25 papers · ranked by Valyu relevance
Reuben L Smith, Maarten R Soeters, Rob C I Wüst, Riekelt H Houtkooper
'Riekelt H Houtkooper'] Title: Abstract The ability to efficiently adapt metabolism by substrate sensing, trafficking, storage, and utilization, dependent on availability and requirement, is known as metabolic flexibility. In this review, we discuss the breadth and depth of metabolic flexibility and its impact on…
Xin Du, Yisi Hu, Guangping Huang, Fuwen Wei
Metabolism is the basis for sustaining life and essential to the adaptive evolution of organisms. With the development of high-throughput sequencing technology, genetic mechanisms of adaptive evolution, including metabolic adaptation, have been extensively resolved by omics approaches, but a deep understanding of…
Douglas L. Rothman, Peter B. Moore, Robert G. Shulman
Since Jacob and Monod’s discovery of the lac operon ∼1960, the explanations offered for most metabolic adaptations have been genetic. The focus has been on the adaptive changes in gene expression that occur, which are often referred to as “metabolic reprogramming.” The contributions metabolism makes to adaptation have…
Ayush D. Midha, Yuyin Zhou, Bruno B. Queliconi, Alec M. Barrios + 5 more
Oxygen deprivation can be detrimental. However, chronic hypoxia is associated with decreased incidence of metabolic syndrome and cardiovascular disease in high-altitude populations. Previously, hypoxic fuel rewiring has primarily been studied in immortalized cells. Here, we describe how systemic hypoxia rewires fuel…
Braulio A. Assis, Isabella J. Burger, Savannah J. Weaver, Karey E. Duvall + 1 more
Understanding the mechanisms that shape species’ geographic distributions is essential for predicting responses to climate change, particularly under winter conditions, which are warming more rapidly than summer conditions in many temperate ecosystems. Woodland salamanders, which constitute many of the species in the…
Andrés Mesas, Luis E. Castañeda
Adaptations to warming conditions exhibited by ectotherms include increasing heat tolerance but also metabolic changes to reduce maintenance costs (metabolic depression), which can allow them to redistribute the energy surplus to biological functions close to fitness. Currently, there is evidence that energy metabolism…
Oriol Güell, Francesc Sagués, M. Ángeles Serrano
The heterogeneity of reaction fluxes present in a metabolic network within a single flux state can be exploited to construct the so-called backbone as a reduced version of metabolism. The backbone maintains all significant fluxes producing or consuming metabolites while displaying a substantially decreased number of…
Jun Zhong, Jian Chen, Yu-Hong Lu, Yu-Fei Huang + 8 more
'Xiang Ji' 'Yiannis G. Zevgolis' 'Triantaphyllos Akriotis' 'Anastasia Christopoulou' 'Panayiotis G. Dimitrakopoulos' 'Dimitra-Lida Rammou' 'Dionisios Youlatos'] Title: Simple Summary The adaptation of organisms to high altitudes has always been a key concern. Here, we investigated high-altitude adaptation in the…
Wolfram Liebermeister
Periodic enzyme activities can improve the metabolic performance of cells. As an adaptation to periodic environments or by driving metabolic cycles that can shift fluxes and rearrange metabolic processes in time to increase their efficiency. To study what benefits can ensue from rhythmic gene expression or…
David L. Swanson, Maria Stager, François Vézina, Jin-Song Liu + 2 more
'Andrew E. McKechnie' 'Reza Goljani Amirkhiz'] Reversible phenotypic flexibility allows organisms to better match phenotypes to prevailing environmental conditions and may produce fitness benefits. Costs and constraints of phenotypic flexibility may limit the capacity for flexible responses but are not well understood…
Katie Fan
Metabolic engineering in plants has emerged as a powerful approach to address global challenges in agriculture, nutrition, and sustainability. This comprehensive review explores cutting-edge strategies for manipulating primary and secondary metabolic pathways in plants, utilizing advanced genetic modification tools to…
Amanda K. Pettersen, Neil B. Metcalfe
4. ## Is variation in metabolic rate adaptive? …I am convinced that Natural Selection has been the most important, but not the exclusive, means of modification (Darwin 1872 [62, p. 22]) A key question that has emerged from measures of metabolic rates, is whether variation in metabolism is related to fitness . Lande &…
Yu Fan, WeiWei Guo, LiXin Yang, HaiQi Xu
