28 papers · ranked by Valyu relevance
Linlin Chen, Huidan Deng, Hengmin Cui, Jing Fang + 5 more
'Junliang Deng' 'Yinglun Li' 'Xun Wang' 'Ling Zhao'] Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas, liver…
Neville A Punchard, Cliff J Whelan, Ian Adcock
Welcome to the Journal of Inflammation, the first open-access, peer-reviewed, online journal to focus on all aspects of the study of inflammation and inflammatory conditions. While research into inflammation has resulted in great progress in the latter half of the 20th century, the rate of progress is rapidly…
Kalpesh R. Patil, Umesh B. Mahajan, Banappa S. Unger, Sameer N. Goyal + 4 more
'Sameer N. Goyal' 'Sateesh Belemkar' 'Sanjay J. Surana' 'Shreesh Ojha' 'Chandragouda R. Patil'] Inflammation is one of the common events in the majority of acute as well as chronic debilitating diseases and represent a chief cause of morbidity in today’s era of modern lifestyle. If unchecked, inflammation leads to…
Bryan Oronsky, Scott Caroen, Tony Reid, Antonio Gomez-Muñoz
In medicine, inflammation is a fuzzy, overused word first coined by the Romans, the intended meaning and precise definition of which varies according to the person and the clinical context. It tends to carry a negative connotation as a response gone awry, like a raging, out-of-control wildfire that requires immediate…
Elisa A. Liehn, Hector A. Cabrera-Fuentes
Inflammation represents a complex biological response to harmful stimuli. The word comes from the latin “inflammatio”, literally meaning burning or setting on fire-, being mostly considered a negative response of the organism to the infection (pain, heat, redness, swelling and loss of function). However, we are now…
Chunxu Luo, Lin Zou, Huijun Sun, Jinyong Peng + 5 more
'Liuchi Bao' 'Renpeng Ji' 'Yue Jin' 'Shuangyong Sun'] Inflammatory diseases are caused by abnormal immune responses and are characterized by an imbalance of inflammatory mediators and cells. In recent years, the anti-inflammatory activity of natural products has attracted wide attention. Rosmarinic acid (RosA) is a…
Md. Asad Ullah, Fatema Tuz Johora, Bishajit Sarkar, Yusha Araf + 1 more
In this study Curcumin and their different analogues have been analyzed as the inhibitors of signaling proteins i.e., Cycloxygenase-2 (COX-2), Inhibitor of Kappaβ Kinase (IKK) and TANK binding kinase-1 (TBK-1) of Toll Like Receptor 4 (TLR4) pathway involved in inflammation using computational tools. Multiple analogues…
Sandra Pohl, Tobias Akamp, Martyna Smeda, Stefan Uderhardt + 5 more
'David Besold' 'Gabriel Krastl' 'Kerstin M. Galler' 'Wolfgang Buchalla' 'Matthias Widbiller'] The pulp is a unique tissue within each tooth that is susceptible to painful inflammation, known as pulpitis, triggered by microbial invasion from carious lesions or trauma that affect many individuals. The host response…
Kero Jemal
Allophylus serratus is a medicinal plant used traditionally as anti-inflammatory agent. The main objectives of this study are to identify phytochemical compounds that have anti-inflammatory properties from the leaf extracts of Allophylus serratus and to search for cyclooxygenase-2 (COX-2) enzyme inhibitors through…
Daniel Kalb, Huy D. Vo, Samantha Adikari, Elizabeth Hong-Geller + 2 more
IL-1β and TNFα are canonical immune response mediators that play key regulatory roles in a wide range of inflammatory responses to both chronic and acute conditions. Here we employ an automated microscopy platform for the analysis of messenger RNA (mRNA) expression of IL-1β and TNFα at the single-cell level. The amount…
Young-Su Yi, Han Gyung Kim, Ji Hye Kim, Woo Seok Yang + 7 more
Inflammation, a vital immune response to infection and injury, is mediated by macrophage activation. Spleen tyrosine kinase (Syk) and myeloid differentiation primary response 88 (MyD88) regulate the inflammatory response in macrophages, however, their roles and the underlying mechanisms are still largely unknown. In…
Mohamed Hamed, Esmail Abdelmonem, Mahmoud Zayed, Sameh Shaban + 2 more
Recently, there has been increasing evidence on the use of macrolide antibiotics in treatment of chronic inflammatory diseases through mechanisms distinct from their antibacterial activity. The key desired effect lies somewhere between these two therapeutic potentials and has not been identified yet. The aim of the…
Li Han, Xinran Wu, Ou Wang, William H. Velander + 6 more
Many reasons, such as infection, injury, tissue transplantation, and cancer treatment, can cause dysregulated hyperinflammation. Immune cells become excessive and hyperactive, producing sustained, systemic and large quantities of cytokines. The systemic inflammation can rapidly progress to disseminated intravascular…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Evangelina Costantino, Sofía Daiana Castell, María Florencia Harman, María Cristina Pistoresi- Palencia + 1 more
