Search · four archives
Search · four archives
22 papers · ranked by Valyu relevance
Fabian Herold, Alexander Törpel, Dennis Hamacher, Henning Budde + 4 more
'Liye Zou' 'Tilo Strobach' 'Notger G. Müller' 'Thomas Gronwald'] The different responses of humans to an apparently equivalent stimulus are called interindividual response variability. This phenomenon has gained more and more attention in research in recent years. The research field of exercise-cognition has also taken…
Elia Valentini, Alina Shindy, Viktor Witkovsky, Anne Stankewitz + 1 more
Here, we aimed to investigate the interindividual variability and the individual stability of induced EEG gamma oscillations to phasic noxious laser stimuli and innocuous tactile stimuli. The results showed a large individual topographical variability of the gamma responses, indicating a variety of underlying gamma…
Christine Morand
Polyphenols are the largest family of bioactive compounds in plant foods and represent a significant component of our diet. Evidence from large cohort studies and experimental research consistently indicates beneficial effects of polyphenol intake on cardiometabolic health (1-3). However, randomized controlled trials…
Georg Northoff, Jonas Daub, Dusan Hirjak
In their impressive commentary, Stanghellini and Mecacci pointed out one dimension which we neglected in our perspective , namely that the brain is intrinsically personal and thus individual. They cited unexpected sources like Iwan Petrowitsch Pawlow (1849-1936) and Alexander Romanowitsch Lurija (1902-1977) showing…
Esin Karahan, Luke Tait, Ruoguang Si, Ayşegül Özkan + 2 more
Individuals are different in their behavioural responses and cognitive abilities. Neural underpinnings of individual differences are largely unknown. Here, by using multimodal imaging data including diffusion MRI, functional MRI and MEG, we show the consistency of interindividual variation of connectivity across…
Daniel T. Corp, Hannah G. K. Bereznicki, Gillian M. Clark, George J. Youssef + 11 more
Interindividual variability of single and paired-pulse TMS data has limited the clinical and experimental applicability of these methods. This study brought together over 60 TMS researchers to create the largest known sample of individual participant single and paired-pulse TMS data to date, enabling a more…
Nicholas Judd, Michael Aristodemou, Torkel Klingberg, Rogier Kievit
Our performance on cognitive tasks fluctuates: the same individual completing the same task will differ in their response’s moment-to-moment. For decades cognitive fluctuations have been implicitly ignored - treated as measurement error - with a focus instead on aggregates such as mean performance. Leveraging dense…
Richard M Turner, B Kevin Park, Munir Pirmohamed
There is notable interindividual heterogeneity in drug response, affecting both drug efficacy and toxicity, resulting in patient harm and the inefficient utilization of limited healthcare resources. Pharmacogenomics is at the forefront of research to understand interindividual drug response variability, but although…
Olivia A. Grant, Meena Kumari, Leonard Schalkwyk, Nicolae Radu Zabet
Interindividual genetic variability is well characterised, but we still lack a complete catalogue of loci displaying variable and stable epigenetic patterns. Here, we report a catalogue of stable and variable interindividual DNA methylation in human whole blood by analysing the DNA methylation patterns in 3642…
Julien F. Ayroles, Sean M Buchanan, Chelsea Jenney, Kyobi Skutt-Kakaria + 4 more
'Kyobi Skutt-Kakaria' 'Jennifer K. Grenier' 'Andrew G. Clark' 'Daniel L. Hartl' 'Benjamin de Bivort'] 1 – Dept. of Organismic and Evolutionary Biology, Harvard University, Cambridge, MA 02138, USA. 2 – Harvard Society of Fellows, Harvard University, Cambridge, MA 02138, USA. 3 – Dept. of Molecular Biology and Genetics…
Anna C. Schneider, Omar Itani, Elizabeth Cronin, Nelly Daur + 2 more
Ionic current levels of identified neurons vary substantially across individual animals. Yet, under similar conditions, neural circuit output remains remarkably similar, particularly in motor circuits. At any time, a neural circuit is influenced by multiple neuromodulators which provide flexibility to its output. These…
Joshua F. Wiley, Bei Bei, John Trinder, Rachel Manber
Whilst most psychological research focuses on differences in means, a growing body of literature demonstrates the value of considering differences in intra-individual variability. Compared to the number of methods available for analyzing mean differences, there is a paucity of methods available for analyzing…
Authors not listed
Accurate modeling of drug concentration--time (C--t) profiles is central to pharmacokinetics (PK) and plays a critical role in both early-stage compound selection and late-stage individualized dosing. Traditional PK model offer mechanistic interpretability but often rely on rigid assumptions, extensive…
Julien F. Ayroles, Sean M. Buchanan, Chelsea Jenney, Kyobi Skutt-Kakaria + 4 more
Variability is ubiquitous in nature and a fundamental feature of complex systems. Few studies, however, have investigated variance itself as a trait under genetic control. By focusing primarily on trait means and ignoring the effect of alternative alleles on trait variability, we may be missing an important axis of…
Alexander Volkmann
Recently, the variability ratio (VR) effect size statistic has been used with increasing frequency in the study of differences in variation of a measured variable between two study populations. More specifically, the VR effect size statistic allows for the detection of treatment effect heterogeneity (TEH) of medical…
Yaron Ilan, Jacques Demongeot
Title: Simple Summary The Constrained Disorder Principle (CDP) helps us understand how biological systems manage noise to function well. This review looks at the connection between noise and biological systems at different levels, including genes, cells, and organs, and how this relationship can lead to problems when…
Dagan Jenkins
Incomplete penetrance is the rule rather than the exception in Mendelian disease. In syndromic monogenic disorders, phenotypic variability can be viewed as the combination of incomplete penetrance for each of multiple independent clinical features. Within genetically identical individuals, such as isogenic model…
Qi Zhao, Lingli Zhang, Chun Shen, Jie Zhang + 1 more
Most studies indicate that intelligence (g) is positively correlated with cortical thickness. However, the interindividual variability of cortical thickness has not been taken into account. In this study, we aimed to identify the association between intelligence and cortical thickness in adolescents from both the…
Satoshi Usami
Behavioral science researchers have shown strong interest in disaggregating withinperson relations from between-person differences (stable traits) using longitudinal data. In this paper, we propose a method of within-person variability score-based causal inference for estimating joint effects of time-varying continuous…
Marina Gorostiola González, Olivier J. M. Béquignon, Emma Manners, Anna Gaulton + 7 more
Bioactivity prediction is essential in computational drug discovery, particularly within virtual screening campaigns. Despite advancements in model architectures and features, the sparsity and quality of relevant training data remain a major bottleneck. Notably, genetic variance annotation, crucial for understanding…
Authors not listed
Physics-based methods such as protein-ligand binding free energy calculations have been increasingly adopted in early-stage drug discovery to prioritize promising compounds for synthesis. However, the accuracy of these methods is highly dependent on details of the calculation and choices made while preparing the…
Authors not listed
Optimizing the synthesis conditions of advanced materials is challenging, especially when outcomes are subject to inherent experimental uncertainties. Bayesian optimization is a popular tool for accelerating materials discovery, but its standard risk-neutral framework overlooks the variability of outcomes under…