19 papers · ranked by Valyu relevance
Augusto Mellado, Eric Tapia Escobar, Sebastián Pavlovic, Marcela Riveros + 1 more
Introduction This umbrella review identified systematic and non-systematic reviews of quantitative and qualitative empirical studies on interventions aimed at promoting humanization in Primary Health Care (PHC). The objective of this umbrella review was to synthesize and compare the available evidence on interventions…
Nicolas Spatola, Serena Marchesi, Agnieszka Wykowska
Anthropomorphism describes the tendency to ascribe human characteristics to nonhuman agents. Due to the increased interest in social robotics, anthropomorphism has become a core concept of human-robot interaction (HRI) studies. However, the wide use of this concept resulted in an interchangeability of its definition.…
Cade Gordon, Aniruddh Raghu, Heather Elliott, Peyton Greenside
Antibody therapies have been employed to address some of today's most challenging diseases, but must meet many criteria during drug development before reaching a patient. Humanization is a sequence optimization strategy that addresses one critical risk called immunogenicity — a patient's immune response to the drug —…
Ariel Tennenhouse, Lev Khmelnitsky, Noa Yeshaya, Ashish Noronha + 9 more
Humanization is an essential step in developing animal-derived antibodies into therapeutics, and approximately 40% of FDA-approved antibodies have been humanized. Conventional humanization approaches graft the complementarity-determining regions (CDRs) of the animal antibody onto several homologous human frameworks.…
Jian Ma, Fandi Wu, Tingyang Xu, Shaoyong Xu + 4 more
Humanization is a critical process for designing efficiently specific antibodies and nanobodies prior to clinical trials. Developing widely recognized deep learning techniques or frameworks for humanizing conventional antibodies and nanobodies presents a valuable yet challenging task. Inspired by the effectiveness of…
Gemma L. Gordon, Matthew I. J. Raybould, Ashley Wong, Charlotte M. Deane
'Charlotte M. Deane'] To be viable therapeutics, antibodies must be tolerated by the human immune system. Rational approaches to reduce the risk of unwanted immunogenicity involve maximizing the ‘humanness’ of the candidate drug. However, despite the emergence of new discovery technologies, many of which start from…
Ángeles Reyes-Téllez, Alberto González-García, Adelina Martín-Salvador, María Gázquez-López + 2 more
'Adelina Martín-Salvador' 'María Gázquez-López' 'Encarnación Martínez-García' 'Inmaculada García-García'] Advances in healthcare in recent years have resulted in the automation and standardization of healthcare. Consequently, care has become dehumanized. There is a lack of trust from patients toward the health care…
Haiying Wang, Chunqiu Xia, Yupeng Zhu, Yali Wang + 8 more
Antibody humanization is an essential part of converting animal-derived antibodies into clinical candidates however conventional CDR grafting techniques often faces challenges, especially when essential antigen-binding sites extend beyond CDR regions. Additionally, the CDR grafting process tends to retain undesired…
Honggang Zou, Rongqing Yuan, Boqiao Lai, Yang Dou + 2 more
Antibody (Ab), also known as immunoglobulin (Ig), is an essential macromolecule involved in human immune response and plays an increasingly vital role in drug discovery. However, the development of antibody drugs heavily relies on humanization of murine antibodies, which often necessitates multiple rounds of sequence…
Denis E. Matytsin, Valentin A. Dzedik, Galina A. Markeeva, Saglar B. Boldyreva
'Saglar B. Boldyreva'] The article focuses on the problem of optimizing human resource management with systematic coverage of economic efficiency and corporate social responsibility. The purpose of the article is to study the role of outsourcing in the humanization of entrepreneurship in the AI economy. The potential…
Jaime Banks, Nicholas David Bowman, Roman Saladino
Anthropomorphic language describing artificial intelligence (AI) is widespread in media, policy, and everyday discourse; so too are discussions of AI bad behavior, from hallucinations to inappropriate comments. How does humanizing language about AI shape moral judgments when AI behaves badly? Across four experiments…
Islam Borinca, Sofia Stathi, Theofilos Gkinopoulos
People in post-conflict settings often carry traumatic memories that exacerbate dehumanization and obstruct reconciliation. We investigated these processes through three studies in postwar Kosovo. Study 1 (N = 200), correlational, found that disturbing war-related memories negatively predicted openness to contact and…
Gavin Abercrombie, Amanda Cercas Curry, Tanvi Dinkar, Verena Rieser + 1 more
'Zeerak Talat'] Automated dialogue or conversational systems are anthropomorphised by developers and personified by users. While a degree of anthropomorphism may be inevitable due to the choice of medium, conscious and unconscious design choices can guide users to personify such systems to varying degrees. Encouraging…
Alicia DeVrio, Myra Cheng, Lisa Egede, Alexandra Olteanu + 1 more
'Su Lin Blodgett'] Recent attention to anthropomorphism—the attribution of humanlike qualities to non-human objects or entities—of language technologies like LLMs has sparked renewed discussions about potential negative impacts of anthropomorphism. To productively discuss the impacts of this anthropomorphism and in…
Mark Díaz, Renee Shelby, Eric Corbett, Andrew Smart
Generative AI's humanlike qualities are driving its rapid adoption in professional domains. However, this anthropomorphic appeal raises concerns from HCI and responsible AI scholars about potential hazards and harms, such as overtrust in system outputs. To investigate how technology workers navigate these humanlike…
Laura E. Jastrzab, Bishakha Chaudhury, Sarah A. Ashley, Kami Koldewyn + 1 more
We sought to replicate and expand previous work showing that the more human-like a robot appears, the more willing people are to attribute mind-like capabilities and socially engage with it. Forty-two participants played games against a human, a humanoid robot, a mechanoid robot, and a computer algorithm while…
Aikaterina Manoli, Janet V. T. Pauketat, Jacy Reese Anthis
Robots and other artificial intelligence (AI) systems are widely perceived as moral agents responsible for their actions. As AI proliferates, these perceptions may become entangled via the moral spillover of attitudes towards one AI to attitudes towards other AIs. We tested how the seemingly harmful and immoral actions…
Iiris Sundin, Alexey Voronov, Haoping Xiao, Kostas Papadopoulos + 5 more
A de novo molecular design workflow can be used together with technologies such as reinforcement learning to navigate the chemical space. A bottleneck in the workflow that remains to be solved is how to integrate human feedback in the exploration of the chemical space to optimize molecules. A human drug designer still…
Tim Gorichanaz
Humanity-centered design is a concept of emerging interest in HCI, one motivated by the limitations of human-centered design. As discussed to date, humanity-centered design is compatible with but goes beyond human-centered design in that it considers entire ecosystems and populations over the long term and centers…