27 papers · ranked by Valyu relevance
Jan Stenvang, Andreas Petri, Morten Lindow, Susanna Obad + 1 more
'Sakari Kauppinen'] MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene expression in many developmental and cellular processes. Moreover, there is now ample evidence that perturbations in the levels of individual or entire families of miRNAs are strongly associated with the…
Eva van Rooij, Sakari Kauppinen
MicroRNAs (miRNAs) play key regulatory roles in diverse biological processes and are frequently dysregulated in human diseases. Thus, miRNAs have emerged as a class of promising targets for therapeutic intervention. Here, we describe the current strategies for therapeutic modulation of miRNAs and provide an update on…
Paulina Galka-Marciniak, Martyna Olga Urbanek-Trzeciak, Daniel Kuznicki, Natalia Szostak + 18 more
There is a growing interest in the genetic variation of noncoding genomic elements, including miRNAs, and several mutations in miRNA genes implicated in human diseases, including cancer, have already been detected. However, the lack of dedicated analytical tools severely hampers progress in this area. In this study, we…
Parag P Shah, Lauren E Hutchinson, Sham S Kakar
MicroRNAs (miRNAs) represent a class of small non-coding RNAs that control gene expression by targeting messenger RNA (mRNA). Recently, it has been demonstrated that miRNA expression is altered in many human diseases including cancers, suggesting that miRNA may play a potential role in the pathogenesis of different…
Masahiro Horita, Colin Farquharson, Louise A Stephen
MicroRNAs are small noncoding RNAs that can bind to the target sites in the 3’-untranslated region of messenger RNA to regulate posttranscriptional gene expression. Increasing evidence has identified the miR-29 family, consisting of miR-29a, miR-29b-1, miR-29b-2, and miR-29c, as key regulators of a number of biological…
Per Hydbring, Gayane Badalian-Very
MicroRNAs represent a class of small RNAs derived from polymerase II controlled transcriptional regions. The primary transcript forms one or several bulging double stranded hairpins which are processed by Drosha and Dicer into hetero-duplexes. The targeting microRNA strand of the duplex is incorporated into the RNA…
Gioacchino P. Marceca, Rosario Distefano, Luisa Tomasello, Alessandro Lagana’ + 10 more
MicroRNAs (miRNAs) are a class of regulatory small non-coding RNAs that modulate gene expression. As such, miRNAs are indirectly involved in most cellular mechanisms, including cell differentiation, proliferation, survival, and homeostasis. Several different mechanisms finely regulate miRNA expression levels and…
Thomas Desvignes, Phillipe Loher, Karen Eilbeck, Jeffery Ma + 16 more
MicroRNAs (miRNAs) are small RNA molecules (∼22 nucleotide long) involved in post-transcriptional gene regulation. Advances in high-throughput sequencing technologies led to the discovery of isomiRs, which are miRNA sequence variants. While many miRNA-seq analysis tools exist, a lack of consensus on miRNA/isomiR…
Botao Zhao, Chunsun Fan
MicroRNAs (miRNAs) are a class of non-coding small RNAs that function in almost every known cellular activity. MiRNAs play an important role in gene regulation that controls embryonic stem cell (ESC) pluripotency and differentiation, as well as induced pluripotent stem cell (iPSC) reprogramming. In this study, we…
Daniel Stribling, Yi Lei, Casey M. Guardia, Lu Li + 5 more
MicroRNAs (miRNAs) are small noncoding RNAs that function as critical post-transcriptional regulators in various biological processes. While most miRNAs are generated from processing of long primary transcripts via sequential Drosha and Dicer cleavage, some miRNAs that bypass Drosha cleavage can be transcribed as part…
Dimpal A. Nyayanit, Chetan Gadgil
MicroRNAs are small non-coding nucleotide sequences that regulate target protein expression at post-transcriptional levels. Biogenesis of microRNA is a highly regulated multi-step pathway. Regulation of miRNA biogenesis can be caused directly by the components of the biogenesis pathway or indirectly by other…
Ye Duan, Tomer Segev, Isana Veksler-Lublinsky, Victor Ambros + 1 more
The acoel worm Hofstenia miamia (H. miamia) has recently emerged as a model organism for studying whole-body regeneration and embryonic development. Previous studies suggest that post-transcriptional mechanisms likely play important roles in whole-body regeneration. Here, we establish a resource for studying H. miamia…
Wang Qi, Wei Guan
MicroRNA-206 (miR-206) is a microRNA that is involved in many human diseases, such as myasthenia gravis, osteoarthritis, depression, cancers, etc. Both inhibition effects and progression roles of miR-206 have been reported for the past few years. High expression of miR-206 was observed in patients with osteoarthritis…
Shelly Mahlab-Aviv, Keren Zohar, Yael Cohen, Ayelet R. Peretz + 3 more
