24 papers · ranked by Valyu relevance
YiRang Shin, Matthew R. Lowerison, Yike Wang, Xi Chen + 4 more
Ultrasound localization microscopy (ULM) enables deep tissue microvascular imaging by localizing and tracking intravenously injected microbubbles circulating in the bloodstream. However, conventional localization techniques require spatially isolated microbubbles, resulting in prolonged imaging time to obtain detailed…
Xi Chen, Matthew R. Lowerison, Zhijie Dong, Aiguo Han + 1 more
Ultrasound localization microscopy (ULM) is an emerging vascular imaging technique that overcomes the resolution-penetration compromise of ultrasound imaging. Accurate and robust microbubble (MB) localization is essential for successful ULM. In this study, we present a deep learning (DL)-based localization technique…
Xi Chen, Matthew R. Lowerison, Zhijie Dong, Aiguo Han + 1 more
Ultrasound localization microscopy (ULM) is an emerging vascular imaging technique that overcomes the resolution-penetration compromise of ultrasound imaging. Accurate and robust microbubble (MB) localization is essential for successful ULM. In this study, we present a deep learning (DL)- based localization technique…
Nathan Blanken, Jelmer M. Wolterink, Hervé Delingette, Christoph Brüne + 2 more
'Christoph Brüne' 'Michel Versluis' 'Guillaume Lajoinie'] Abstract—Recently, super-resolution ultrasound imaging with ultrasound localization microscopy (ULM) has received much attention. However, ULM relies on low concentrations of microbubbles in the blood vessels, ultimately resulting in long acquisition times.…
Sepideh K. Gharamaleki, Brandon Helfield, Hassan Rivaz
—To overcome the half a wavelength resolution limitations of ultrasound imaging, microbubbles (MBs) have been utilized widely in the field. Conventional MB localization methods are limited whether by exhustive parameter tuning or considering a fixed Point Spread Function (PSF) for MBs. This questions their adaptability…
Noemi Renaudin, Sophie Pezet, Nathalie Ialy-Radio, Charlie Demene + 1 more
'Mickael Tanter'] In the last decade, Ultrafast ultrasound localisation microscopy has taken non-invasive deep vascular imaging down to the microscopic level. By imaging diluted suspensions of circulating microbubbles in the blood stream at kHz frame rate and localizing the center of their individual point spread…
YiRang Shin, Matthew R. Lowerison, Yike Wang, Xi Chen + 4 more
Ultrasound localization microscopy (ULM) is an emerging super-resolution imaging technique for deep tissue microvascular imaging. However, conventional localization methods are constrained by low microbubble (MB) concentration, as accurate localization requires a strict separation of MB point spread functions (PSFs).…
Md Ashikuzzaman, Brandon Helfield, Hassan Rivaz
Ultrasound localization microscopy (ULM) refers to a promising medical imaging modality that systematically leverages the advantages of contrast-enhanced ultrasound (CEUS) to surpass the diffraction barrier and delineate the microvascular map. Localization and tracking of microbubbles (MBs), two significant steps of…
Jihun Kim, Mathew R. Lowerison, Nathiya Chandra Sekaran, Zhengchang Kou + 4 more
Ultrasound localization microscopy (ULM) demonstrates great potential for visualization of tissue microvasculature at depth with high spatial resolution. The success of ULM heavily depends on the robust localization of isolated microbubbles (MBs), which can be challenging in vivo especially within larger vessels where…
Qi You, Joshua D. Trzasko, Matthew R. Lowerison, Xi Chen + 5 more
Ultrasound localization microscopy (ULM) based on microbubble (MB) localization was recently introduced to overcome the resolution limit of conventional ultrasound. However, ULM is currently challenged by the requirement for long data acquisition times to accumulate adequate MB events to fully reconstruct vasculature.…
Vincent Hingot, Claudia Errico, Baptiste Heiles, Line Rahal + 2 more
Medical ultrasound is a widely used diagnostic imaging technique for tissues and blood vessels. However, its spatial resolution is limited to a sub-millimeter scale. Ultrasound Localization Microscopy was recently introduced to overcome this limit and relies on subwavelength localization and tracking of microbubbles…
Hatim Belgharbi, Jonathan Porée, Rafat Damseh, Vincent Perrot + 4 more
The resolution of 3D Ultrasound Localization Microscopy (ULM) is determined by acquisition parameters such as frequency and transducer geometry but also by microbubble (MB) concentration, which is also linked to the total acquisition time needed to sample the vascular tree at different scales. In this study, we…
