present in healthcare. However, instruments for measuring the concept of the humanization of care are yet to be designed and…
Nicolas Spatola, Serena Marchesi, Agnieszka Wykowska
Anthropomorphism describes the tendency to ascribe human characteristics to nonhuman agents. Due to the increased interest in social robotics, anthropomorphism has become a core concept of human-robot interaction (HRI) studies. However, the wide use of this concept resulted in an interchangeability of its definition.…
David Prihoda, Jad Maamary, Andrew Waight, Veronica Juan + 3 more
Despite recent advances in transgenic animal models and display technologies, humanization of mouse sequences remains the primary route for therapeutic antibody development. Traditionally, humanization is manual, laborious, and requires expert knowledge. Although automation efforts are advancing, existing methods are…
Zhe Sang, Yufei Xiang, Ivet Bahar, Yi Shi
Nanobodies (Nbs) have recently emerged as a promising class of antibody fragments for biomedical and therapeutic applications. Despite having marked physicochemical properties, Nbs are derived from camelids and may require “humanization” to improve translational potentials for clinical trials. Here we have…
Cade Gordon, Aniruddh Raghu, Heather Elliott, Peyton Greenside
Antibody therapies have been employed to address some of today's most challenging diseases, but must meet many criteria during drug development before reaching a patient. Humanization is a sequence optimization strategy that addresses one critical risk called immunogenicity — a patient's immune response to the drug —…
Mark Chin, Claire Marks, Charlotte M. Deane
Monoclonal antibody therapeutics are often produced from non-human sources (typically murine), and can therefore generate immunogenic responses in humans. Humanization procedures aim to produce antibody therapeutics that do not elicit an immune response and are safe for human use, without impacting efficacy.…
Ariel Tennenhouse, Lev Khmelnitsky, Noa Yeshaya, Ashish Noronha + 9 more
Humanization is an essential step in developing animal-derived antibodies into therapeutics, and approximately 40% of FDA-approved antibodies have been humanized. Conventional humanization approaches graft the complementarity-determining regions (CDRs) of the animal antibody onto several homologous human frameworks.…
Thomas Davies, Kumar Yogeeswaran, Maykel Verkuyten, Steve Loughnan + 1 more
'Valerio Capraro'] Dehumanization and infrahumanization involve decreasing the humanity attributed to others. Despite the existence of a large body of work on these topics, little is known about how to increase outgroup humanization. Across two experiments, we examined the effects of intergroup and intragroup helping…
Ángeles Reyes-Téllez, Alberto González-García, Adelina Martín-Salvador, María Gázquez-López + 2 more
'Adelina Martín-Salvador' 'María Gázquez-López' 'Encarnación Martínez-García' 'Inmaculada García-García'] Advances in healthcare in recent years have resulted in the automation and standardization of healthcare. Consequently, care has become dehumanized. There is a lack of trust from patients toward the health care…
Honggang Zou, Rongqing Yuan, Boqiao Lai, Yang Dou + 2 more
Antibody (Ab), also known as immunoglobulin (Ig), is an essential macromolecule involved in human immune response and plays an increasingly vital role in drug discovery. However, the development of antibody drugs heavily relies on humanization of murine antibodies, which often necessitates multiple rounds of sequence…
Qiang Zhong
Humanization of non-human derived antibody is necessary to reduce the immunogenicity of antibody drug. In recent years, computer aided antibody humanization became an efficient and rapid routine process. We report here a new computational humanization pipeline which includes CDR grafting onto the crystal structures of…
Dora Capozza, Gian Antonio Di Bernardo, Rossella Falvo, Alessandro Antonietti
'Alessandro Antonietti'] The attribution of uniquely human characteristics to the outgroup may favor the search for contact with outgroup members and, vice versa, contact experiences may improve humanity attributions to the outgroup. To explore this bidirectional relationship, two studies were performed. In Study 1…
Jaime Banks, Nicholas David Bowman, Roman Saladino
Anthropomorphic language describing artificial intelligence (AI) is widespread in media, policy, and everyday discourse; so too are discussions of AI bad behavior, from hallucinations to inappropriate comments. How does humanizing language about AI shape moral judgments when AI behaves badly? Across four experiments…
Gavin Abercrombie, Amanda Cercas Curry, Tanvi Dinkar, Verena Rieser + 1 more
'Zeerak Talat'] Automated dialogue or conversational systems are anthropomorphised by developers and personified by users. While a degree of anthropomorphism may be inevitable due to the choice of medium, conscious and unconscious design choices can guide users to personify such systems to varying degrees. Encouraging…
Anna Szuster, Agnieszka Wojnarowska
The paper investigates the role of mimicry in the reduction of infra-humanization. Mimicry as an automatic imitation of a partner’s behavior (this is known as “social glue”) connects people ([27]). Empirical findings have confirmed that mimicry leads to favorable treatment of the mimicker ([40]). The mechanism is…
Alicia DeVrio, Myra Cheng, Lisa Egede, Alexandra Olteanu + 1 more
'Su Lin Blodgett'] Recent attention to anthropomorphism—the attribution of humanlike qualities to non-human objects or entities—of language technologies like LLMs has sparked renewed discussions about potential negative impacts of anthropomorphism. To productively discuss the impacts of this anthropomorphism and in…
Holger Klapperich, Alarith Uhde, Marc Hassenzahl
Nowadays, automation not only dominates industry but becomes more and more a part of our private, everyday lives. Following the notion of increased convenience and more time for the "important things in life", automation relieves us from many daily household chores – robots vacuum floors and automated coffeemakers…
Cláudio Pinhanez
We use the term borg to refer to the complex organizations composed of people, machines, and processes with which users frequently interact using computer interfaces and websites. Unlike interfaces to pure machines, we contend that borg-human interaction (BHI) happens in a context combining the anthropomorphization of…
Iiris Sundin, Alexey Voronov, Haoping Xiao, Kostas Papadopoulos + 5 more
A de novo molecular design workflow can be used together with technologies such as reinforcement learning to navigate the chemical space. A bottleneck in the workflow that remains to be solved is how to integrate human feedback in the exploration of the chemical space to optimize molecules. A human drug designer still…
Tim Gorichanaz
Humanity-centered design is a concept of emerging interest in HCI, one motivated by the limitations of human-centered design. As discussed to date, humanity-centered design is compatible with but goes beyond human-centered design in that it considers entire ecosystems and populations over the long term and centers…