24 papers · ranked by Valyu relevance
Salvador Cazorla-Vázquez, Felix B. Engel
Chronic kidney disease (CKD) represents the fastest growing pathology worldwide with a prevalence of >10% in many countries. In addition, kidney cancer represents 5% of all new diagnosed cancers. As currently no effective therapies exist to restore kidney function after CKD- as well as cancer-induced renal damage, it…
Katrina Chan, Xiaogang Li, Vasilios Tsarouhas
The kidney is among the best characterized developing tissues, with the genes and signaling pathways that regulate embryonic and adult kidney patterning and development having been extensively identified. It is now widely understood that DNA methylation and histone modification patterns are imprinted during embryonic…
You-Lin Tain, Chien-Ning Hsu, Alexis A. Gonzalez
The complex relationship between kidney disease and hypertension represents a critical area of research, yet less attention has been devoted to exploring how this connection develops early in life. Various environmental factors during pregnancy and lactation can significantly impact kidney development, potentially…
Eugenie R. Lumbers, Yoga Kandasamy, Sarah J. Delforce, Amanda C. Boyce + 2 more
'Amanda C. Boyce' 'Karen J. Gibson' 'Kirsty G. Pringle'] Chronic kidney disease (CKD) can have an insidious onset because there is a gradual decline in nephron number throughout life. There may be no overt symptoms of renal dysfunction until about two thirds or more of the nephrons have been destroyed and glomerular…
Joseph M. Chambers, Robert A. McKee, Bridgette E. Drummond, Rebecca A. Wingert
'Rebecca A. Wingert'] The kidney is a complex organ whose excretory and regulatory functions are vital for maintaining homeostasis. Previous techniques used to study the kidney, including various animal models and 2D cell culture systems to investigate the mechanisms of renal development and regeneration have many…
Jonathan Levinsohn, Samuel Grindel, Bernhard Dumoulin, Amin Abedini + 17 more
Cell-cell interactions play a pivotal role in organ development, yet these communications have previously been studied one interaction at a time in model organisms, leaving a gap in our understanding of the cellular interplay in human development. To address this, we investigated human kidney development using…
Vladislava Zohdi, Megan R. Sutherland, Kyungjoon Lim, Lina Gubhaju + 2 more
'Monika A. Zimanyi' 'M. Jane Black'] Epidemiological studies have clearly demonstrated a strong association between low birth weight and long-term renal disease. A potential mediator of this long-term risk is a reduction in nephron endowment in the low birth weight infant at the beginning of life. Importantly, nephrons…
Zhen Miao, Michael S. Balzer, Ziyuan Ma, Hongbo Liu + 10 more
Determining the epigenetic program that generates unique cell types in the kidney is critical for understanding cell-type heterogeneity during tissue homeostasis and injury response. Here, we profiled open chromatin and gene expression in developing and adult mouse kidneys at single cell resolution. We show critical…
Mark E. Corkins, MaryAnne Achieng, Bridget D. DeLay, Vanja Krneta-Stankic + 5 more
The kidney is an essential organ that ensures bodily fluid homeostasis and removes soluble waste products from the organism. The functional units within the kidneys are epithelial tubules called nephrons. These tubules take in filtrate from the blood or coelom and selectively reabsorb nutrients through evolutionarily…
Mark E. Corkins, Adrian Romero, MaryAnne A. Achieng, Nils O. Lindström + 1 more
The vertebrate kidney develops through three sequential forms: the pronephros, mesonephros, and metanephros. These three forms are composed of segmented nephrons that mediate fluid filtration and solute homeostasis. In aquatic egg-laying vertebrates such as Xenopus laevis, the mesonephros serves as the final functional…
Mark E. Corkins, Adrian Romero-Mora, MaryAnne A. Achieng, Nils O. Lindström + 1 more
The mammalian kidney develops in three sequential stages referred to as the pronephros, mesonephros, and metanephros, each developing from the preceding form. All three phases of kidney development utilize epithelized tubules called nephrons, which function to take in filtrate from the blood or coelom and selectively…
Biao Huang, Zipeng Zeng, Chennan C. Zhang, Megan E. Schreiber + 1 more
