20 papers · ranked by Valyu relevance
Donna K. Slonim, Itai Yanai, Olga G. Troyanskaya
Gene expression microarrays provide a snapshot of all the transcriptional activity in a biological sample. Unlike most traditional molecular biology tools, which generally allow the study of a single gene or a small set of genes, microarrays facilitate the discovery of totally novel and unexpected functional roles of…
Greg Gibson
Microarrays can survey genome-wide expression patterns. Not only can these gene expression profiles be used to identify a few genes of interest, they are now being creatively applied for hypothesis generation and testing
Shirley Bikel, Leonor Jacobo-Albavera, Fausto Sánchez-Muñoz, Fernanda Cornejo-Granados + 8 more
'Fernanda Cornejo-Granados' 'Samuel Canizales-Quinteros' 'Xavier Soberón' 'Rogerio R. Sotelo-Mundo' 'Blanca E. del Río-Navarro' 'Alfredo Mendoza-Vargas' 'Filiberto Sánchez' 'Adrian Ochoa-Leyva' 'Shree Ram Singh'] Background In spite of the emergence of RNA sequencing (RNA-seq), microarrays remain in widespread use for…
Fadi Alharbi, Aleksandar Vakanski
Cancer is a term that denotes a group of diseases caused by abnormal growth of cells that can spread in different parts of the body. According to the World Health Organization (WHO), cancer is the second major cause of death after cardiovascular diseases. Gene expression can play a fundamental role in the early…
Pratik Jaluria, Konstantinos Konstantopoulos, Michael Betenbaugh, Joseph Shiloach
'Joseph Shiloach'] With advances in robotics, computational capabilities, and the fabrication of high quality glass slides coinciding with increased genomic information being available on public databases, microarray technology is increasingly being used in laboratories around the world. In fact, fields as varied as…
Eric Bair
DNA microarrays are a relatively new technology that can simultaneously measure the expression level of thousands of genes. They have become an important tool for a wide variety of biological experiments. One of the most common goals of DNA microarray experiments is to identify genes associated with biological…
Rajesh K Sharma, William E Orr, Allyson D Schmitt, Dianna A Johnson
Background Retinal pigment epithelium cells play an important role in the pathogenesis of age related macular degeneration. Their morphological, molecular and functional phenotype changes in response to various stresses. Functional profiling of genes can provide useful information about the physiological state of cells…
Rong Chen, Rohan Mallelwar, Ajit Thosar, Shivkumar Venkatasubrahmanyam + 1 more
'Shivkumar Venkatasubrahmanyam' 'Atul J Butte'] Background The amount of gene expression data in the public repositories, such as NCBI Gene Expression Omnibus (GEO) has grown exponentially, and provides a gold mine for bioinformaticians, but has not been easily accessible by biologists and clinicians. Results We…
Guy P Hunt, Rafael Henkin, Fabrizio Smeraldi, Michael R Barnes
Over the past three decades there have been numerous molecular biology developments that have led to an explosion in the number of gene expression studies being performed. Many of these gene expression studies publish their data to the public database GEO, making them freely available. By analysing gene expression…
Khalid Raza, Akhilesh Mishra
The high-throughput data generated by microarray experiments provides complete set of genes being expressed in a given cell or in an organism under particular conditions. The analysis of these enormous data has opened a new dimension for the researchers. In this paper we describe a novel algorithm to microarray data…
Khalid Raza
Microarray is one of the essential technologies used by the biologist to measure genome-wide expression levels of genes in a particular organism under some particular conditions or stimuli. As microarrays technologies have become more prevalent, the challenges of analyzing these data for getting better insight about…
S. Ashokraj, E. Edwin Raj, K.N. Chandrashekara, R. Govindaraj + 2 more
The blister blight (BB) and grey blight (GB) diseases are the major biotic stresses, which affecting the plant health, yield and quality of tea. The study aims to understand the gene response of tea plants against destructing foliar diseases in terms of differential gene expression and their pathways through microarray…
Mrutyunjaya Panda
Gene is the basic unit of storage containing hereditary information in living beings. For the technical point of view,it can be treated as a distinct sequence of nucleotides constituting part of a chromosome. Microarrays data analysis is relatively a new technology that aims to help in finding the right treatment for…
Laura Saba, Paula L. Hoffman, Cheryl Hornbaker, Sanjiv V. Bhave + 1 more
'Boris Tabakoff'] Researchers from a wide variety of backgrounds and with a broad range of goals have utilized high-throughput screening technologies (i.e., microarray technologies) to identify candidate genes that may be associated with an observable characteristic or behavior (i.e., phenotype) of interest. However…
Christopher A Mancuso, Jacob L Canfield, Deepak Singla, Arjun Krishnan
While there are >2 million publicly-available human microarray gene-expression profiles, these profiles were measured using a variety of platforms that each cover a pre-defined, limited set of genes. Therefore, key to reanalyzing and integrating this massive data collection are methods that can computationally…
Alina Frolova, Vladyslav Bondarenko, Maria Obolenska
According to major public repositories statistics an overwhelming majority of the existing and newly uploaded data originates from microarray experiments. Unfortunately, the potential of this data to bring new insights is limited by the effects of individual study-specific biases due to small number of biological…
Michael A. Bertagna, Lydia J. Bright, Fei Ye, Yu-Yang Jiang + 6 more
Although an established model organism, Tetrahymena thermophila remains comparatively inaccessible to high throughput screens, and alternative bioinformatic approaches still rely on unconnected datasets and outdated algorithms. Here, we report a new approach to consolidating RNA-seq and microarray data based on a…
Authors not listed
Large-scale de novo nucleic acid synthesis is a powerful tool enabling researchers to better understand and engineer biological systems. Fields ranging from genomics to nucleic acid therapeutics to synthetic biology make use of high-throughput experimental approaches requiring access to large pools or libraries of DNA…
Chin Hong Ooi, Nam-Trung Nguyen, Gregor Kijanka
Protein arrays are systematically arranged, large collections of annotated proteins on planar surfaces commonly used for the characterisation of protein binding events against a wide range of possible probes. These may include analyses of protein-protein, peptide-protein, enzyme-substrate or antibody-antigen…
Zahir Ali, Maged Serag, Gozde Demirer, Bruno Torre + 4 more
Efficient delivery of DNA, RNA, and genome engineering machinery to plant cells will enable efforts to genetically modify plants for global food security, sustainable energy production, synthetic biology applications, and climate change resilience. For the delivery of functional genetic units into plant cells, charged…