24 papers · ranked by Valyu relevance
Authors not listed
Understanding structure-mechanical activity relationships (SMARs) in polymer mechanochemistry is essential for the rational design of mechanophores with desired properties, yet SMARs in noncovalent mechanical transformations remain relatively underexplored. In this study, we designed a subset of diarylethene…
Maria Oorloff, Adam Hruby, Maxim Averbukh, Athena Alcala + 14 more
Mechanical stress is a measure of internal resistance exhibited by a body or material when external forces, such as compression, tension, bending, etc. are applied. The study of mechanical stress on health and aging is a continuously growing field, as major changes to the extracellular matrix and cell-to-cell adhesions…
Adrienne K. Scott, Michael Rafuse, Corey P. Neu
Phenotypic plasticity, or adaptability, of a cell determines its ability to survive and function within changing cellular environments. Changes in the mechanical environment, ranging from stiffness of the extracellular matrix (ECM) to physical stress such as tension, compression, and shear, are critical environmental…
Authors not listed
Mechanochromic luminescent (MCL) materials have attracted growing attention owing to their potential applications in sensing, display, and security technologies. Although crystalline MCL materials have been the most intensively investigated, quantitative evaluation of their mechanical-stimuli-responsiveness remains…
Jia Wen Nicole Lee, Yixuan Li, Xu Gao, Avery Rui Sun + 3 more
When migratory cells move from one stiffness niche to another in vivo, they are exposed to highly confined spaces imposed by dense extracellular matrix (ECM) networks and inter-tissue boundaries. Cells that originate from one niche possess distinct mechanosensitive adaptations that influence their response to their new…
Rong Cao, Huimin Tian, Yan Tian, Xianghui Fu
Mechanotransduction is a strictly regulated process whereby mechanical stimuli, including mechanical forces and properties, are sensed and translated into biochemical signals. Increasing data demonstrate that mechanotransduction is crucial for regulating macroscopic and microscopic dynamics and functionalities.…
Eiji Matsumoto, Shinji Deguchi
Mechanical adaptation underlies mechanical homeostasis by allowing living systems to restore characteristic mechanical variables under sustained perturbations. Across biological scales, turnover-mediated remodeling enables mechanical adaptation by continuously renewing internal structures under load. Despite extensive…
Daniela Nogueira Rocha, Eva Daniela Carvalho, João Bettencourt Relvas, Maria José Oliveira + 1 more
'Maria José Oliveira' 'Ana Paula Pêgo'] Cells are continuously exposed to physical forces and the central nervous system (CNS) is no exception. Cells dynamically adapt their behavior and remodel the surrounding environment in response to forces. The importance of mechanotransduction in the CNS is illustrated by…
Authors not listed
A glassy polymer containing a supramolecular mechanophore capable of responding to mechanical deformation is reported. The supramolecular mechanophore LOOP, which comprises two perylene diimide (PDI) connected by a flexible linker, was functionalized with an atom transfer radical polymerization initiator, allowing…
Vina D. L. Putra, Min Jae Song, Sarah McBride-Gagyi, Hana Chang + 5 more
Mechanomics represents the natural progression of knowledge at the intersection of mechanics and biology with the aim to codify the role of mechanical environment on biological adaptation. Compared to the mapping of the human genome, the challenge of mapping the mechanome remains unsolved. Solving this grand challenge…
Allegra Coppini, Alessandro Falconieri, Oz Mualem, Syeda Rubaiya Nasrin + 6 more
'Syeda Rubaiya Nasrin' 'Marine Roudon' 'Gadiel Saper' 'Henry Hess' 'Akira Kakugo' 'Vittoria Raffa' 'Orit Shefi'] Biological structures have evolved to very efficiently generate, transmit, and withstand mechanical forces. These biological examples have inspired mechanical engineers for centuries and led to the…
Pawel R. Golyski, Gregory S. Sawicki
Maintaining stability during perturbed locomotion requires coordinated responses across multiple levels of organization (e.g., legs, joints, muscle-tendon units). However, current approaches to investigating such responses lack a “common currency” that is both shared across scales and can be directly related to…
