28 papers · ranked by Valyu relevance
Irene Maeve Rea, David S. Gibson, Victoria McGilligan, Susan E. McNerlan + 2 more
'Susan E. McNerlan' 'H. Denis Alexander' 'Owen A. Ross'] Cytokine dysregulation is believed to play a key role in the remodeling of the immune system at older age, with evidence pointing to an inability to fine-control systemic inflammation, which seems to be a marker of unsuccessful aging. This reshaping of cytokine…
Jeanette M. Bennett, Glenn Reeves, George E. Billman, Joachim P. Sturmberg
'Joachim P. Sturmberg'] Siloed or singular system approach to disease management is common practice, developing out of traditional medical school education. Textbooks of medicine describe a huge number of discrete diseases, usually in a systematic fashion following headings like etiology, pathology, investigations…
Kalpesh R. Patil, Umesh B. Mahajan, Banappa S. Unger, Sameer N. Goyal + 4 more
'Sameer N. Goyal' 'Sateesh Belemkar' 'Sanjay J. Surana' 'Shreesh Ojha' 'Chandragouda R. Patil'] Inflammation is one of the common events in the majority of acute as well as chronic debilitating diseases and represent a chief cause of morbidity in today’s era of modern lifestyle. If unchecked, inflammation leads to…
Renhao Ni, Lingjing Jiang, Chaohai Zhang, Mujie Liu + 6 more
'Zeming Hu' 'Xianbo Mou' 'Yabin Zhu' 'Jacek Z. Kubiak' 'Malgorzata Kloc'] Pro-inflammatory and anti-inflammatory types are the main phenotypes of the macrophage, which are commonly notified as M1 and M2, respectively. The alteration of macrophage phenotypes and the progression of inflammation are intimately associated…
Md. Asad Ullah, Fatema Tuz Johora, Bishajit Sarkar, Yusha Araf + 1 more
In this study Curcumin and their different analogues have been analyzed as the inhibitors of signaling proteins i.e., Cycloxygenase-2 (COX-2), Inhibitor of Kappaβ Kinase (IKK) and TANK binding kinase-1 (TBK-1) of Toll Like Receptor 4 (TLR4) pathway involved in inflammation using computational tools. Multiple analogues…
Young-Su Yi, Han Gyung Kim, Ji Hye Kim, Woo Seok Yang + 7 more
Inflammation, a vital immune response to infection and injury, is mediated by macrophage activation. Spleen tyrosine kinase (Syk) and myeloid differentiation primary response 88 (MyD88) regulate the inflammatory response in macrophages, however, their roles and the underlying mechanisms are still largely unknown. In…
Yan, Xianyi, Xi Wang, Ying Che + 2 more
- 1 Department of Orthopaedic, The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, 528200 Foshan,Guangdong, China; lyyanxy@scut.edu.cn(X.Y.);zhangtin@pitt.edu (T.Z.) - 2 Department of Trauma Orthopedics, The First Affiliated Hospital of Xinjiang Medical University, 830011 Urumqi…
Sobia Anjum, Tazeem Akram, Unnatti Sharma, Omesh Manhas + 3 more
Inflammation serves as a vital physiological process essential for preserving health and countering illness. Yet, persistent inflammation drives osteoclastogenesis and ongoing bone erosion in rheumatoid arthritis (RA), mainly via macrophage activation and overproduction of pro-inflammatory cytokines like TNF-α, IL-1β…
Jacek Hawiger, Jozef Zienkiewicz
Inflammation is the mechanism of diseases caused by microbial, autoimmune, allergic, metabolic and physical insults that produce distinct types of inflammatory responses. This aetiologic view of inflammation informs its classification based on a cause-dependent mechanism as well as a cause-directed therapy and…
Elisa A. Liehn, Hector A. Cabrera-Fuentes
Inflammation represents a complex biological response to harmful stimuli. The word comes from the latin “inflammatio”, literally meaning burning or setting on fire-, being mostly considered a negative response of the organism to the infection (pain, heat, redness, swelling and loss of function). However, we are now…
Elin Nyman, Maria Lindh, William Lövfors, Christian Simonsson + 5 more
Both initiation and suppression of inflammation are hallmarks of the immune response. If not balanced, the inflammation may cause extensive tissue damage, which is associated with common diseases, e.g. asthma and atherosclerosis. Anti-inflammatory drugs often come with severe side effects driven by high and fluctuating…
Ana Carolina G Salina, Stephanie Brandt, Nathan Klopfenstein, Amondrea Blackman + 6 more
The initial production of inflammatory mediators dictates host defense as well as tissue injury. Inflammasome activation is a constituent of the inflammatory response by recognizing pathogen and host-derived products and eliciting the production of IL-1β, IL-18 as well as inducing a type of inflammatory cell death…
Daniel Kalb, Huy D. Vo, Samantha Adikari, Elizabeth Hong-Geller + 2 more
IL-1β and TNFα are canonical immune response mediators that play key regulatory roles in a wide range of inflammatory responses to both chronic and acute conditions. Here we employ an automated microscopy platform for the analysis of messenger RNA (mRNA) expression of IL-1β and TNFα at the single-cell level. The amount…
Sridevi Nagaraja, Jaques Reifman, Alexander Y. Mitrophanov, Yoram Vodovotz
'Yoram Vodovotz'] Timely resolution of inflammation is critical for the restoration of homeostasis in injured or infected tissue. Chronic inflammation is often characterized by a persistent increase in the concentrations of inflammatory cells and molecular mediators, whose distinct amount and timing characteristics…