'Zhongwei Li'] One out of seven people develop chronic kidney disease (CKD). When kidney function continues to decline, CKD patients may develop end-stage renal disease (ESRD, or kidney failure). More than 2 out of 1,000 adults develop ESRD and these patients must live on dialysis or get a kidney transplant to survive.…
Denis Menshykau, Dagmar Iber
The main signalling proteins that control early kidney branching have been defined. Yet the underlying mechanism is still elusive. We have previously shown that a Schnakenberg-type Turing mechanism can recapitulate the branching and protein expression patterns in wildtype and mutant lungs, but it is unclear whether…
Christine Lang, Lisa Conrad, Dagmar Iber
A common developmental process, called branching morphogenesis, generates the epithelial trees in a variety of organs, including the lungs, kidneys, and glands. How branching morphogenesis can create epithelial architectures of very different shapes and functions remains elusive. In this review, we compare branching…
Anika Schumacher, Virginie Joris, Martijn van Griensven, Vanessa LaPointe
Induced pluripotent stem cell (iPSC)–derived kidney organoids have the potential for a large variety of applications. However, they do not persist long in culture, for which reasons are still unclear. Furthermore, their morphological maturation, an essential feature for kidney function, has not been sufficiently…
Előd Méhes, Tana S. Pottorf, Márton Gulyás, Sándor Paku + 2 more
'Pamela V. Tran' 'András Czirók'] A critical barrier in the nephrology field is the lack of appropriate in vitro renal tubule models that allow manipulation of various mechanical factors, facilitating studies of disease pathophysiology and drug discovery. Here we report development of a novel in vitro assay system…
Charlotte A Veser, Aurélie Carlier, Silvia M. Mihăilă, Sangita Swapnasrita
'Sangita Swapnasrita'] In vitro models play a crucial role in advancing our understanding of biological processes, disease mechanisms, and developing screening platforms for drug discovery. Kidneys play an instrumental role in transport and elimination of drugs and toxins. However, despite the wellestablished…
Jingying Ma, Jinwei Wang, Lihua Lu, Yexiang Sun + 5 more
based on Deep Learning: A Real-World Study with External Validation Authors: ['Jingying Ma' 'Jinwei Wang' 'Lihua Lu' 'Yexiang Sun' 'Mengling Feng' 'Peng Shen' 'Zhiqin Jiang' 'Shenda Hong' 'Luxia Zhang'] Background. Chronic kidney disease (CKD), a progressive disease with high morbidity and mortality, has become a…
Kazeem Olanrewaju, Ashlee N. Ford Versypt
The human physiological system consists of several biological units carefully organized to engage in a bio-physicochemical interaction with complex fluids transporting nutritional and life-supporting species (oxygen and carbon dioxide) needed for the proper functioning of the body. The nutritional species are products…
Xiao‐Jun Tian, Dong Zhou, Haiyan Fu, Rong Zhang + 4 more
'Sui Huang' 'Youhua Liu' 'Jianhua Xing'] Tissue fibrosis compromises organ function and occurs as a potential long-term outcome in response to acute tissue injuries. Currently, lack of mechanistic understanding prevents effective prevention and treatment of the progression from acute injury to fibrosis. Here, we…
Authors not listed
Infrared (IR) spectroscopy of urine extracts coupled with Machine Learning (ML) methods has been proposed as a promising technique for Diabetic Kidney Disease (DKD) screening. However, for clinical translation, predictive models based on machine learning techniques necessitate substantial sets of samples for…
Rongyuan Zhang, Ping Shen, Yu Xiong, Tianjing Wu + 12 more
Kidney transplantation is the gold standard for the treatment of end-stage renal disease (ESRD). However, the scarcity of kidneys has caused more and more ESRD patients being stuck on the waiting-list for surgery. Improving the survival rate of kidney grafts as much as possible is not only responsible for patients, but…
Authors not listed
Organic anion transporters (OAT1) are proteins that are located in the kidney and are responsible for excretion of metabolic byproducts, toxins, and drugs from the blood. Inhibiting these transporters can help in regulating the drug concentrations in the bloodstream. Recently, two separate studies have elucidated the…
Vincent Blay, F. Gráses
Kidney stone disease poses a major burden to patients and healthcare systems around the world [1]. The formation of kidney stones may occur over months or years, but many patients are diagnosed at a late stage, suffer excruciating pain, and require surgical intervention to physically remove the stones. The prevalence…