16 papers · ranked by Valyu relevance
Yanze Wei, Decai Zhao, Dan Wang
The prevalence of mesoscale complexity in materials science underscores the significance of the compromise in competition principle, which gives rise to the emergence of mesoscience. This principle offers valuable insights into understanding the formation process, characteristics, and performance of complex material…
Ying Ren, Ai‐Guo Wu, Yu Shi, Yi‐Fang Ping + 2 more
One of the greatest challenges in bioscience is to gain a unified view of the human immune system. This paper presents a perspective on the multilevel and multiscale complexities inherent in the immune system and discusses how these features influence the traditional research methodologies rooted in reductionism and…
Raffaella Ocone
The paper “Challenges in Immune System: Mesoscale and mesoregime complexity” by Ren et al. represents more than an important advance in immunology; it offers a growing recognition of mesoscience as a unifying scientific framework for understanding complexity. By applying the mesoscience approach to the immune system…
Jinghai Li, Wenlai Huang, Peter P. Edwards, Mooson Kwauk + 2 more
'J. T. Houghton' 'Daniel R. Slocombe'] The universality of mesoscales, ranging between elemental particles and the universe, is discussed here by reviewing widely disparate fields and presenting four cases, at differing hierarchical levels, from chemistry, chemical engineering, meteorology, through to astronomy. An…
Jinghai Li, Wenlai Huang, Jianhua Chen, Wei Ge + 1 more
The energy-minimization multiscale (EMMS) principle of compromise in competition is believed to be generally applicable for all mesoscale problems at different levels in the real world, spanning from elementary particles to the universe. This stimulated a fundamental proposition of the concept of mesoscience. This…
Yige Liu, Bidan Zhao, Junwu Wang
Quantification of the spatiotemporal dynamics of heterogeneous gas-solid flows is critical for the design, scale-up and optimization of gas-solid reactors. In this article, by using the core concept of mesoscience (the compromise in competition between dominant mechanisms), a mathematically rigorous procedure is…
Jinghai Li, Wenlai Huang
In recent years, the paradigm shift in science has become a hot topic in the global scientific community. Scientific problems unsolved with existing know-ledge or through traditional approaches can be found in all disciplines. On the other hand, more effective ways to meet global challenges, such as climate change…
Lauren M. Lui, Erica L.-W. Majumder, Heidi J. Smith, Hans K. Carlson + 8 more
Over the last century, leaps in technology for imaging, sampling, detection, high-throughput sequencing, and -omics analyses have revolutionized microbial ecology to enable rapid acquisition of extensive datasets for microbial communities across the ever-increasing temporal and spatial scales. The present challenge is…
Yolanda F. Wiersma, Rachel D. Wigle, R. Troy McMullin
Microcosms such as pitcher plants, or patches of mosses on a rock surface, have been used worldwide to allow for manipulative experiments that test hypotheses for patterns observed at larger extents, such as dispersal or community assemblage. Such microcosms can also be applied to questions in landscape ecology, but…
Yaneer Bar‐Yam
Advances in science are being sought in newly available opportunities to collect massive quantities of data about complex systems. While key advances are being made in detailed mapping of systems, how to relate this data to solving many of the challenges facing humanity is unclear. The questions we often wish to…
Alberto Pascual-García, Sebastian Bonhoeffer, Thomas Bell
Recent theory and experiments have reported a reproducible tendency for the coexistence of microbial species under controlled environmental conditions. This observation has been explained in the context of competition for resources and metabolic complementarity given that, in microbial communities, many excreted…
Authors not listed
Understanding how plants respond to dynamic and spatially variable stimuli is a key goal in plant sciences. Traditional imaging methods often involve a trade-off between environmental control and spatial resolution, limiting their ability to capture real-time responses in high resolution. Microfluidic technology…
Aldrik H. Velders, Lisette van Lieshout, Erik A. T. Brienen, Benedict Diederich + 1 more
Microparticles are ubiquitous and span from living matter to microplastics to inorganic materials. Their detection and identification must be more accessible and time efficient. Microfluidic devices can filter microparticles from liquids, but fabricating microfluidics with lateral resolutions of a few tens of microns…
Authors not listed
The Single-probe is a multifunctional device that can be coupled to mass spectrometry (MS) for molecular analysis of microscale samples, such as single cells, tissue slices, and multicellular spheroids, under ambient conditions. In Single-probe single cell MS (SCMS) studies, this technique leverages direct sampling and…
Jeffrey Marlow, Rachel Spietz, Keun-Young Kim, Mark Ellisman + 2 more
Coastal salt marshes are key sites of biogeochemical cycling and ideal systems in which to investigate the community structure of complex microbial communities. Here, we clarify structural-functional relationships among microorganisms and their mineralogical environment, revealing previously undescribed metabolic…
Authors not listed
Desorption Electrospray Ionization Mass Spectrometry Imaging (DESI-MSI) is a powerful technique for molecular analysis of surfaces; however, its application of single cell studies has not been previously published. In the current work, a commercial DESI setup (DESI XS) coupled to a mass spectrometer was used to analyze…