25 papers · ranked by Valyu relevance
Badri N Mishra
The euphoria of modern day health achievements is in an epidemiological cross road. We are going to lose out the hard caught health benefits to modern monsters such as obesity and its associated diseases. For example, the present American life expectancy of 77.8 years is expected to plummet due to the current trend of…
Brett N. Augsburger
Scientists have been unable to reach a consensus on why organisms age and why they live as long as they do. Here, a multidisciplinary approach was taken in an attempt to understand the root causes of aging. Nonequilibrium thermodynamics may play a previously unappreciated role in determining longevity by governing the…
Mikhail V. Blagosklonny
with "revealed-slow-aging" hypothesis "Revealed-slow-aging" hypothesis Authors: ['Mikhail V. Blagosklonny'] Healthy life span is rapidly increasing and human aging seems to be postponed. As recently exclaimed in Nature, these findings are so perplexing that they can be dubbed the 'longevity riddle'. To explain current…
Anđela Martinović, Matilde Mantovani, Natalia Trpchevska, Eva Novak + 9 more
'Nikolay B. Milev' 'Leonie Bode' 'Collin Y. Ewald' 'Evelyne Bischof' 'Tobias Reichmuth' 'Rebecca Lapides' 'Alexander Navarini' 'Babak Saravi' 'Elisabeth Roider'] Longevity medicine is an emerging and iterative healthcare discipline focusing on early detection, preventive measures, and personalized approaches that aim…
Livia Beccacece, Paolina Crocco, Benedetta Torbidoni-Baldassari, Stefano Pallotti + 6 more
Human longevity is a complex trait shaped by genetic background and population-specific factors. Calabria, a region in Southern Italy with a high prevalence of centenarians and relative genetic isolation, is a valuable model for investigating the genetic architecture of extreme survival. Here, we performed a…
Toni Ćosić, Roko Mišetić, Hrvoje Štefančić
The issue of longevity has been long time recognized as one of key concepts in demography. A particular aspect of longevity addressed in this paper is the difference in average observed duration of life for female and male population, called observed lifespan differential. Using the data from Human Mortality Database…
Genovefa D. Kolovou, Vana Kolovou, Sophie Mavrogeni
Ageing and longevity is unquestioningly complex. Several thoughts and mechanisms of ageing such as pathways involved in oxidative stress, lipid and glucose metabolism, inflammation, DNA damage and repair, growth hormone axis and insulin-like growth factor (GH/IGF), and environmental exposure have been proposed. Also…
Magdalini Kreouzi, Nikolaos Theodorakis, Constantina Constantinou
Blue Zones are regions of the world that have a higher number of individuals who live longer than the expected average. The current paper revisits principles previously identified to be common in Blue Zones and to be contributing to longevity (move naturally, eat wisely, improve resilience to stress, get adequate…
Jeremy Simon Cabot Clark, Kamila Rydzewska, Konrad Podsiadło, Thierry van de Wetering + 1 more
Longevity is of considerable interest. Collation of recent data after World War II by the Human Mortality Database allowed Analyses, previously unattainable, of modal death-ages for sufficient numbers of large European cohorts. to track all-cause “bulk” mortality for both sexes. The only high-quality, large-number…
Axel Kowald, Thomas B L Kirkwood
Human life expectancy has increased dramatically over the past two centuries, marking a significant public health achievement. While some projections predict a future where median lifespans reach 100 years, others contend that further longevity will depend on breakthroughs targeting the biological processes of aging.…
Jicun Wang-Michelitsch, Thomas M. Michelitsch
In order to understand the phenomenon of longevity in biological world, the relationship between the potential of longevity and the structural complexity of an organism is analyzed. I. The potential of longevity is the maximum lifespan of an organism if it lives in an "ideal" environment. The longevity of an organism…
Saul Newman, Easteal Simon
We respond to claims by Dong et al. that human lifespan is limited below 125 years. Using the log-linear increase in mortality rates with age to predict the upper limits of human survival we find, in contrast to Dong et al., that the limit to human lifespan is historically flexible and increasing. This discrepancy can…
Albert Solé-Ribalta, Javier Borge‐Holthoefer
The analysis of the demographic transition of the past century and a half, using both empirical data and mathematical models, has rendered a wealth of well-established facts, including the dramatic increases in life expectancy. Despite these insights, such analyses have also occasionally triggered debates which spill…
Léo R. Belzile, A. C. Davison, Holger Rootzén, Dmitrii Zholud
We use a combination of extreme value statistics, survival analysis and computer-intensive methods to analyze the mortality of Italian and French semi-supercentenarians. After accounting for the effects of the sampling frame, we conclude that constant force of mortality beyond 108 years describes the data well and…
Bill O'Neill
Is aging inevitable or can it be "cured"? Recent work from many different fields of science is now providing clues into why we age and how long we might live
Francis Heylighen
Aging is analyzed as the spontaneous loss of adaptivity and increase in fragility that characterizes dynamic systems. Cybernetics defines the general regulatory mechanisms that a system can use to prevent or repair the damage produced by disturbances. According to the law of requisite variety, disturbances can be held…
Authors not listed
A steep, age‑related drop in nicotinamide adenine dinucleotide (NAD+) now ranks among the most reproducible molecular signatures of human aging, driving metabolic slowdown, mitochondrial dysfunction, DNA‑repair deficits, chronic inflammation, and stem‑cell fatigue. Boost NAD+ for Anti‑Aging: A Multidimensional Review…
Holger Rootzén, Dmitrii Zholud
Does the human lifespan have an impenetrable biological upper limit which ultimately will stop further increase in life lengths? This question is important for understanding aging, and for society, and has led to intense controversies. Demographic data for humans has been interpreted as showing existence of a limit, or…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Sandeep Kumar, Timothy R. Peterson
As the global population ages, there is increased interest in living longer and improving one's quality of life in later years. However, studying aging – the decline in body function – is expensive and time-consuming. And despite research success to make model organisms live longer, there still aren't really any…
Elizabeth D Drake, Mirre J P Simons
Stochastic effects are central to the biology and demography of ageing. Genetically identical individuals do not all die at the exact same time but show a distribution of lifespan. Although such effects are appreciated, any cascading effects from stochastic effects of ageing are underappreciated. We show here that…
Mikhail V. Blagosklonny, Judith Campisi, David A. Sinclair
In his Foundation series, published in the 1950's, Isaac Asimov imagined Civilization capable of colonizing the entire Universe. This feat is unlikely to occur. Strikingly, Asimov referred to a 70-old man as an old individual who is unlikely to live much longer. Thus, in literature's most daring fantasy, the pace of…
Authors not listed
N¹-Methylnicotinamide (1-MNA), a quaternary pyridinium derivative of nicotinamide (vitamin B₃), represents a largely overlooked naturally occurring compound with remarkable potential as a next-generation anti-aging therapeutic. This comprehensive review examines 1-MNA's unique chemical properties, natural occurrence…
Xinyi Zhang, William Arnold, Natasha Wright, Paige Novak + 1 more
This study aims to support the prioritization of research and development (R&D) pathways of hydrogel-encapsulated anaerobic technology to treat high-strength organic industrial wastewaters, enabling decentralized energy recovery and treatment to reduce organic loading on centralized treatment facilities. To…
Authors not listed
Synthetic cells emulate fundamental biological behaviors, such as growth, metabolism, and evolution, under non-equilibrium conditions, but have lacked genotype-driven selection, which is essential for Darwinian evolution. Here, we introduce short DNA sequences as genotypes into fuel-dependent, peptide-RNA-based…