28 papers · ranked by Valyu relevance
Francis EG Cox
Malaria is caused by infection with protozoan parasites belonging to the genus Plasmodium transmitted by female Anopheles species mosquitoes. Our understanding of the malaria parasites begins in 1880 with the discovery of the parasites in the blood of malaria patients by Alphonse Laveran. The sexual stages in the blood…
Mzwandile Thabani Hadebe, Samson Anjikwi Malgwi, Moses Okpeku, Brendan McMorran
'Brendan McMorran'] Many factors, such as the resistance to pesticides and a lack of knowledge of the morphology and molecular structure of malaria vectors, have made it more challenging to eradicate malaria in numerous malaria-endemic areas of the globe. The primary goal of this review is to discuss malaria vector…
Merveille Koissi Savi, Ignacio Martin-Loeches
In sub-Saharan Africa, malaria is a leading cause of mortality and morbidity. As a result of the interplay between many factors, the control of this disease can be challenging. However, few studies have demonstrated malaria’s complexity, control, and modeling although this perspective could lead to effective policy…
Pierre Fongho Suh, Emmanuel Elanga-Ndille, Magellan Tchouakui, Maurice Marcel Sandeu + 3 more
'Maurice Marcel Sandeu' 'Darus Tagne' 'Charles Wondji' 'Cyrille Ndo'] Since its first report in Anopheles mosquitoes in 1950s, insecticide resistance has spread very fast to most sub-Saharan African malaria-endemic countries, where it is predicted to seriously jeopardize the success of vector control efforts, leading…
Ayuya Stephen, Kitungulu Nicholas, Annette O. Busula, Mark Kilongosi Webale + 1 more
Re-emerging of high malaria incidences in highlands of western Kenya pose a challenge to malaria eradication efforts. Anopheles coustani is a sub-Saharan mosquito species implicated in transmission of malaria in many parts of Africa as a secondary vector. It is a zoo-anthropophilic species that has been assumed to be…
Jasminka Talapko, Ivana Škrlec, Tamara Alebić, Melita Jukić + 1 more
'Aleksandar Včev'] Malaria is a severe disease caused by parasites of the genus Plasmodium, which is transmitted to humans by a bite of an infected female mosquito of the species Anopheles. Malaria remains the leading cause of mortality around the world, and early diagnosis and fast-acting treatment prevent unwanted…
Eva English, Clara Gulick, Ashley Jane, Minseo Kim + 8 more
Anopheles gambiae or the African malaria mosquito is the main vector of human malaria. G3, is an Anopheles gambiae strain, that was isolated from Gambiae in 1975, We report here a 216.3 Mbp draft genome sequence and assembly for Anopheles gambiae strain G3, with almost 82 thousand scaffold, 53X coverage and a G+C…
Ilinca I. Ciubotariu, Christine M. Jones, Tamaki Kobayashi, Thierry Bobanga + 5 more
Despite ongoing malaria control efforts implemented throughout sub-Saharan Africa, malaria remains an enormous public health concern. Current interventions such as indoor residual spraying with insecticides and use of insecticide-treated bed nets are aimed at targeting the key malaria vectors that are primarily…
Rex B. Mbewe, John B. Keven, Themba Mzilahowa, Don Mathanga + 4 more
Background Access to human hosts by Anopheles mosquitoes is a key determinant of vectorial capacity for malaria, but it can be limited by use of long-lasting insecticidal nets (LLINs). In Malawi, pyrethroid-treated LLINs with and without the synergist piperonyl butoxide (PBO) were distributed to control malaria. This…
Melissa A. Iacovidou, Priscille Barreaux, Matthew B. Thomas, Erin E. Gorsich + 1 more
Mathematical models of vector-borne infections, including malaria, often assume age-independent mortality rates of vectors, despite evidence that many insects senesce. In this study we present survival data on insecticide-resistant Anopheles gambiae s.l. from field experiments in Côte d’Ivoire. We fit a constant…
Amber Gigi Hoi, Benjamin Gilbert, Nicole Mideo
Identifying determinants of global infectious disease burden is a central goal of disease ecology. While it is widely accepted that host diversity structures parasite diversity and prevalence across large spatial scales, the influence of vector diversity on disease risk has rarely been examined despite the role of…
Bhushan Kotnis, Joy Kuri
Malaria is a serious global health problem which is especially devastating to the developing world. Most malaria control programs use insecticides for controlling mosquito populations. Large scale usage of these insecticides exerts massive selection pressure on mosquitoes resulting in insecticide resistant mosquito…
Kamgang Jean Claude, Thron Christopher
We analyze an epidemiological model to evaluate the effectiveness of multiple means of control in malariaendemic areas. The mathematical model consists of a system of several ordinary differential equations, and is based on a multicompartment representation of the system. The model takes into account the mutliple…
Emma Camacho, Yuemei Dong, Christine Chrissian, Radames J.B. Cordero + 16 more
L-3,4-dihydroxyphenylalanine (L-DOPA), a naturally occurring tyrosine derivative, is prevalent in environments that include mosquito habitats, potentially serving as part of their diet. Given its role as a precursor for melanin synthesis we investigated the effect of dietary L-DOPA on mosquito physiology and immunity…
