29 papers · ranked by Valyu relevance
Hossein Rayat Pisheh, Mobin Haghdel, Mahboube Jahangir, Monireh Sadat Hoseinian + 2 more
'Monireh Sadat Hoseinian' 'Shaghayegh Rostami Yasuj' 'Ali Sarhadi Roodbari'] Kidney disease encompasses a wide spectrum of conditions, ranging from simple infections to chronic kidney disease. When the kidneys are unable to filter blood and remove waste products, these abnormalities can lead to kidney failure. In…
V Sivakamasundari, Mohan Bolisetty, Santhosh Sivajothi, Shannon Bessonett + 2 more
The human kidney is a complex organ composed of specialized cell types. To better define this cellular complexity, we profiled the individual transcriptomes of 22,469 normal human kidney cells, identifying 27 cell types. We describe three distinct endothelial cell populations, a novel subset of intercalated cells…
Biao Huang, Zipeng Zeng, Chennan C. Zhang, Megan E. Schreiber + 1 more
'Zhongwei Li'] One out of seven people develop chronic kidney disease (CKD). When kidney function continues to decline, CKD patients may develop end-stage renal disease (ESRD, or kidney failure). More than 2 out of 1,000 adults develop ESRD and these patients must live on dialysis or get a kidney transplant to survive.…
Bhavishya Maddineni, Ashlee N. Ford Versypt
The functioning of kidneys on blood flow regulation was investigated, particularly under diseased conditions such as chronic kidney disease, which includes conditions of diabetic nephropathy and other glomerular damage. A mathematical model was developed to better understand how variations based on the glomerular…
Bridgette E. Drummond, Brooke E. Chambers, Hannah M. Wesselman, Marisa N. Ulrich + 5 more
Knowledge about the genetic pathways that control renal cell lineage development is essential to better understand the basis of congenital malformations of the kidney and design regenerative medicine therapies. The embryonic zebrafish kidney, or pronephros, contains two nephrons that are conserved with humans.…
Mariel Bedell, Claire Yilin Lin, Emmie Román-Meléndez, Ioannis Sgouralis
'Ioannis Sgouralis'] The pressure in the renal interstitium is an important factor for normal kidney function. Here we develop a computational model of the rat kidney and use it to investigate the relationship between arterial blood pressure and interstitial fluid pressure. In addition, we investigate how tissue…
Mark E. Corkins, MaryAnne Achieng, Bridget D. DeLay, Vanja Krneta-Stankic + 5 more
The kidney is an essential organ that ensures bodily fluid homeostasis and removes soluble waste products from the organism. The functional units within the kidneys are epithelial tubules called nephrons. These tubules take in filtrate from the blood or coelom and selectively reabsorb nutrients through evolutionarily…
Mark E. Corkins, Adrian Romero, MaryAnne A. Achieng, Nils O. Lindström + 1 more
The vertebrate kidney develops through three sequential forms: the pronephros, mesonephros, and metanephros. These three forms are composed of segmented nephrons that mediate fluid filtration and solute homeostasis. In aquatic egg-laying vertebrates such as Xenopus laevis, the mesonephros serves as the final functional…
Mark E. Corkins, Adrian Romero-Mora, MaryAnne A. Achieng, Nils O. Lindström + 1 more
The mammalian kidney develops in three sequential stages referred to as the pronephros, mesonephros, and metanephros, each developing from the preceding form. All three phases of kidney development utilize epithelized tubules called nephrons, which function to take in filtrate from the blood or coelom and selectively…
Piotr Fularski, Witold Czarnik, Hanna Frankenstein, Magdalena Gąsior + 4 more
'Ewelina Młynarska' 'Jacek Rysz' 'Beata Franczyk' 'Prabhatchandra Dube'] Currently, more and more people are suffering from chronic kidney disease (CKD). It is estimated that CKD affects over 10% of the population worldwide. This is a significant issue, as the kidneys largely contribute to maintaining homeostasis by…
Hamid Nasri, Mahmoud Rafieian-Kopaei
Context: World kidney day is a yearly global alertness and education ceremony, held on the second Thursday in March. Evidence Acquisition: Directory of open access journals (DOAJ), EMBASE, Google Scholar, PubMed, EBSCO, and Web of Science have been searched. Results: Once again we reached to March 14, the world kidney…
Adoni Fernando, Nivethika Sivakumaran
This review was written to provide a comprehensive summary of the suggested etiologies of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka. In this review, Chronic Kidney Disease (CKD) is explained in detail and its known etiologies are discussed. CKDu is defined and its epidemiology is discussed, with…
Pritha Dutta, Anita T. Layton
Renal hemodynamics, renal transporter expression levels, and urine excretion all exhibit circadian variations. Disturbance of these diurnal patterns is associated with hypertension and chronic kidney disease. Renal hemodynamics determines oxygen delivery, whereas renal transport and metabolism determines oxygen…
Charlotte A Veser, Aurélie Carlier, Silvia M. Mihăilă, Sangita Swapnasrita
'Sangita Swapnasrita'] In vitro models play a crucial role in advancing our understanding of biological processes, disease mechanisms, and developing screening platforms for drug discovery. Kidneys play an instrumental role in transport and elimination of drugs and toxins. However, despite the wellestablished…
Chukwuka Elendu, Rhoda C. Elendu, Joy M. Enyong, Jennifer O. Ibhiedu + 18 more
