24 papers · ranked by Valyu relevance
Julio Palomino, Raquel Echavarria, Adriana Franco-Acevedo, Bibiana Moreno-Carranza + 1 more
'Bibiana Moreno-Carranza' 'Zesergio Melo'] Kidneys have an important role in regulating water volume, blood pressure, secretion of hormones and acid-base and electrolyte balance. Kidney dysfunction derived from acute injury can, under certain conditions, progress to chronic kidney disease. In the late stages of kidney…
Anil Kumar Pasupulati, Sreenivasulu Kilari, Manisha Sahay
The principal function of the kidneys is to keep the blood clean and chemically balanced by filtering out waste products of metabolism and maintaining water, electrolyte, and acid-base balance. Kidneys help retain glucose, amino acids, vitamins, hormones, albumin, antibodies and other vital components in the blood…
Bhavishya Maddineni, Ashlee N. Ford Versypt
The functioning of kidneys on blood flow regulation was investigated, particularly under diseased conditions such as chronic kidney disease, which includes conditions of diabetic nephropathy and other glomerular damage. A mathematical model was developed to better understand how variations based on the glomerular…
Alexander Muacevic, John R Adler, Meaad A Almazmomi, Ahmed Esmat + 1 more
'Anjum Naeem'] Acute kidney injury (AKI) is caused by a sudden loss of renal function, resulting in the build-up of waste products and a significant increase in mortality and morbidity. It is commonly diagnosed in critically ill patients, with its occurrence estimated at up to 50% in patients hospitalized in the…
Tania Naber, Sharad Purohit, Omorogieva Ojo, Amanda Adegboye + 1 more
'Pietro Manuel Ferraro'] Chronic kidney disease affects ~37 million adults in the US, and it is often undiagnosed due to a lack of apparent symptoms in early stages. Chronic kidney disease (CKD) interferes with the body’s physiological and biological mechanisms, such as fluid electrolyte and pH balance, blood pressure…
Biao Huang, Zipeng Zeng, Chennan C. Zhang, Megan E. Schreiber + 1 more
'Zhongwei Li'] One out of seven people develop chronic kidney disease (CKD). When kidney function continues to decline, CKD patients may develop end-stage renal disease (ESRD, or kidney failure). More than 2 out of 1,000 adults develop ESRD and these patients must live on dialysis or get a kidney transplant to survive.…
Piotr Fularski, Witold Czarnik, Hanna Frankenstein, Magdalena Gąsior + 4 more
'Ewelina Młynarska' 'Jacek Rysz' 'Beata Franczyk' 'Prabhatchandra Dube'] Currently, more and more people are suffering from chronic kidney disease (CKD). It is estimated that CKD affects over 10% of the population worldwide. This is a significant issue, as the kidneys largely contribute to maintaining homeostasis by…
Sheila Marques Fernandes, Mirian Watanabe, Maria de Fátima Fernandes Vattimo
'Maria de Fátima Fernandes Vattimo'] Title: Abstract Inflammatory processes are believed to play an important role in immune response to maintain tissue homeostasis by activating cellular signaling pathways and releasing inflammatory mediators in the injured tissue. Although acute inflammation can be considered…
Adoni Fernando, Nivethika Sivakumaran
This review was written to provide a comprehensive summary of the suggested etiologies of Chronic Kidney Disease of Unknown Etiology (CKDu) in Sri Lanka. In this review, Chronic Kidney Disease (CKD) is explained in detail and its known etiologies are discussed. CKDu is defined and its epidemiology is discussed, with…
Yitian Fang, Anton V. Nikolaev, Jeroen Essers, Gisela Ambagtsheer + 4 more
'Marian C. Clahsen‐van Groningen' 'Robert C. Minnee' 'Ron W.F. de Bruin' 'Gijs van Soest'] Methods Porcine kidneys (n=22) retrieved from a local slaughterhouse underwent 2 hours of NMP. Based on creatinine clearance (CrCl) and oxygen consumption (VO2), the kidneys were classified as functional (n=7) and non-functional…
Shun Kishimoto, Kazumasa Horie, Nallathamby Devasahayam, Kota Yamashita + 7 more
Renal oxygenation is essential for maintaining kidney function. Disruptions in oxygen delivery can lead to renal hypoxia, which can exacerbate kidney injury through multiple pathways, including inflammation, oxidative stress, and ischemia-reperfusion injury. Despite the recognized importance of oxygenation in renal…
Mark E. Corkins, Adrian Romero, MaryAnne A. Achieng, Nils O. Lindström + 1 more
The vertebrate kidney develops through three sequential forms: the pronephros, mesonephros, and metanephros. These three forms are composed of segmented nephrons that mediate fluid filtration and solute homeostasis. In aquatic egg-laying vertebrates such as Xenopus laevis, the mesonephros serves as the final functional…
