26 papers · ranked by Valyu relevance
Anna L. Kiss
The inflammation is an important biological response induced by various harmful stimuli, like viruses, bacterial infections, toxins, toxic compounds, tissue injury. During inflammation inflammatory cytokines and reactive oxygen species are produced. Inflammatory cytokines act on various receptors present on the plasma…
Bryan Oronsky, Scott Caroen, Tony Reid, Antonio Gomez-Muñoz
In medicine, inflammation is a fuzzy, overused word first coined by the Romans, the intended meaning and precise definition of which varies according to the person and the clinical context. It tends to carry a negative connotation as a response gone awry, like a raging, out-of-control wildfire that requires immediate…
Laura Jiménez-Gracia, Davide Maspero, Sergio Aguilar-Fernández, Francesco Craighero + 42 more
Inflammation is a biological phenomenon involved in a wide variety of physiological and pathological processes. Although a controlled inflammatory response is beneficial for restoring homeostasis, it can become unfavorable if dysregulated. In recent years, major progress has been made in characterizing acute and…
Akib Nisar, Suresh Jagtap, Suresh Vyavahare, Manasi Deshpande + 3 more
'Abhay Harsulkar' 'Prabhakar Ranjekar' 'Om Prakash'] Advances in biomedical research have demonstrated that inflammation and its related diseases are the greatest threat to public health. Inflammatory action is the pathological response of the body towards the external stimuli such as infections, environmental factors…
Ysrafil Ysrafil, Zulfiayu Sapiun, Nangsih Sulastri Slamet, Fihrina Mohamad + 9 more
'Fihrina Mohamad' 'Hartati Hartati' 'Sukmawati A Damiti' 'Francisca Diana Alexandra' 'Sudarman Rahman' 'Sri Masyeni' 'Harapan Harapan' 'Sukamto S. Mamada' 'Talha Bin Emran' 'Firzan Nainu'] Background and purpose Flavonoids are a group of phytochemicals found abundantly in various plants. Scientific evidence has…
Sandra Pohl, Tobias Akamp, Martyna Smeda, Stefan Uderhardt + 5 more
'David Besold' 'Gabriel Krastl' 'Kerstin M. Galler' 'Wolfgang Buchalla' 'Matthias Widbiller'] The pulp is a unique tissue within each tooth that is susceptible to painful inflammation, known as pulpitis, triggered by microbial invasion from carious lesions or trauma that affect many individuals. The host response…
Renhao Ni, Lingjing Jiang, Chaohai Zhang, Mujie Liu + 6 more
'Zeming Hu' 'Xianbo Mou' 'Yabin Zhu' 'Jacek Z. Kubiak' 'Malgorzata Kloc'] Pro-inflammatory and anti-inflammatory types are the main phenotypes of the macrophage, which are commonly notified as M1 and M2, respectively. The alteration of macrophage phenotypes and the progression of inflammation are intimately associated…
Kristen A. Windoloski, Elisabeth O. Bansgaard, A Dobréva, Johnny T. Ottesen + 1 more
'Johnny T. Ottesen' 'Mette S. Olufsen'] Abstract This study develops a unified model predicting the whole-body response to endotoxin. We simulate dynamics using differential equations examining the response to a lipopolysaccharide (LPS) injection. The model tracks pro- and antiinflammatory cytokines (TNF-, IL-6…
Evangelina Costantino, Sofía Daiana Castell, María Florencia Harman, María Cristina Pistoresi- Palencia + 1 more
to analyze salivary concentrations interleukin-1β (IL-1β), 6 (IL-6) and tumor necrosis factor (TNF) according to age in healthy subjects to determine baseline inflammatory state of the oral mucosa in elderly subjects, who are at higher risk of developing inflammation-related diseases. sixty-four healthy volunteers were…
Li Han, Xinran Wu, Ou Wang, William H. Velander + 6 more
Many reasons, such as infection, injury, tissue transplantation, and cancer treatment, can cause dysregulated hyperinflammation. Immune cells become excessive and hyperactive, producing sustained, systemic and large quantities of cytokines. The systemic inflammation can rapidly progress to disseminated intravascular…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Billie J. Matchett, Jack P. Green, Paula I. Seoane, Abigail Owen + 7 more
The NLRP3 inflammasome, an important multi-molecular protein complex driving inflammation, is activated by multiple cellular stresses, including a loss of organelle homeostasis. Studies indicate that lysosome disruption can play a role in NLRP3 inflammasome activation, but whether lysosome positioning impacts NLRP3…
Sobia Anjum, Tazeem Akram, Unnatti Sharma, Omesh Manhas + 3 more
Inflammation serves as a vital physiological process essential for preserving health and countering illness. Yet, persistent inflammation drives osteoclastogenesis and ongoing bone erosion in rheumatoid arthritis (RA), mainly via macrophage activation and overproduction of pro-inflammatory cytokines like TNF-α, IL-1β…
