20 papers · ranked by Valyu relevance
Randi Wang, Vadim Shapiro
Behaviors of many engineering systems are described by lumped parameter models that encapsulate the spatially distributed nature of the system into networks of lumped elements; the dynamics of such a network is governed by a system of ordinary differential and algebraic equations. Languages and simulation tools for…
Laura Iannetti, Giovanna D’Urso, Gioacchino Conoscenti, Elena Cutrì + 5 more
'Rocky S. Tuan' 'Manuela T. Raimondi' 'Riccardo Gottardi' 'Paolo Zunino' 'Feng Zhao'] Next generation bioreactors are being developed to generate multiple human cell-based tissue analogs within the same fluidic system, to better recapitulate the complexity and interconnection of human physiology [1, 2]. The effective…
Feng Huang, Shunv Ying, Antonio Cannatà
A lumped model of the arterial system has been used in constructing a hybrid mock loop due to its real-time response. However, the parameters of the model are always from a general case and not adapted to a specific patient. In this study, we focused on on-line parameter identification of the lumped model of the…
James V. Koch, WoongJo Choi, Ethan King, David García + 4 more
'Hrishikesh Das' 'Tianhao Wang' 'Ken Ross' 'Keerti Kappagantula'] Lumped parameter methods aim to simplify the evolution of spatially-extended or continuous physical systems to that of a "lumped" element representative of the physical scales of the modeled system. For systems where the definition of a lumped element or…
Belén Casas, Jonas Lantz, Federica Viola, Gunnar Cedersund + 4 more
'Ann F. Bolger' 'Carl-Johan Carlhäll' 'Matts Karlsson' 'Tino Ebbers'] Lumped parameter models of the cardiovascular system have the potential to assist researchers and clinicians to better understand cardiovascular function. The value of such models increases when they are subject specific. However, most approaches to…
Michael J. Moulton, Timothy W. Secomb
The course of diseases such as hypertension, systolic heart failure and heart failure with a preserved ejection fraction are affected by interactions between the left ventricle (LV) and the vasculature. To study these interactions, a computationally efficient, biophysically based mathematical model for the circulatory…
Sadman Sadid, Matthew J. Eden, Fahim Usshihab Mobin, Micaela K. Gomez + 7 more
Uncontrolled hemorrhage remains a leading cause of traumatic death, driven by rapid physiological deterioration that is often difficult to detect during the compensated phase. While large-animal models provide critical insights into these dynamics, they are resource-intensive, motivating the need for efficient…
Mikael Sunnåker, Henning Schmidt, Mats Jirstrand, Gunnar Cedersund
Background Systems biology models tend to become large since biological systems often consist of complex networks of interacting components, and since the models usually are developed to reflect various mechanistic assumptions of those networks. Nevertheless, not all aspects of the model are equally interesting in a…
Alex Thornton, Ian Halliday, Harry Saxton, Xu Xu
We make modifications to the unscented Kalman filter (UKF) which bestow almost complete practical identifiability upon a lumped-parameter cardiovascular model with 10 parameters and 4 output observables - a highly non-linear, stiff problem of clinical significance. The modifications overcome the challenging problems of…
Amin Deyranlou, Alistair Revell, Amir Keshmiri
Lumped (zero-dimensional) technique is a robust and widely used approach to mathematically model and explore bulk behaviour of different physical phenomena in a lower expense. In modelling of cardio/cerebrovascular fluid dynamics, this technique facilitates the assessment of relevant metrics such as flow, pressure, and…
Authors not listed
Moving bed reactors (MBRs) are widely used in various industrial processes, making the development of mathematical models crucial for their design, optimization, and control. This study presents a semi-analytical solution (SAS) for a lumped parameter kinetic and heat transfer model of a tubular MBR, where a first-order…
Belén Casas, Kajsa Tunedal, Federica Viola, Gunnar Cedersund + 3 more
Subject-specific parameters in lumped hemodynamic models of the cardiovascular system can be estimated using data from experimental measurements, but the parameter estimation may be hampered by the variability in the input data. In this study, we investigate the influence of inter-sequence, intra-observer, and…
MT Cabeleira, S Ray, NC Ovenden, V Diaz-Zuccarini
Calibration of mechanistic cardiovascular models is a central barrier to their use in population analysis and patient-specific simulation, particularly in settings where key physiological variables are unobservable and multiple parameter combinations can reproduce the same haemodynamic targets. In this work, we present…
Yang Yang, Ting Fong May Chui
A lumped hydrological model structure can be considered a generative model because, given a set of parameter values, it can generate a hydrological modeling function that accurately predicts the behavior of a catchment under external forcing. It is implicitly assumed that a small number of variables (i.e., the model…
Florian U. Jehn, Alejandro Chamorro, Tobias Houska, Lutz Breuer
Tightly constraint parameter ranges are seen as an important goal in constructing hydrological models, a difficult task in complex models. However, many studies show that complex models are often good at capturing the behaviour of a river. Therefore, this study explores the trade-offs between tightly constrained…
Authors not listed
Microalgae-based tertiary wastewater treatment has the potential to meet stringent effluent phosphorus limits, with the added benefit of producing a marketable feedstock. However, the lack of validated mechanistic models and their implementation in process simulators have limited the adoption of this technology. In…
Authors not listed
This paper presents the Multi Cell-line Kinetic Model (MCKM), a novel generalised kinetic mechanistic model specifically tailored for Ambr15™ fed-batch cultivations of multiple Chinese Hamster Ovary (CHO) cell lines producing different recombinant monoclonal antibodies (mAbs). Unlike traditional models that requires…
Sarah Rutan, Kathryn Cash, Dwight Stoll II
The present work describes a re-parameterization of the Neue Kuss (NK) model for describing retention in liquid chromatography, and this re-parameterized model is used fit a large set of isocratic retention measurements with improved convergence properties relative to the original parameterization of the model. Next…
Nathaniel J. Linden, Boris Kramer, Padmini Rangamani
Dynamical systems modeling, particularly via systems of ordinary differential equations, has been used to effectively capture the temporal behavior of different biochemical components in signal transduction networks. Despite the recent advances in experimental measurements, including sensor development and ‘-omics’…
Sarah A. Vollert, Christopher Drovandi, Gloria M. Monsalve-Bravo, Matthew P. Adams
'Matthew P. Adams'] - We propose a new model reduction framework based on a sloppy analysis. - Model reduction is guided by identifying mechanisms which weakly inform predictions. - We successfully reduce a complex coral growth model, preserving predictive accuracy. - A Bayesian sloppy analysis is advantageous when the…