High-altitude environments impose substantial metabolic constraints on human physiology, with oxygen limitation driving profound alterations in lipid regulation. This narrative review synthesizes current evidence on the context-dependent effects of high-altitude hypoxia (HAH) on systemic lipid metabolism across…
Elisa Thoral, Carmen C. García Díaz, Elin Persson, Imen Chamkha + 3 more
Although mitochondrial respiration is believed to explain a substantial part of the variation in whole-animal basal (BMR) or resting metabolic rate (RMR), few studies have addressed the relationship between organismal and cellular metabolism and how this may vary in environments where individual demands for energy…
Lin Su, Santiago Rodriguez Jimenez, Marion Short, Erwin Reisner
We report the adaptive laboratory evolution (ALE) of Clostridium ljungdahlii (Cl) for enhanced syngas fermentation, enabling its integration into a photocatalytic CO₂-to-syngas conversion system for the upcycling of CO₂ to C₂ products, acetate and ethanol. The adapted strain, Cladapt, exhibits a 2.5-fold increase in…
Andrew Goetz, Laurence Morel, Purushottam Dixit
Impaired metabolism is recognized as an important contributor to pathogenicity of T cells in Systemic Lupus Erythematosus (SLE). Over the last two decades, we have acquired significant knowledge about the signaling and transcriptomic programs related to metabolic rewiring in healthy and SLE T cells. However, our…
Omera B. Matoo, Cole R. Julick, Kristi L. Montooth
Organismal physiology emerges from metabolic pathways and structures that can vary across development and among individuals. Here we tested whether genetic variation at one level of physiology can be buffered at higher levels during development by the inherent capacity for homeostasis in physiological systems. We found…
Charlotte E. Bopp, Nora M. Bernet, Fabian Meyer, Riyaz Khan + 4 more
Oxygenation of aromatic and aliphatic hydrocarbons by Rieske oxygenases is the initial step of various biodegradation pathways for environmental organic contaminants. Microorganisms carrying Rieske oxygenases are able to quickly adapt their substrate spectrum to alternative carbon and energy sources that are…
Shaohua Guan, Zhichao Zhang, Zihan Zhang, Hualin Shi
The metabolic network plays a crucial role in regulating bacterial metabolism and growth, but it is subject to inherent molecular stochasticity. Previous studies have utilized flux balance analysis and the maximum entropy method to predict metabolic fluxes and growth rates, while the underlying principles governing…
Yuri K. Shestopaloff
Energy production is a very foundation of life as such. In living organisms, the rate of produced energy (E) is measured as amount of energy produced per unit of time (J s-1), and sometimes, in addition, per unit of mass (J s-1 kg-1). In many instances, dependence of rate of produced energy from mass of an organism M…
Philip M.M. Ruppert, Aylin S. Güller, Marcus Rosendal, Natasa Stanic + 1 more
About 1 billion people are living with obesity worldwide. GLP-1-based drugs have massively transformed care, but long-term consequences are unclear in part due to reductions in energy expenditure with ongoing use. Diet-induced thermogenesis (DIT) and cold exposure (CE) raise EE via brown adipose tissue (BAT) activation…
Giovanna De Palo, Robert G. Endres
Eukaryotic adaptation pathways operate within wide-ranging environmental conditions without stimulus saturation. Despite numerous differences in the adaptation mechanisms employed by bacteria and eukaryotes, all require energy consumption. Here, we present two minimal models showing that expenditure of energy by the…
Matthew Lewis, Elena Chekmeneva, Stephane Camuzeaux, Caroline Sands + 11 more
Metabolomics utilising liquid chromatography mass spectrometry (LC-MS) offers biomedical researchers a powerful means of assessing and comparing human phenotypes via measurement of the metabolome in biological samples. Platforms for LC-MS-based global profiling quantify hundreds or thousands of small molecule…
Yuuki Matsushita, Kunihiko Kaneko
Living systems adapt to various environmental conditions by changing their internal states. Inspired by gene expression and epigenetic modification dynamics, we herein propose a generic mechanism for adaptation by combining fast oscillatory dynamics and a slower feedback fixation process. Through extensive model…
Authors not listed
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by progressive cognitive decline and widespread neurovascular disturbances. Traditional fMRI provides valuable spatial maps of blood-oxygen-level-dependent (BOLD) changes but often lacks the capacity to quantify the interplay of cerebral blood flow…