Nicola Andina, Louise de Meuron, Annatina Sarah Schnegg-Kaufmann, Camille Ansermet + 6 more
Aging causes chronic low-grade inflammation known as inflamm-aging. It is a risk factor for chronic myelomonocytic leukemia (CMML), a hematological malignancy that is most prevalent in older people. Recent studies suggest a critical role for the NLRP3 inflammasome in inflamm-aging. However, the mechanisms involved in…
Authors not listed
Type 2 inflammation is an essential defense mechanism of the innate and adaptive immune systems, but when dysregulated, it can cause chronic atopic diseases like allergic asthma and atopic dermatitis. Thymic stromal lymphoprotein (TSLP) helps drive type 2 inflammation by guiding T cells toward a type 2 helper cell…
Cordula Reisch, Sandra Nickel, Hans‐Michael Tautenhahn
The paper presents an approach for overcoming modeling problems of typical life science applications with partly unknown mechanisms and lacking quantitative data: A model family of reaction diffusion equations is built up on a mesoscopic scale and uses classes of feasible functions for reaction and taxis terms. The…
Austin Sovar, Matthew Patrick, Ramkumar T. Annamalai
Inflammation serves as a critical defense mechanism against pathogens and tissue damage but can lead to chronic diseases, such as cardiovascular disease and diabetes, when dysregulated. Macrophages play a pivotal role in orchestrating inflammatory responses, transitioning from pro-inflammatory M1 to anti-inflammatory…
Authors not listed
The human immune system is central in the defense against pathogens but is also involved in autoimmune diseases. Inflammatory processes are orchestrated by biomolecules, including the inflammation marker C-reactive protein (CRP), for which fast point-of-care diagnostics is desired. Single-walled carbon nanotubes…
Daria Poul, Amanda Rodriguez Betancourt, Ankita Samal, Carole Quesada + 5 more
In the USA, periodontal diseases, a spectrum of inflammatory conditions, affect 4 out of 10 adults (>=30 years). Current standards of care in clinical assessment of these diseases are invasive, subjective, only semi-quantitative, and primarily detecting later stages. Applications of ultrasonography in periodontology…
Rick Sheridan, Kevin Spelman
The Covid-19 pandemic has elicited much laboratory and clinical research attention on vaccines, mAbs, and certain small-molecule antivirals against SARS-CoV-2 infection. By contrast, there has been comparatively little attention on plant-derived compounds, especially those that are understood to be safely ingested at…
Himanshi Tanwar, Jeba Mercy Gnanasekaran, Devon L. Allison, Ling-Shiang Chuang + 11 more
'Ling-Shiang Chuang' 'Xuesong He' 'Mario Aimetti' 'Giacomo Baima' 'Massimo Costalonga' 'Raymond K. Cross' 'Cynthia L. Sears' 'Saurabh Mehandru' 'Judy H. Cho' 'Jean‐Frédéric Colombel' 'Jean‐Pierre Raufman' 'Vivek Thumbigere‐Math'] Periodontitis and Inflammatory Bowel Disease (IBD) are chronic inflammatory conditions…
David Liu
Resiniferatoxin is a diterpene found in E. resinifera and E. poissonii, and is a more potent functional analog of capsaicin. Resiniferatoxin provides pain relief by binding as an agonist to transient vanilloid receptor 1 (TRPV1), a nociceptive ion channel. Resiniferatoxin targets the TRPV1 channel and activates it…
Bailey-Feliciano, Bryan, VanVeckhoven, George + 6 more
Chronic critical illness (CCI) is a disease state in which, following an initial insult, a patient neither recovers nor dies but instead remains in a state of critical illness. CCI is characterized by prolonged organ dysfunction, weight loss, and persistent increased vulnerability to infection. Recent data has shown…
Jiqing Huang, Benjamin Leporq, Valérie Hervieu, Sophie Gaillard + 3 more
Chronic liver disease (CLD) is a leading cause of morbidity and mortality worldwide, accounting for an estimated two million deaths per year [1]. It includes a large variety of hepatic diseases that, in most subtypes, damage the liver in similar ways [2]. CLD progression may be characterized by histology with the…
Authors not listed
A steep, age‑related drop in nicotinamide adenine dinucleotide (NAD+) now ranks among the most reproducible molecular signatures of human aging, driving metabolic slowdown, mitochondrial dysfunction, DNA‑repair deficits, chronic inflammation, and stem‑cell fatigue. Boost NAD+ for Anti‑Aging: A Multidimensional Review…
Kazeem Olanrewaju, Ashlee N. Ford Versypt
The human physiological system consists of several biological units carefully organized to engage in a bio-physicochemical interaction with complex fluids transporting nutritional and life-supporting species (oxygen and carbon dioxide) needed for the proper functioning of the body. The nutritional species are products…