28 papers · ranked by Valyu relevance
David M. Morens, Anthony S. Fauci, Joseph Heitman
The inevitable, but unpredictable, appearance of new infectious diseases has been recognized for millennia, well before the discovery of causative infectious agents. Today, however, despite extraordinary advances in development of countermeasures (diagnostics, therapeutics, and vaccines), the ease of world travel and…
Nicholas Israel Nii-Trebi
Infectious diseases are a significant burden on public health and economic stability of societies all over the world. They have for centuries been among the leading causes of death and disability and presented growing challenges to health security and human progress. The threat posed by infectious diseases is further…
Joel Henrique Ellwanger, Ana Beatriz Gorini da Veiga, Valéria de Lima Kaminski, Jacqueline María Valverde-Villegas + 2 more
'Valéria de Lima Kaminski' 'Jacqueline María Valverde-Villegas' 'Abner Willian Quintino de Freitas' 'José Artur Bogo Chies'] Title: Abstract The ongoing COVID-19 pandemic has caught the attention of the global community and rekindled the debate about our ability to prevent and manage outbreaks, epidemics, and…
Jos W. M. van der Meer
Infectious diseases form one of the greatest global challenges in medicine in our time. Ever since the famous, wrong prediction of the Surgeon General of the United States, William H. Stewart, in 1969: “We can close the books on infectious diseases,” infectious diseases have been on the rise. A large number of new…
Wen-Hung Wang, Arunee Thitithanyanont, Aspiro Nayim Urbina, Sheng-Fan Wang
Throughout history, infectious diseases have vastly impacted human civilization. Around fifty years ago, many people believed that the age-old battle of humans against infectious disease was virtually over and that humankind were the winners . Unfortunately, several new diseases emerged during the past decades (such as…
Mohammad Ali Jahani, Zohreh Alinasab, Maysam Rezapour, Melodi Omrani Nava + 1 more
'Melodi Omrani Nava' 'Ghahraman Mahmoudi'] Background: Despite the development of their prevention and treatment, infectious diseases cause high mortality, many disabilities and inadequate living conditions worldwide. The aim of this study was to evaluate the pattern of infectious diseases in northern Iran with an…
Shahzamal, Saeed Khan
Infectious diseases are a significant threat to human society which was over sighted before the incidence of COVID-19, although according to the report of the World Health Organisation (WHO) about 4.2 million people die annually due to infectious disease. Due to recent COVID-19 pandemic, more than 2 million people died…
Arthur Vengesai, Maritha Kasambala, Hamlet Mutandadzi, Tariro L. Mduluza-Jokonya + 2 more
This scoping review explores the use of peptide microarrays in the fight against infectious diseases. The research domains explored included the use of peptide microarrays in the mapping of linear B-cell and T cell epitopes, antimicrobial peptide discovery, immunosignature characterisation and disease…
P. Raja Sekhara Rao, M. Naresh Kumar
Understanding dynamics of an infectious disease helps in designing appropriate strategies for containing its spread in a population. Recent mathematical models are aimed at studying dynamics of some specific types of infectious diseases. In this paper we propose a new model for infectious diseases spread having…
Min Yue, Huanchun Chen
| 3 | Min Yue 1, 2, *, Huanchun Chen3, 4 | | | | | | | | --- | --- | --- | --- | --- | --- | --- | --- | | 4 | 1 2 The Institute for Translational Medicine and Therapeutics; Department of | | | | | | | | 5 | Pathobiology School | of | Veterinary | Medicine, | University | of | Pennsylvania, | | 6 | Philadelphia, PA…
Ellen E. Brandell, Daniel J. Becker, Laura Sampson, Kristian M. Forbes
Micro- and macroparasites are a leading cause of mortality for humans, animals, and plants, and there is great need to understand their origins, transmission dynamics, and impacts. Disease ecology formed as an interdisciplinary field in the 1970s to fill this need and has recently rapidly grown in size and influence.…
T Poisot, C Nunn, S Morand
Infectious diseases are a major burden on human population, especially in low- and middle-income countries. The increase in the rate of emergence of infectious outbreaks necessitates a better understanding of the worldwide distribution of diseases through space and time. We analyze 100 years of records of diseases…
Wenliang Wang, Manoj Hariharan, Anna Bartlett, Cesar Barragan + 39 more
Variations in DNA methylation patterns in human tissues have been linked to various environmental exposures and infections. Here, we identified the DNA methylation signatures associated with multiple exposures in nine major immune cell types derived from peripheral blood mononuclear cells (PBMCs) at single-cell…
Seyid, Moksina, Seid, Abdu Mohammed + 2 more
Tuberculosis (TB) continues to pose a major public health challenge, particularly in high-burden regions such as Ethiopia, necessitating a more profound understanding of its transmission dynamics. In this study, we developed an SVEITRS compartmental model to investigate the transmission dynamics of TBs, utilizing real…
