19 papers · ranked by Valyu relevance
Joshua Griffith, Jiwoo Kim, Robin Cooper, C. Andrew Frank
Isoflurane causes muscle contraction in Drosophila melanogaster despite inducing hyperpolarized state Authors: Joshua Griffith, Jiwoo Kim, Robin Cooper, C. Andrew Frank Isoflurane is a commonly used volatile anesthetic; however, its mechanisms are not well characterized. To better understand mechanisms of action…
Ružena Čižmáriková, Ladislav Habala, Jindra Valentová, Li Li + 2 more
'Xuqin Li' 'Tao Ma'] The introduction of general anesthetics in the mid-19th century is considered one of the greatest contributions to medical practice. It was the first time that complicated surgical interventions became feasible, without putting an excessive strain on the patient. The first general…
Xiaodong Zhang, Crovace Antonio
Simple Summary Nonhuman primates (NHPs) mimic most aspects of the human and play a critical role in translational research of neurological diseases. Functional connectivity is frequently examined using resting-state functional MRI (rsfMRI) to assess the functional abnormality in the anesthetized animal brain. As…
Hanna Antila, Maria Ryazantseva, Dina Popova, Pia Sipilä + 17 more
A brief burst-suppressing isoflurane anesthesia has been shown to rapidly alleviate symptoms of depression in a subset of patients, but the neurobiological basis of these observations remains obscure. We show that a single isoflurane anesthesia produces antidepressant-like behavioural effects in the learned…
Mengchan Ou, Wenling Zhao, Jin Liu, Peng Liang + 4 more
'Tao Zhu' 'Cheng Zhou'] Title: Summary Volatile anesthetics induce hyperactivity during induction while producing anesthesia at higher concentrations. They also bidirectionally modulate many neuronal functions. However, the neuronal mechanism is unclear. The effects of isoflurane on sodium channel currents were…
Shany Nivinsky Margalit, Neta Gery Golomb, Omer Tsur, Aeyal Raz + 1 more
Anesthetic drugs are widely used in medicine and research to mediate loss of consciousness (LOC). Despite the vast use of anesthesia, how LOC affects cortical sensory processing and the underlying neural circuitry, is not well understood. We measured neuronal population activity in the visual cortices of awake and…
Samantha Wright, Matthew I. Banks, Aeyal Raz
To test the effect of Isoflurane on synaptic transmission of cortico-cortical and thalamocortical projections to the auditory cortex, and investigate how it modulates cortical sensory information processing to produce unconsciousness. Using murine auditory thalamocortical brain slices, afferent pathways from the medial…
LS Herbst, T Gaigher, AA Siqueira, SRL Joca + 2 more
Previous studies indicated that some general anesthetics induce long-term antidepressant and/or anxiolytic-like effects. This raises the concern about the use of anesthesia in surgeries that precede psycopharmacological tests, since it may be a potential bias on results depending on the experimental design used. To…
Christakis Constantinides, Kathy Murphy
To-this-date, the exact molecular, cellular, and integrative physiological mechanisms of anesthesia remain largely unknown. Published evidence indicates that anesthetic effects are multifocal and occur in a time-dependent and coordinated manner, mediated via central, local, and peripheral pathways. Their effects can be…
Michael Ortiz-Rios, Nikoloz Sirmpilatze, Jessica König, Susann Boreitus
Initiatives towards acquiring large-scale neuroimaging data in non-human primates promise improving translational neuroscience and cross-species comparisons. Crucial among these efforts is the need to expand sample sizes while reducing the impact of anesthesia on the functional properties of brain networks. Yet, the…
Lukas Martin Müller-Wirtz, Dustin Grimm, Frederic Walter Albrecht, Tobias Fink + 3 more
'Tobias Fink' 'Thomas Volk' 'Andreas Meiser' 'Spyros D. Mentzelopoulos'] Low-dose isoflurane stimulates spontaneous breathing. We, therefore, tested the hypothesis that isoflurane compared to propofol sedation for at least 48 h is associated with increased respiratory drive in intensive care patients after sedation…
S Redaelli, P Mangili, V Ormas, S Sosio + 4 more
'N Patroniti' 'A Pesenti'] Introduction We report our experience in the use of isoflurane for prolonged sedation in severe ARDS patients. Prolonged sedation in the ICU may be difficult because of tolerance, drug dependence and withdrawal, drug interactions and side effects. Inhaled anesthetics have been proposed for…
Patricia Wollstadt, Kristin K. Sellers, Lucas Rudelt, Viola Priesemann + 3 more
'Viola Priesemann' 'Axel Hutt' 'Flavio Fröhlich' 'Michael Wibral'] The disruption of coupling between brain areas has been suggested as the mechanism underlying loss of consciousness in anesthesia. This hypothesis has been tested previously by measuring the information transfer between brain areas, and by taking…
Zhiyi Zuo
Volatile anesthetics are one class of the most commonly used drugs. However, the mechanisms for these drugs to induce anesthesia are not fully understood and have been under intensive investigation. Two other effects of these anesthetics on the central nervous system, volatile anesthetics-induced neuroprotection and…
Authors not listed
Fluorochemicals improve our quality of life, there is however increasing concern over how they are made and their negative impacts on health and the environment. Here we report an approach to the recycling of fluorochemicals. Treatment of hydrofluorocarbons with a potassium base (KHMDS, KOtBu) results in rapid…
Roberto N. Muñoz, Angus Leung, Felix A. Pollock, Dror Cohen + 3 more
'Bruno van Swinderen' 'Naotsugu Tsuchiya' 'Kavan Modi'] We apply techniques from the field of computational mechanics to evaluate the statistical complexity of neural recording data from fruit flies. First, we connect statistical complexity to the flies' level of conscious arousal, which is manipulated by general…
Kunkun Zhang, Qianwei Zhou
Decoders of anesthetic state from cortical activity fail across drug classes, most notoriously ketamine, but reported accuracy cannot say whether the neural representation or only the decision threshold has failed; we separate the two in a controlled preparation with ground-truth labels. We decoded awake versus…
Amitai Bickel, Alexey Gavrilov, Shimon Ivry, Neta B Maimon + 2 more
'Lior Molcho' 'Nathan Intrator'] Background: Post-operative cognitive dysfunction/ decline is a well-known phenomenon and of crucial importance especially in the elderly, emphasizing the significance of selecting the proper anesthetics. General anesthesia can be accomplished by inhalation-based (volatile) or total…
Martin G. Frasch, Bernd Walter, Christophe L. Herry, Reinhard Bauer
Ischemic brain injuries are frequent and difficult to detect reliably or early. We present the multi-modal data set containing cardiovascular (blood pressure, blood flow, electrocardiogram) and brain electrical activities to derive electroencephalogram (EEG) biomarkers of corticothalamic communication under normal…