Chronic kidney disease (CKD) is a prevalent and progressive condition affecting millions worldwide. It is a long-term condition characterized by gradual loss of kidney function over time. The management of CKD is complex and requires a multidisciplinary approach. This review aims to outline the current management…
Shi Yin, Qinmu Peng, Hongming Li, Zhengqiang Zhang + 4 more
'Susan L. Furth' 'Gregory E. Tasian' 'Yong Fan'] Abstract: It remains challenging to automatically segment kidneys in clinical ultrasound (US) images due to the kidneys' varied shapes and image intensity distributions, although semi-automatic methods have achieved promising performance. In this study, we propose…
Niharika, Rabea Parveen, Bushra Parveen, Shahid Umar + 1 more
Chronic kidney disease (CKD) presents a significant global health concern due to its progressive impact on kidney function, and associated complications. This narrative review highlights the role of traditional system of medicine and comprehensive approach to managing chronic kidney disease (CKD) including their…
Rongyuan Zhang, Ping Shen, Yu Xiong, Tianjing Wu + 12 more
Kidney transplantation is the gold standard for the treatment of end-stage renal disease (ESRD). However, the scarcity of kidneys has caused more and more ESRD patients being stuck on the waiting-list for surgery. Improving the survival rate of kidney grafts as much as possible is not only responsible for patients, but…
Vladislava Zohdi, Megan R. Sutherland, Kyungjoon Lim, Lina Gubhaju + 2 more
'Monika A. Zimanyi' 'M. Jane Black'] Epidemiological studies have clearly demonstrated a strong association between low birth weight and long-term renal disease. A potential mediator of this long-term risk is a reduction in nephron endowment in the low birth weight infant at the beginning of life. Importantly, nephrons…
Ehsan Khan, Avishek Choudhury, Amy L. Friedman, Daehan Won
The burgeoning need for kidney transplantation mandates immediate attention. Mismatch of deceased donor-recipient kidney leads to post-transplant death. To ensure ideal kidney donor-recipient match and minimize post-transplant deaths, the paper develops a prediction model that identifies factors that determine the…
Kazeem Olanrewaju, Ashlee N. Ford Versypt
The human physiological system consists of several biological units carefully organized to engage in a bio-physicochemical interaction with complex fluids transporting nutritional and life-supporting species (oxygen and carbon dioxide) needed for the proper functioning of the body. The nutritional species are products…
F. Boubred, M. Saint-Faust, C. Buffat, I. Ligi + 2 more
'U. Simeoni'] Cardiovascular diseases are one of the leading causes of mortality. Hypertension (HT) is one of the principal risk factors associated with death. Chronic kidney disease (CKD), which is probably underestimated, increases the risk and the severity of adverse cardiovascular events. It is now recognized that…
Authors not listed
Infrared (IR) spectroscopy of urine extracts coupled with Machine Learning (ML) methods has been proposed as a promising technique for Diabetic Kidney Disease (DKD) screening. However, for clinical translation, predictive models based on machine learning techniques necessitate substantial sets of samples for…
Authors not listed
Organic anion transporters (OAT1) are proteins that are located in the kidney and are responsible for excretion of metabolic byproducts, toxins, and drugs from the blood. Inhibiting these transporters can help in regulating the drug concentrations in the bloodstream. Recently, two separate studies have elucidated the…
Xiao‐Jun Tian, Dong Zhou, Haiyan Fu, Rong Zhang + 4 more
'Sui Huang' 'Youhua Liu' 'Jianhua Xing'] Tissue fibrosis compromises organ function and occurs as a potential long-term outcome in response to acute tissue injuries. Currently, lack of mechanistic understanding prevents effective prevention and treatment of the progression from acute injury to fibrosis. Here, we…
Authors not listed
When the kidneys are injured, uremic toxins (UTXs) accumulate in the body, affecting other tissues and causing a loss of essential body functions. This study investigated the adsorption of blood plasma-laden uremic toxins on the surface of PCL fibers to assess their potential as an alternative to membrane dialysis…
Olufunke Olugbenga, Joy Okpuzor
A total of 35 female albino rats were divided into 7 groups: control, rats exposed to carcinogen, treated with varying concentrations of Senna alata plant aqueous extracts, treated with standard drug, and untreated for total 28 days of treatment.. Freshly prepared 3 fractionated doses of 50mg/kg N-Nitroso-N-ethyl urea…
Robyn F. R. Letts, David M. Rubin, Robert Louw, Diane Hildebrandt
—Various models have been proposed to explain the urine concentrating mechanism in mammals, however uncertainty remains regarding the origin of the energy required for the production of concentrated urine. We propose a novel mechanism for concentrating urine. We postulate that the energy for the concentrating process…
Koichi Handa, Saki Yoshimura, Michiharu Kageyama, Takeshi Iijima
AI is expected to help identify excellent candidates in drug discovery. However, we face a lack of data as it is time consuming and expensive to acquire raw data perfectly for many compounds. Hence, we tried to develop a novel QSAR method to predict a parameter more precisely from an incomplete dataset via optimizing…