Mark E. Corkins, Adrian Romero-Mora, MaryAnne A. Achieng, Nils O. Lindström + 1 more
The mammalian kidney develops in three sequential stages referred to as the pronephros, mesonephros, and metanephros, each developing from the preceding form. All three phases of kidney development utilize epithelized tubules called nephrons, which function to take in filtrate from the blood or coelom and selectively…
Vincent Mathias Brandenburg, Turgay Saritas
Chronic kidney disease (CKD) is a world-wide phenomenon with an increasing incidence and prevalence. In 2017, the global prevalence of CKD was 9.1%, which corresponds to roughly 700 million cases [1]. CKD is much more than one or more lab values diverging from the normal range. Compared with other risk factors, reduced…
Prasanna Katti, Praveena Prasad, Sepiso K. Masenga, Prasanna Venkhatesh + 43 more
Due to aging, the efficiency of kidney function begins to decrease. Dysfunction in mitochondria and their cristae is a hallmark of aging. Therefore, age-related decline in kidney function could be attributed to changes in mitochondrial ultrastructure, increased reactive oxygen species, and alterations in metabolism and…
Zer Vue, Praveena Prasad, Han Le, Kit Neikirk + 48 more
The kidney filters nutrient waste and bodily fluids from the bloodstream, in addition to secondary functions of metabolism and hormone secretion, requiring an astonishing amount of energy to maintain its functions. In kidney cells, mitochondria produce adenosine triphosphate (ATP) and help maintain kidney function. Due…
Kazeem Olanrewaju, Ashlee N. Ford Versypt
The human physiological system consists of several biological units carefully organized to engage in a bio-physicochemical interaction with complex fluids transporting nutritional and life-supporting species (oxygen and carbon dioxide) needed for the proper functioning of the body. The nutritional species are products…
Lanyan Qiu, Jingke Zhang, Yi Yang, Hong Zhang + 6 more
'Qiong He' 'Chengwu Huang' 'Lijie Huang' 'Linxue Qian' 'Jianwen Luo'] Purpose: As a typical chronic kidney disease (CKD), hypertensive nephrosclerosis (HN) is a common syndrome of hypertension, characterized by chronic kidney microvascular damage. Early diagnosis of microvascular damage using conventional ultrasound…
Tuo Wang, Yu Du
Chronic kidney disease (CKD) is a global health challenge characterized by progressive kidney function decline, often culminating in end-stage kidney disease (ESKD) and increased mortality. To address the limitations such as the extended trial follow-up necessitated by the low incidence of kidney composite endpoint…
Rongyuan Zhang, Ping Shen, Yu Xiong, Tianjing Wu + 12 more
Kidney transplantation is the gold standard for the treatment of end-stage renal disease (ESRD). However, the scarcity of kidneys has caused more and more ESRD patients being stuck on the waiting-list for surgery. Improving the survival rate of kidney grafts as much as possible is not only responsible for patients, but…
Charlotte A Veser, Aurélie Carlier, Silvia M. Mihăilă, Sangita Swapnasrita
'Sangita Swapnasrita'] In vitro models play a crucial role in advancing our understanding of biological processes, disease mechanisms, and developing screening platforms for drug discovery. Kidneys play an instrumental role in transport and elimination of drugs and toxins. However, despite the wellestablished…
Authors not listed
Infrared (IR) spectroscopy of urine extracts coupled with Machine Learning (ML) methods has been proposed as a promising technique for Diabetic Kidney Disease (DKD) screening. However, for clinical translation, predictive models based on machine learning techniques necessitate substantial sets of samples for…
Authors not listed
Organic anion transporters (OAT1) are proteins that are located in the kidney and are responsible for excretion of metabolic byproducts, toxins, and drugs from the blood. Inhibiting these transporters can help in regulating the drug concentrations in the bloodstream. Recently, two separate studies have elucidated the…
Koichi Handa, Saki Yoshimura, Michiharu Kageyama, Takeshi Iijima
AI is expected to help identify excellent candidates in drug discovery. However, we face a lack of data as it is time consuming and expensive to acquire raw data perfectly for many compounds. Hence, we tried to develop a novel QSAR method to predict a parameter more precisely from an incomplete dataset via optimizing…