12 papers · ranked by Valyu relevance
Li Peng, Weisi Lai, Jian Huang, Yan Zhong
Early detection of preeclampsia with noninvasive and reliable biomarkers is the foremost step for minimizing adverse effects during pregnancy. However, none maternal serum analyte evaluated so far is sufficiently accurate to allow recommending their routine use. Microarray was used to first identify differentially…
Lena Trnovec, Miha Štajdohar, Gad Shaulsky, Blaž Zupan
dictyExpress 3.0 is a React/TypeScript reimplementation of the Dictyostelium discoideum transcriptomics web server, first introduced in 2009, that unifies bulk and single-cell exploration. A long-standing gene-expression resource for the Dictyostelium community, dictyExpress is also accessible through dictyBase, the…
Meili Xi, Rongkui Luo, Jiarong Zhang, Weihong Huang + 3 more
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine-metabolic disorder characterized by profound disturbances in energy metabolism, yet the molecular mechanisms underlying glycolytic dysfunction remain incompletely understood. Given the essential role of glycolysis in ovarian function and endocrine…
Chloé A. van der Burg, Alexander Goikoetxea, Simon Muncaster, Oscar Ortega-Recalde + 8 more
Many fish undergo dramatic, socially cued female-to-male sex change, yet the events that initiate and then regulate gonadal reprogramming and reorganisation during this phenomenal metamorphosis are broadly unknown. The New Zealand spotted wrasse, Notolabrus celidotus, is a temperate fish species that displays the…
Ye Gao, Ni Wang, Zhaoyang Xiao, Alessandro Medoro
The GEOquery package (v2.74.0) was employed to retrieve datasets related to ARDS from the Gene Expression Omnibus (GEO) database ([https://www.ncbi.nlm.nih.gov/geo/]()). Specifically, the training set [GSE32707]() comprised blood samples from 58 septic patients (control group) and 31 patients with sepsis-induced ARDS…
Ru Yu, Min Gao, Lin Cai, Shuoxuan Wang + 8 more
Key message StERF87 directly activates StPR1a via GCC-box binding and integrates SA/ET signaling to enhance bacterial wilt resistance. Abstract Potato (Solanum tuberosum) is an important food crop worldwide, yet its yield is severely constrained by bacterial wilt caused by Ralstonia solanacearum. We used RNA-Seq to…
Fei-Fei Cheng, Hao Mou, Zhenyu Liu, Chang-Jun Zhang + 7 more
Title: Significance Age-related macular degeneration (AMD) is the most common cause of irreversible vision loss among older adults and is projected to affect approximately 288 million people worldwide by 2040. Identifying the genes and cellular mechanisms underlying established AMD risk loci is essential for…
Jahnavi Bhaskaran, Elizabeth Ing-Simmons, Irina Balaguer Balsells, Sara Di Persio + 11 more
Gametogenesis, the production of oocytes and sperm, ensures the faithful transmission of genetic material to the next generation. In males, spermatogenesis occurs within the testis, where germ cells progress through a highly ordered developmental programme in close association with supporting somatic cells. Defects in…
Himanshu Goel, Miklos Sahin -Toth
Alternative splicing is a major mechanism of gene regulation, affecting more than 95% of multiexonic human genes and greatly expanding transcriptomic and proteomic diversity . Through exon inclusion or exclusion, alternative splice-site selection, intron retention and mutually exclusive exon usage, individual genes can…
Eli J. Costa, Carolina Rios-Martinez, Cecelia J. Andrews, James E. Ferrell + 1 more
Quantitatively relating transcription factor (TF) input to gene expression output is central to understanding mammalian gene regulation and essential for designing predictable synthetic expression systems. However, even minimal synthetic systems often exhibit unexplained behaviors. In a widely used inducible mammalian…
Yunfei Liang, Fanyi Meng, Hongwei Sun, Hongyan Shi + 2 more
Title: SUMMARY Chilling stress severely restricts tomato cultivation and productivity, yet the mechanisms by which a single regulator integrates photosynthetic efficiency, developmental progression, and chilling tolerance remain to be elucidated. Here, we characterized SlBBX19, a chilling-inducible B-box transcription…
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes + 11 more
Gene therapies using adeno-associated viruses (AAVs) for central nervous system (CNS) disorders face challenges because host immune responses are not represented in classical preclinical models. Here, we present a human-induced pluripotent stem cell (hiPSC)-derived innate immunocompetent 3D CNS model that recapitulates…