Authors not listed
Shaping supramolecular hydrogels formed using low molecular weight gelators (LMWGs) into architecturally complex and multifunctional materials is a significant challenge. Here, we introduce a strategy to mechanically twist multiple 1D supramolecular gel filaments (gel noodles) into robust, multifunctional, and…
Marcos Latorre, Jay D. Humphrey
Constrained mixture models of soft tissue growth and remodeling can simulate many evolving conditions in health as well as in disease and its treatment, but they can be computationally expensive. In this paper, we derive a new fast, robust finite element implementation based on a concept of mechanobiological…
Authors not listed
In all-solid-state batteries (ASSBs), the mechanical stress generated during electrode (de)lithiation plays a critical role in determining the cell longevity because of the induced degradation mechanisms. This stress originates from local volume fluctuations in the active electrode materials, which are intrinsically…
Carotenuto, Angelo Rosario, Palumbo, Stefania + 4 more
Morphoelasticity represents a foundational theory for tracing back growth, remodelling, and morphogenesis, yet crucial challenges persist. A unified growth law —independent of a priori assumptions about constitutive relations or specified structures of the growth tensor— remains in fact elusive, as does an intimate…
Tarannom Parhizkar, Theresa Stewart, Lixian Huang, Ali Mosleh
A cyber physical human complex system failure prevents the accomplishment of the system's intended function. The failure of a complex system could be a breakdown of any system hardware, human related factors, application software, or the interaction between these components. Having knowledge about all these three…
Suraj Reddy
Materials with special geometrically designed microstructures, referred to as metamaterials, have gained significant attention in the world due to their unique properties of toughness and failureresistance. The ability to simply alter the internal geometry of almost any material to exponentially increase strength is…
Agnieszka Kowalik, Patrycja Paszenda, Julia Rydzek, Małgorzata Stanios + 3 more
Mechanobiology has emerged as a unifying framework for understanding how mechanical forces and tissue physical properties regulate cellular function, metabolism, and disease progression. Mechanical forces are fundamental regulators of cellular behaviour and tissue homeostasis. Growing evidence indicates that…
Joy Kim, Sarah Sterman, Allegra A. Beal Cohen, Michael S. Bernstein
Crowdsourcing systems accomplish large tasks with scale and speed by breaking work down into independent parts. However, many types of complex creative work, such as fiction writing, have remained out of reach for crowds because work is tightly interdependent: changing one part of a story may trigger changes to the…
Emma Lejeune, Peerasait Prachaseree
From healing wounds to maintaining homeostasis in cyclically loaded tissue, living systems have a phenomenal ability to sense, store, and respond to mechanical stimuli. Broadly speaking, there is significant interest in designing engineered systems to recapitulate this incredible functionality. In engineered systems…
Chandralekha Singh, Christian D. Schunn
This paper describes three conceptual areas in physics that are particularly important targets for educational interventions in K-12 science. These conceptual areas are force and motion, conservation of energy, and geometrical optics, which were prominent in the US national and four US state standards that we examined.…
Luise Pfalz, Carl Müller, Karl Kopiske
Humans adjust their motor actions to correct for errors both with and without being aware of doing so. Little is known, however, about what makes errors detectable for the actor. Here, we replicate and extend prior work showing that motor adjustments may mask the very errors they correct for. We also investigated…
Youness Hadouch, Daoud Mezzane, M barek Amjoud, Hana Ursic + 5 more
'Abdelilah Lahmar' 'Brigita Rozic' 'Igor Lukyanchuk' 'Zdravko Kutnjak' 'Mimoun El Marssi'] Magnetoelectric composites integrate the coupling between magnetic and piezoelectric materials to create new functionalities for potential technological applications. This coupling is typically achieved through the exchange of…