Divine Wanduku
A comparative stochastic and deterministic study of a family of SEIRS epidemic dynamic models for malaria is presented. The family type is determined by the qualitative behavior of the nonlinear incidence rates of the disease. Furthermore, the malaria models exhibit three random delays:- two of the delays represent the…
Jacqueline Wahura Waweru, Nicola Mulder, Cynthia Nyambura King’ori, Irene Muiruri + 6 more
Microsporidia MB is an endosymbiotic microbe found in Anopheles mosquito populations. This symbiont can block Plasmodium transmission in mosquitoes, and it can spread through mosquito populations and be sustained over generations by vertical and horizontal transmission. These characteristics make Microsporidia MB a…
B. Buonomo
A malaria model is formulated which includes the enhanced attractiveness of infectious humans to mosquitoes, as result of host manipulation by malaria parasite, and the human behavior, represented by insecticide-treated bed nets usage. The occurrence of a backward bifurcation at R0 = 1 is shown to be possible, which…
Kaushik Zaman Dipto, Raiyan Shariar, Chinmoy Kumar Saha, Abir Huzaifa + 9 more
Malaria, caused by the Plasmodium falciparum, remains a significant global health challenge, with Plasmodium falciparum accounting for approximately 50% of cases and posing a considerable threat. Despite advances in control measures, malaria continues to cause an estimated one million deaths annually. The complex…
Chinedu Ogbonnia Egwu, Chinyere Aloke, Jennifer Chukwu, Anthony Agwu + 5 more
'Esther Alum' 'Ioannis Tsamesidis' 'Patrick M Aja' 'Christian E Offor' 'Nwogo Ajuka Obasi'] The global burden of malaria seems unabated. Africa carries the greatest burden accounting for over 95% of the annual cases of malaria. For the vision of a world free of malaria by Global Technical Strategy to be achieved…
Jacob B. Aguilar, Juan B. Gutiérrez
Asymptomatic individuals in the context of malarial disease refers to subjects who carry a parasite load but do not show clinical symptoms. A correct understanding of the influence of asymptomatic individuals on transmission dynamics will provide a comprehensive description of the complex interplay between the…
Ramsès Djidjou‐Demasse, Arnaud Ducrot, Nicole Mideo, Gaëtan Texier
Many models of within-host malaria infection dynamics have been formulated since the pioneering work of Anderson et al. in 1989. Biologically, the goal of these models is to understand what governs the severity of infections, the patterns of infectiousness, and the variation thereof across individual hosts.…
Andrew Jamieson, Skye Brettell, Omar Jahna, Abbey Begen + 11 more
Malaria continues to pose a significant global health threat, with the number of deaths exceeding 600,000 annually. Acquired resistance to frontline drugs by the most deadly parasite, Plasmodium falciparum, means this number is increasing each year. There is therefore an urgent unmet need for new medicines with novel…
wenzhong liu, hualan li
Malaria symptoms are very similar to those of COVID-19, and infections can be symptomatic or asymptomatic. Common immunodominant epitopes are shared by the SARS-CoV-2 proteins and the Plasmodium falciparum antigen. Through bioinformatics methods such as domain search, this study discovered that the S, ORF3a proteins…
Authors not listed
Mosquito-borne diseases cause major public health challenges worldwide. There is a need for effective yet sustainable mosquito control methods as alternatives to synthetic repellents. This study evaluated the mosquito repellent potential of Ocimum tenuiflorum L. subtypes Krishna and Rama and O. gratissimum L. essential…
Authors not listed
In this study, we investigated the antiplasmodial properties of a series of fluorinated peptoid-capped histone deacetylase inhibitors (HDACi) against asexual blood stages of the drug-sensitive 3D7 and drug-resistant Dd2 strains of Plasmodium falciparum, as well as the exo-erythrocytic liver stages and mature…
Md Nurul Anwar, James M. McCaw, Alexander E. Zarebski, Roslyn I. Hickson + 1 more
'Roslyn I. Hickson' 'Jennifer A. Flegg'] Plasmodium vivax is the most geographically widespread malaria parasite due to its ability to remain dormant (as a hypnozoite) in the human liver and subsequently reactivate. Given the majority of P. vivax infections are due to hypnozoite reactivation, targeting the hypnozoite…
Authors not listed
Malaria remains a critical global health challenge, with increasing resistance to frontline therapies necessitating novel drug targets. The proteasome has emerged as a promising target for antimalarial drug discovery. This study describes efforts to optimize a series of species-selective reversible inhibitors targeting…
Authors not listed
Plasmodium falciparum, the deadliest causative agent of malaria, continues to evade eradication efforts through widespread drug resistance. The recent development of ADC-028, a 4-aminoquinoline antimalarial with excellent activity and pharmacokinetic properties, prompted the investigation of bisquinoline analogs…