Kristen A. Windoloski, Elisabeth O. Bansgaard, A Dobréva, Johnny T. Ottesen + 1 more
'Johnny T. Ottesen' 'Mette S. Olufsen'] Abstract This study develops a unified model predicting the whole-body response to endotoxin. We simulate dynamics using differential equations examining the response to a lipopolysaccharide (LPS) injection. The model tracks pro- and antiinflammatory cytokines (TNF-, IL-6…
A Dobréva, Renee Brady‐Nicholls, Kamila Larripa, Charles Puelz + 2 more
'Jesper Mehlsen' 'Mette S. Olufsen'] Uncontrolled, excessive production of pro-inflammatory mediators from immune cells and traumatized tissues can cause systemic inflammatory issues like sepsis, one of the ten leading causes of death in the United States and one of the three leading causes of death in the intensive…
Authors not listed
Type 2 inflammation is an essential defense mechanism of the innate and adaptive immune systems, but when dysregulated, it can cause chronic atopic diseases like allergic asthma and atopic dermatitis. Thymic stromal lymphoprotein (TSLP) helps drive type 2 inflammation by guiding T cells toward a type 2 helper cell…
Stephanie Annett, Shaun Spence, Carolina Garciarena, Ciaran Campbell + 16 more
A breakdown in vascular integrity and excessive inflammation are hallmarks of serious pathological conditions including sepsis, acute respiratory distress syndrome (ARDs) and most recently, severe COVID-19. FK506 – binding protein like (FKBPL) is a member of the immunophilin protein superfamily with potent anti-tumor…
Yan Fu, Trevor Glaros, Meng Zhu, Ping Wang + 4 more
'John J. Tyson' 'Liwu Li' 'Jianhua Xing'] The innate immune system, acting as the first line of host defense, senses and adapts to foreign challenges through complex intracellular and intercellular signaling networks. Endotoxin tolerance and priming elicited by macrophages are classic examples of the complex adaptation…
Maria Bzówka, Weronika Bagrowska, Artur Góra
Toll-like receptors (TLRs) are transmembrane proteins which recognise various molecular patterns and activate signalling that triggers the immune response. In this review, our goal was to summarise how, in recent years, various computational solutions contributed to a better understanding of TLRs, regarding both their…
Bailey-Feliciano, Bryan, VanVeckhoven, George + 6 more
Chronic critical illness (CCI) is a disease state in which, following an initial insult, a patient neither recovers nor dies but instead remains in a state of critical illness. CCI is characterized by prolonged organ dysfunction, weight loss, and persistent increased vulnerability to infection. Recent data has shown…
Limeng Liu, Guannan Wang, Sandra E. Safo
Inflammatory Bowel Disease (IBD), including Crohn's Disease (CD) and Ulcerative Colitis (UC), presents significant public health challenges due to its complex etiology. Motivated by the IBD study of the Integrative Human Microbiome Project, our objective is to identify microbial pathways that distinguish between CD, UC…
Kazeem Olanrewaju, Ashlee N. Ford Versypt
The human physiological system consists of several biological units carefully organized to engage in a bio-physicochemical interaction with complex fluids transporting nutritional and life-supporting species (oxygen and carbon dioxide) needed for the proper functioning of the body. The nutritional species are products…
Authors not listed
A steep, age‑related drop in nicotinamide adenine dinucleotide (NAD+) now ranks among the most reproducible molecular signatures of human aging, driving metabolic slowdown, mitochondrial dysfunction, DNA‑repair deficits, chronic inflammation, and stem‑cell fatigue. Boost NAD+ for Anti‑Aging: A Multidimensional Review…
Chuang Li, Yichen Wei, Chao Qin, Shifan Chen + 1 more
line-encoded receptors Authors: ['Chuang Li' 'Yichen Wei' 'Chao Qin' 'Shifan Chen' 'Xiaolong Shao'] - 2 College of Veterinary Medicine, China Agricultural University, Beijing, 100193, China - 3 School of Life and Environmental Sciences, The University of Sydney, Sydney, NSW 2006, Australia - 4 Section of Infection and…
Authors not listed
Toll-like receptors (TLRs) form the first barrier of the innate immune system. TLR8 is an important target to treat autoimmune diseases, since its ligand-induced degree of activation regulates immune response and associated hyperinflammation. Molecular dynamics (MD) simulations have been used to investigate…
Authors not listed
The design and development of Curcumin nanoparticles has attracted and established torrential research in nano formulation matrix. By appearance Curcumin is an orange crystalline powder which is derived or obtained from the herbs Curcumin Longa Linn (Zingiberaceae). The Curcumin is natural hydrophobic polyphenol…
Andrew Goetz, Laurence Morel, Purushottam Dixit
Impaired metabolism is recognized as an important contributor to pathogenicity of T cells in Systemic Lupus Erythematosus (SLE). Over the last two decades, we have acquired significant knowledge about the signaling and transcriptomic programs related to metabolic rewiring in healthy and SLE T cells. However, our…