to analyze salivary concentrations interleukin-1β (IL-1β), 6 (IL-6) and tumor necrosis factor (TNF) according to age in healthy subjects to determine baseline inflammatory state of the oral mucosa in elderly subjects, who are at higher risk of developing inflammation-related diseases. sixty-four healthy volunteers were…
Kristen A. Windoloski, Elisabeth O. Bansgaard, A Dobréva, Johnny T. Ottesen + 1 more
'Johnny T. Ottesen' 'Mette S. Olufsen'] Abstract This study develops a unified model predicting the whole-body response to endotoxin. We simulate dynamics using differential equations examining the response to a lipopolysaccharide (LPS) injection. The model tracks pro- and antiinflammatory cytokines (TNF-, IL-6…
Sobia Anjum, Tazeem Akram, Unnatti Sharma, Omesh Manhas + 3 more
Inflammation serves as a vital physiological process essential for preserving health and countering illness. Yet, persistent inflammation drives osteoclastogenesis and ongoing bone erosion in rheumatoid arthritis (RA), mainly via macrophage activation and overproduction of pro-inflammatory cytokines like TNF-α, IL-1β…
A Dobréva, Renee Brady‐Nicholls, Kamila Larripa, Charles Puelz + 2 more
'Jesper Mehlsen' 'Mette S. Olufsen'] Uncontrolled, excessive production of pro-inflammatory mediators from immune cells and traumatized tissues can cause systemic inflammatory issues like sepsis, one of the ten leading causes of death in the United States and one of the three leading causes of death in the intensive…
Authors not listed
Type 2 inflammation is an essential defense mechanism of the innate and adaptive immune systems, but when dysregulated, it can cause chronic atopic diseases like allergic asthma and atopic dermatitis. Thymic stromal lymphoprotein (TSLP) helps drive type 2 inflammation by guiding T cells toward a type 2 helper cell…
C. Hepburn, Alexis Jones, Alan Bainbridge, Coziana Ciurtin + 5 more
'Juan Eugenio Iglesias' 'Hui Zhang' 'Margaret Hall‐Craggs' 'Timothy Bray' 'Joint senior authorship.'] Carolyna Hepburn1,2 PhD Alexis Jones1,3 MBBChir MD(Res) Alan Bainbridge4 PhD Coziana Ciurtin3 MBBS PhD Juan Eugenio Iglesias2,5,6 PhD Hui Zhang3 PhD Margaret A. Hall-Craggs1,7 MBBChir MD(Res) Timothy JP Bray1,2,7…
Ouassim Bara, Michel Fliess, Cédric Join, Judy Day + 1 more
'Seddik M. Djouadi'] Abstract— Control of an inflammatory immune response is still an ongoing research. Here, a strategy consisting of manipulating a pro and anti-inflammatory mediator is considered. Already existing and promising model-based techniques suffer unfortunately from a most difficult calibration. This is…
Authors not listed
The human immune system is central in the defense against pathogens but is also involved in autoimmune diseases. Inflammatory processes are orchestrated by biomolecules, including the inflammation marker C-reactive protein (CRP), for which fast point-of-care diagnostics is desired. Single-walled carbon nanotubes…
Grégoire Nadin, Éric Ogier‐Denis, Ana Isis Toledo Marrero, Hatem Zaag
'Hatem Zaag'] Abstract Crohns disease is an inflammatory bowel disease (IBD) that is not well understood. In particular, unlike other IBDs, the inflamed parts of the intestine compromise deep layers of the tissue and are not continuous but separated and distributed through the whole gastrointestinal tract, displaying a…
Eric W. Jones, Jiming Sheng, Jean M. Carlson, Shenshen Wang
The adaptive and innate branches of the vertebrate immune system work in close collaboration to protect organisms from harmful pathogens. As an organism ages its immune system undergoes immunosenescence, characterized by declined performance or malfunction in either immune branch, which can lead to disease and death.…
Rick Sheridan, Kevin Spelman
The Covid-19 pandemic has elicited much laboratory and clinical research attention on vaccines, mAbs, and certain small-molecule antivirals against SARS-CoV-2 infection. By contrast, there has been comparatively little attention on plant-derived compounds, especially those that are understood to be safely ingested at…
Authors not listed
A steep, age‑related drop in nicotinamide adenine dinucleotide (NAD+) now ranks among the most reproducible molecular signatures of human aging, driving metabolic slowdown, mitochondrial dysfunction, DNA‑repair deficits, chronic inflammation, and stem‑cell fatigue. Boost NAD+ for Anti‑Aging: A Multidimensional Review…
Authors not listed
The design and development of Curcumin nanoparticles has attracted and established torrential research in nano formulation matrix. By appearance Curcumin is an orange crystalline powder which is derived or obtained from the herbs Curcumin Longa Linn (Zingiberaceae). The Curcumin is natural hydrophobic polyphenol…
Kazeem Olanrewaju, Ashlee N. Ford Versypt
The human physiological system consists of several biological units carefully organized to engage in a bio-physicochemical interaction with complex fluids transporting nutritional and life-supporting species (oxygen and carbon dioxide) needed for the proper functioning of the body. The nutritional species are products…