17 papers · ranked by Valyu relevance
Madoka Ozawa, Shihori Nakajima, Daichi Kobayashi, Koichi Tomii + 7 more
In the lymphatic vascular system, lymph nodes (LNs) play a pivotal role in filtering and removing lymph-borne substances. The filtering function of LNs involves resident macrophages tightly associated with unique lymphatic sinus structures. Moreover, an intermittently arranged LN in the lymphatic pathway is considered…
Thibaut Larcher, Sébastien Picault, Bertrand Bed’Hom, Laurence Dubreil + 3 more
It has been known for decades that pigs, as well as some other mammals, possess a peculiar lymph node architecture commonly referred to as “inverted”. Although some direct consequences of this structure have been described, such as the altered circulation pattern of mature lymphocytes, the overall impact of this…
Sean Sachdev, Chelain R. Goodman, Erin Neuschler, Kapila Kalakota + 6 more
'Daniel Cutright' 'Eric D. Donnelly' 'John P. Hayes' 'Adam E. Prescott' 'Gianna Mirabelli' 'Jonathan B. Strauss'] Background The internal mammary (IM) lymph node chain, along with the axillary nodal basin, is a first-echelon breast lymphatic draining site. A growing body of evidence supports irradiation of this region…
Binod Dhakal, Alexandra M. Harrington, Michael E. Stadler, Anita D'Souza
"Anita D'Souza"] Immunoglobulin-derived light chain amyloidosis can occasionally be associated with localized disease. We present a patient with localized lymph node light chain amyloidosis without an underlying monoclonal protein or lymphoproliferative disorder and review the literature of lymph node amyloidosis…
Esther Redder, Nils Kirschnick, Shentong Fang, Michael Kuhlmann + 8 more
Lymphatic vessels (LVs) are indispensable for tissue fluid homeostasis and immune cell trafficking. The network of LVs that channel fluids from the gut into mesenteric lymph nodes (MLN) has been recognized as the sole lymphatic system in the mesentery. Here we describe an alternative, functionally autonomous set of…
Morgan E. Brisse, Heather D. Hickman, Deepak Shukla
Many viruses induce viremia (virus in the blood) and disseminate throughout the body via the bloodstream from the initial infection site. However, viruses must often pass through the lymphatic system to reach the blood. The lymphatic system comprises a network of vessels distinct from blood vessels, along with…
Ke Yan, Dakai Jin, Dazhou Guo, Minfeng Xu + 4 more
'Xianghua Ye' 'Le Lü'] Abstract. Finding abnormal lymph nodes in radiological images is highly important for various medical tasks such as cancer metastasis staging and radiotherapy planning. Lymph nodes (LNs) are small glands scattered throughout the body. They are grouped or defined to various LN stations according…
Sofija Engelson, Jan Ehrhardt, Timo Kepp, Joshua Niemeijer + 1 more
Probabilistic Lymph Node Atlas Authors: ['Sofija Engelson' 'Jan Ehrhardt' 'Timo Kepp' 'Joshua Niemeijer' 'Heinz Handels'] | Engelson https://orcid.org/0009-0007-2493-8107 ∗ Sofija | sofija.engelson@uni-luebeck.de | | --- | --- | | Institute of Medical Informatics, University of L¨ubeck, L¨ubeck, Germany | | | ∗ Jan…
Ann Ramirez, Vedanth Sriram, Yassmin Abbouchi, Reina Patolia + 3 more
Lymph nodes are highly specialized immune organs that orchestrate the adaptive immune response. In the lymph nodes, naïve B and T lymphocytes encounter cognate antigens, sparking their activation and response to foreign substances. Lymph nodes grow in response to an immune challenge, at least in part to accommodate…
Yongrui Yu, Hanyu Chen, Zitian Zhang, Qiong Xiao + 7 more
Segmentation Authors: ['Yongrui Yu' 'Hanyu Chen' 'Zitian Zhang' 'Qiong Xiao' 'Wenhui Lei' 'Linrui Dai' 'Yu Fu' 'Tan Hui' 'Guan Wang' 'Peng Gao' 'Xiaofan Zhang'] Abstract. Despite the significant success achieved by deep learning methods in medical image segmentation, researchers still struggle in the computer-aided…
Lara V. Graham, Salim I. Khakoo, Matthew D. Blunt, Vincent Vieillard
The lymph nodes are vital to enable adaptive immune responses to infection. Natural killer (NK) cells are cytotoxic lymphocytes that directly kill cancer cells and modulate the activation of other immune cells during anti-tumour immune response. NK cells in the lymph nodes are involved in the regulation of T-cell and…
Maura C. Belanger, Alexander G. Ball, Megan A. Catterton, Andrew W.L. Kinman + 6 more
The lymph node is a highly organized and dynamic structure that is critical for facilitating the intercellular interactions that constitute adaptive immunity. Most ex vivo studies of the lymph node begin by reducing it to a cell suspension, thus losing the spatial organization, or fixing it, thus losing the ability to…
David Bouget, André Pedersen, Johanna Vanel, Haakon Olav Leira + 1 more
'Thomas Langø'] Purpose: As lung cancer evolves, the presence of enlarged and potentially malignant lymph nodes must be assessed to properly estimate disease progression and select the best treatment strategy. Following the clinical guidelines, estimation of short-axis diameter and mediastinum station are paramount for…
Danilo Pellin, Natalie Claudio, Ferdinando Pucci
Lymph nodes are key lymphoid organs collecting lymph fluid and migratory cells from the tissue area they survey. When cancerous cells arise within a tissue, the sentinel lymph node is the first immunological organ to mount an immune response. Sub-capsular sinus macrophages (SSMs) are specialized macrophages residing in…
Vincent Walter, Johanna Herold, Sophia Aurelie Feuchter, Sophie Thomä + 11 more
Tumor-draining lymph nodes (tdLNs) are critical hubs of anti-tumor immunity but are also vulnerable to tumor-mediated immunosuppression. We analyzed T cell and B cell receptor (TCR/BCR) repertoires and transcriptomes from sentinel and non-sentinel lymph nodes of patients with melanoma from a historical pre–immune…
Sangmin Choi, Jiho Park, Quan Dong Nguyen, André Cronje
| 1 | Introduction | | 2 | | --- | --- | --- | --- | | | 1.1 Contributions | | 2 | | | 1.2 Paper structure | | 2 | | 2 | Preliminaries | | 2 | | | 2.1 Basic Definitions | | 3 | | | 2.2 | Lamport timestamps | 4 | | | 2.3 | State Definitions | 4 | | | 2.4 | Consistent Cut | 5 | | | 2.5 | Dominator (graph theory) | 7 | |…
Pin-Ji Lei, Ethel R. Pereira, Patrik Andersson, Zohreh Amoozgar + 14 more
Tumor-draining lymph nodes are critical sites for generating tumor antigen-specific T cells and are associated with durable immune responses. However, lymph nodes are often the first site of metastasis and lymph node metastases portend worse outcomes. Through cross-species single cell gene expression analysis of breast…