Ufuk Soylu, Yoram Bresler
— Ultrasound Localization Microscopy (ULM) offers a cost-effective modality for microvascular imaging by using intravascular contrast agents (microbubbles). However, ULM has a fundamental trade-off between acquisition time and spatial resolution, which makes clinical translation challenging. In this paper, in order to…
Daniil Nozdriukhin, Eva Remlova, Lin Tang, Shuxin Lyu + 6 more
'Gabriella Egri' 'Ana Torres' 'Anxo Vidal' 'Lars Dähne' 'Daniel Razansky' 'Xosé Luís Deán-Ben'] Localization optoacoustic tomography (LOT) has recently emerged as an adept imaging approach for super-resolution functional microangiography at depths out of reach for conventional optical microscopy methods. LOT enables…
David Espíndola, Ryan M. DeRuiter, Francisco Santibáñez, Paul A. Dayton + 1 more
'Paul A. Dayton' 'Gianmarco Pinton'] Abstract. Super-resolution ultrasound imaging relies on the sub-wavelength localization of microbubble contrast agents. By tracking individual microbubbles, the velocity and flow within microvessels can be estimated. It has been shown that the average flow velocity, within a…
Nareg Ohannesian, Jingting Li, Ibrahim Misbah, Fusheng Zhao + 1 more
Directed assembly and concentrating of micro- and nanoparticles via laser generated plasmonic microbubbles in a liquid environment is an emerging technology. For effective heating, visible light has been primarily employed in existing demonstrations. In this paper, we demonstrate a new plasmonic platform based on…
Hugues Favre, Mathieu Pernot, Mickaël Tanter, Clément Papadacci
Mapping blood microflows of the whole brain is crucial for early diagnosis of cerebral diseases. Ultrasound localization microscopy (ULM) was recently applied to map and quantify blood microflows in 2D in the brain of adult patients down to the micron scale. Whole brain 3D clinical ULM remains challenging due to the…
Hyungmok Joh, Bin Lian, Shaw-iong Hsueh, Zhichao Ma + 4 more
'Si-Yang Zheng' 'Peer Fischer' 'Donglei Emma Fan'] Microbubbles are an important tool due to their unique mechanical, acoustic, and dynamical properties. Yet, it remains challenging to generate microbubbles quickly in a parallel, biocompatible, and controlled manner. Here, we present an opto-electrochemical method that…
Nino Läubli, Michael Gerlt, Alexander Wüthrich, Renard Lewis + 5 more
Acoustically excited microstructures have demonstrated significant potential for small scale biomedical applications by overcoming major microfluidic limitations. Recently, the application of oscillating microbubbles has demonstrated their superiority over acoustically excited solid structures due to their enhanced…
Kai Riemer, Matthieu Toulemonde, Jipeng Yan, Marcelo Lerendegui + 4 more
'Eleanor Stride' 'Peter D. Weinberg' 'Christopher Dunsby' 'Meng‐Xing Tang'] Perfusion by the microcirculation is key to the development, maintenance and pathology of tissue. Its measurement with high spatiotemporal resolution is consequently valuable but remains a challenge in deep tissue. Ultrasound Localization…
Changsheng Chen, Hongguang Zhang, Xianren Zhang
In our previous work [Phys. Chem. Chem. Phys. 2022, 24, 9685], we show with molecular dynamics simulations that bulk nanobubbles can be stabilized by forming a compressed amphiphile monolayer at bubble interfaces. This observation closely resembles the stability origin of microemulsions and inspires us to propose here…
Jerry Chao, Taiyoon Lee, E. Sally Ward, Raimund J. Ober + 1 more
'Christof Markus Aegerter'] The localization of fluorescent microspheres is often employed for drift correction and image registration in single molecule microscopy, and is commonly carried out by fitting a point spread function to the image of the given microsphere. The mismatch between the point spread function and…
Abbas Jabermoradi, John van Duynhoven, Johannes Hohlbein
Emulsifiers play an essential role in ensuring the physiochemical stability of food emulsions. In the case of mayonnaise, proteins contained in egg yolk act as emulsifiers. Here, we employed stochastic optical reconstruction microscopy (STORM) to localize proteins at the oil/water droplet interface using fluorescently…
Koyomi Nakazawa, Antoine Lévrier, Sergii Rudiuk, Ayako Yamada + 2 more
Giant unilamellar vesicles (GUVs) are widely used minimal cell models where essential biological features can be reproduced, isolated and studied. Although precise spatio-temporal distribution of membrane domains is a process of crucial importance in living cells, it is still highly challenging to generate anisotropic…