Maciej Henneberg, Kara Holloway-Kew, Teghan Lucas
The key to evolution is reproduction. Pathogens can either kill the human host or can invade the host without causing death, thus ensuring their own survival, reproduction and spread. Tuberculosis, treponematoses and leprosy are widespread chronic infectious diseases whereby the host is not immediately killed. These…
Samantha Sambado, Sadie J Ryan
Public health resources are often allocated based on reported disease cases. However, for lesser-known infectious diseases, such as tick-borne viruses, disease risk reporting should account for more than just the biology of the disease and include mediating factors such as socioeconomics which can determine if an…
Carlos Óscar S. Sorzano
This article explores mathematical models for understanding the evolution of contagious diseases. The most widely known set of models are the compartmental ones, which are based on a set of differential equations. But these are not the only models. This review visits many different families of models: deterministic…
Van Kinh Nguyen, Cesar Parra-Rojas, Esteban A. Hernandez-Vargas
Since August 1, 2017, Madagascar has endured an outbreak of plague. A total of 2119 cases of plague has been confirmed, causing until now a death toll of 195. Public health interventions have been introduced, preventing new cases and deaths. However, it is likely that the outbreak could reappear as plague is endemic in…
Lai-Sang Young, Stefan Ruschel, Serhiy Yanchuk, Tiago Pereira
For centuries isolation has been the main control strategy of unforeseen epidemic outbreaks. When implemented in full and without delay, isolation is very effective. However, flawless implementation is seldom feasible in practice. We present an epidemic model called SIQ with an isolation protocol, focusing on the…
Shane Babcock, Carter Benson, Giacomo De Colle, Sidney Cohen + 5 more
'Alexander D. Diehl' 'Ram A. N. R. Challa' 'Anthony Huffman' 'Yongqun He' 'John Beverley'] Background: Infectious diseases remain a critical global health challenge, and the integration of standardized ontologies plays a vital role in managing related data. The Infectious Disease Ontology (IDO) and its extensions, such…
wenzhong liu, hualan li
Ebola sickness is a hemorrhagic fever caused by the Ebola virus that has an extremely high fatality rate. Electrolyte imbalance is a typical sign in Ebola patients who have already contracted the virus. The use of bioinformatics calculation tools to research Ebola's electrolyte imbalance mechanism is critical for…
Zicong Zhang, Lixun Zhu, Ziwei Deng, Jialin Zeng + 4 more
Microbial pathogens, including bacteria, fungi, and viruses, greatly threaten the global public health. For pathogen infections, early diagnosis and precise treatment are essential to cut the mortality rate. The emergence of aggregationinduced emission (AIE) biomaterials provides an effective and promising tool for the…
Authors not listed
Methicillin-resistant Staphylococcus aureus (MRSA) is one of a leading cause of antibiotic-resistant bacterial infections. Based on our previous findings, we utilized thiazole-fused nootkatone hit compounds to develop a simple phenol-substituted thiazole scaffold as potent antibacterial agents, particularly active…
Dylan Smith, Kristin Lauro, Dymond Kelly, Joel Fish + 6 more
A physical chemistry lab for undergraduate students described in this report is about applying kinetic models to analyze the spread of COVID-19 in the United States and obtain the reproduction numbers. The susceptible-infectious-recovery (SIR) model and the SIR-vaccinated (SIRV) model are explained to the students and…
Angelo Frei, Alysha G. Elliott, Alex Kan, Hue Dinh + 24 more
There are currently fewer than ten antifungal drugs in clinical development, but new fungal strains, which are resistant to most current antifungals are spreading rapidly across the world. To prevent a second resistance crisis, new classes of antifungal drugs are urgently needed. Metal complexes have proven to be…
Authors not listed
The global rise of antimicrobial resistance necessitates the search for novel therapeutic agents from natural sources, particularly medicinal plants. Stereospermum kunthianum (Pink Jacaranda) has long been employed in traditional medicine for the treatment of infectious diseases; however, its antibacterial efficacy…
Gregson, Watson, Orton, Haddrell + 9 more
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has resulted in an unprecedented shutdown in social and economic activity with the cultural sector particularly severely affected. Restrictions on performance have arisen from a perception that there is a significantly higher risk of aerosol…
Rahul Sharma, Amit Patel
Salivary diagnostics offers a promising method for early diagnosis, prognosis, and post-therapy monitoring. Saliva contains various hormones, proteins, enzymes, antibodies, antimicrobial constituents, and cytokines that can provide diagnostic information. Saliva is easy to collect, non- invasive, cost-effective, and…