MicroRNAs (miRNAs) act as negative regulators of gene expression in the cytoplasm. Previous studies identified miRNAs associated with the spliceosome. Here we study three breast-derived cell-lines with increased tumorigenicity (from MCF-10A to MCF-7 and MDA-MB-231) and compared their miRNA sequences at the spliceosome…
Simone Aureli, Francesco Bellina, Valerio Rizzi, Francesco Luigi Gervasio
MicroRNAs (miRNAs) are short, non-coding RNA strands that regulate the activity of messenger RNAs (mRNAs) by affecting the repression of protein translation, and their dysregulation has been implicated in several pathologies. miR21 in particular has been implicated in tumourigenesis and anticancer drug resistance…
Xiao‐Jun Tian, Hang Zhang, Jingyu Zhang, Jianhua Xing
miRNAs serve as crucial post-transcriptional regulators in various essential cell fate decision. However, the contribution of the mRNA-miRNA mutual regulation to bistability is not fully understood. Here, we built a set of mathematical models of mRNA-miRNA interactions and systematically analyzed the sensitivity of…
Jaya Thomas, Lee Sael
—MicroRNA (miRNA) are small non-coding RNAs that regulates the gene expression at the post-transcriptional level. Determining whether a sequence segment is miRNA is experimentally challenging. Also, experimental results are sensitive to the experimental environment. These limitations inspire the development of…
Andreï Zinovyev, Nadya Morozova, Alexander N. Gorban, Annick Harel-Belan
'Annick Harel-Belan'] MicroRNAs can affect the protein translation using nine mechanistically different mechanisms, including repression of initiation and degradation of the transcript. There is a hot debate in the current literature about which mechanism and in which situations has a dominant role in living cells. The…
Janet Sasso, Barbara Ambrose, Rumiana Tenchov, Ruchira Datta + 3 more
In the last decade, there has been a shift in research, clinical development, and commercial activity to exploit the many roles of RNA in physiology for use in medicine. With the rapid success in the development of lipid-RNA nanoparticles for mRNA vaccines against COVID-19 and with several approved RNA-based drugs, RNA…
Mingjun Zhong, Rong Liu, Bo Liu
MicroRNAs (miRNAs) are small RNA molecules composed of 19–22 nt, which play important regulatory roles in post-transcriptional gene regulation by inhibiting the translation of the mRNA into proteins or otherwise cleaving the target mRNA. Inferring miRNA targets provides useful information for understanding the roles of…
B Diosdado, M A van de Wiel, J S Terhaar Sive Droste, S Mongera + 4 more
'C Postma' 'W J H J Meijerink' 'B Carvalho' 'G A Meijer'] Background: MicroRNAs are small non-coding RNA molecules, which regulate central mechanisms of tumorigenesis. In colorectal tumours, the combination of gain of 8q and 13q is one of the major factors associated with colorectal adenoma to adenocarcinoma…
Aarav Arora, Igor Tsigelny, Valentina Kouznetsova
Purpose Laryngeal cancer (LC) is the most common head and neck cancer, which often goes undiagnosed due to the expensiveness and inaccessible nature of current diagnosis methods. Many recent studies have shown that microRNAs (miRNAs) are crucial biomarkers for a variety of cancers. Methods In this study, we create a…
Alessandro Luigi Sellerio, Emilio Ciusani, Noa Bossel Ben‐Moshe, Stefania Coco + 6 more
'Stefania Coco' 'A. Piccinini' 'Christopher R. Myers' 'James P. Sethna' 'Costanza Giampietro' 'Stefano Zapperi' 'Caterina A. M. La Porta'] The dynamics of tumor cell populations is hotly debated: do populations derive hierarchically from a subpopulation of cancer stem cells (CSCs), or are stochastic transitions that…
Abderrahim Chafik
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally. They are involved in key biological processes and then may play a major role in the development of human diseases including cancer, in particular their involvement in breast cancer metastasis has been confirmed. Recently…
Hafeez Haniff, Laurent Knerr, Xiaohui Liu, Gogce Crynen + 5 more
Vascular Endothelial Growth Factor A (VEGFA) stimulates angiogenesis in human endothelial cells and increasing its expression is a potential treatment for heart failure, currently accomplished via gene or mRNA therapy. Herein, we describe a designed small molecule (TGP-377) that specifically and potently enhances VEGFA…
Authors not listed
Locked nucleic acids (LNAs) are chemically modified oligonucleotides that play a central role in modern gene silencing strategies, particularly in precision oncology. However, their clinical application is limited by the absence of simple and rapid methods to monitor their concentration in biological fluids, which is…
Tomoya Maruyama, Jing Gong, Masahiro Takinoue
Bio-soft matter droplets formed via liquid-liquid phase separation (LLPS) of biopolymers have been found in living cells. Synthetic LLPS droplets have recently been employed in nanobiotechnology for artificial cell construction, molecular robotics, molecular computing, diagnosis, and therapeutics. Controlling the…