24 papers · ranked by Valyu relevance
Elton Ho, Mark Hettick, Demetrios Papageorgiou, Adam J. Poole + 7 more
Progress toward the development of brain–computer interfaces has signaled the potential to restore, replace, or augment lost or impaired neurological function in a variety of disease states. Existing brain–computer interfaces rely on invasive surgical procedures or brain-penetrating electrodes, which limit addressable…
Giovanni Melle
Axion Biosystems and MultiChannel Systems actually represent the leader companies in the production of MEAs for in vitro high-throughput applications (Figure 13Figure 13). These platforms consists of high-throughput configurations with 12 to 96 wells. Each well may have 12 or more low noise microelectrodes with few…
Gerard O’Leary, Iouri Khramtsov, Rakshith Ramesh, Aidan Perez-Ignacio + 5 more
Bioelectronic interfaces have the potential to revolutionize the treatment of medical disorders and augment physiology. Implantable devices such as pacemakers and deep brain stimulators have already been deployed to control activity in diseases including Parkinson’s disease and epilepsy. These devices typically operate…
Geoffrey Mulberry, Kevin A. White, Brian N. Kim
In the study of the brain, large and high-density microelectrode arrays have been widely used to study the behavior of neurotransmission. CMOS technology has facilitated these devices by enabling the integration of high-performance amplifiers directly on-chip. Usually, these large arrays measure only the voltage spikes…
Pingyu Wang, Eric G. Wu, Hasan Uluşan, A.J. Phillips + 10 more
Silicon-based planar microelectronics is a powerful tool for scalably recording and modulating neural activity at high spatiotemporal resolution, but it remains challenging to target neural structures in three dimensions (3D). We present a method for directly fabricating 3D arrays of tissue-penetrating microelectrodes…
Cat-Vu H. Bui, Neethu Maliakal, Hasan Ulusan, Andreas Hierlemann + 2 more
'Fernando Cardes' 'Attila Kaszás'] Electrode designs and materials have become an increasingly important performance driver for microelectrode arrays, which are among the essential tools for cellular electrophysiology. Ongoing works have continuously innovated over a diverse range of electrode shapes, sizes, and…
Geoffrey Mulberry, Kevin A. White, Matthew A. Crocker, Brian N. Kim
In the study of the brain, large and high-density microelectrode arrays have been widely used to study the behavior of neurotransmission. CMOS technology has facilitated these devices by enabling the integration of high-performance amplifiers directly on-chip. Usually, these large arrays measure only the voltage spikes…
Alexander Erofeev, Dmitriy Kazakov, Nikita Makarevich, Anastasia Bolshakova + 8 more
Multi-electrode arrays (MEAs) are a widely used tool for recording neuronal activity both in vitro/ex vivo and in vivo experiments. In the last decade, researchers have increasingly used MEAs on rodents in vivo. To increase the availability and usability of MEAs, we have created an open-source wireless…
Authors not listed
Understanding and controlling the microstructure of zinc (Zn) metal electrodeposits is critical for advancing the next generation of rechargeable Zn batteries. In this study, we develop microelectrode arrays to systematically investigate the relationship between current density, morphology, and Coulombic efficiency…
Huiqing Zhao, Ruping Liu, Huiling Zhang, Peng Cao + 3 more
'Ye Li' 'Joseph Pancrazio'] Neural microelectrode is the important bridge of information exchange between the human body and machines. By recording and transmitting nerve signals with electrodes, people can control the external machines. At the same time, using electrodes to electrically stimulate nerve tissue, people…
Scott Greenhorn, Véronique Coizet, Victor Dupuit, Bruno Fernandez + 6 more
single units recording within subcortical layers Authors: ['Scott Greenhorn' 'Véronique Coizet' 'Victor Dupuit' 'Bruno Fernandez' 'Guillaume A. Brès' 'A. Claudel' 'Pierre Gasner' 'Jan Warnking' 'Emmanuel Barbier' 'Cécile Delacour'] Abstract. Current techniques of neuroimaging, including electrical devices, are either…
Giulia Bruno
| | Contents 3 | | --- | --- | | Summary | 5 | | 1 | Cell signalling and electrophysiology development 8 | | 1.1 | Basics of cell communication and its main components 8 | | 1.1.1 | Action potential 8 | | 1.1.2 | Neuron 9 | | 1.1.3 | Cardiomyocyte 11 | | 1.2 | History of electrophysiology and MEA development 11 | | 2 |…
Manuel Schröter, Fernando Cardes, Cat-Vu H. Bui, Lorenzo Davide Dodi + 7 more
A detailed functional characterization of electrogenic cells, such as neurons and cardiomyocytes, by means of high-density microelectrode arrays (HD-MEAs) has emerged as a powerful approach for inferring cellular phenotypes and elucidating fundamental mechanisms underlying cellular function. HD-MEAs have been applied…
Flávio Afonso Gonçalves Mourão, Leonardo de Oliveira Guarnieri, Paulo Aparecido Amaral Júnior, Vinícius Rezende Carvalho + 2 more
Electrophysiological recordings lead amongst the techniques that aim to investigate the dynamics of neural activity sampled from large neural ensembles. However, the financial costs associated with the state-of-the-art technology used to manufacture probes and multi-channel recording systems make these experiments…
Daniel P. Woods, Grace M. Adams, Rana Mozumder, Wenhao Dang + 3 more
Neurophysiological recordings from non-human primates (NHPs) have traditionally relied on rigid microelectrode arrays made from stainless steel or silicon. While these devices enable high-quality recordings, a fundamental mechanical mismatch between rigid materials and soft brain tissue leads to inflammation, gliosis…
Jo’Elen Hagler, Lucia Pizzoccaro, Meijing Wang, Guillaume Ducharme + 2 more
Brain function is governed by neural circuits distributed across an intricate, three-dimensional landscape of anatomically complex structures. Current methods for monitoring neural activity are limited to investigating structures that lie along a single, linear trajectory. While this approach is effective for columnar…
Horacio Londoño‐Ramírez, Xiaohua Huang, Jordi Cools, Anna Chrzanowska + 8 more
'Anna Chrzanowska' 'Clément Brunner' 'Marco Ballini' 'Luis Hoffman' 'Soeren Steudel' 'Cédric Rolin' 'Carolina Mora Lopez' 'Jan Genoe' 'Sebastian Haesler'] Title: Abstract Electrode grids are used in neuroscience research and clinical practice to record electrical activity from the surface of the brain. However…
Amritha Janardanan, Soner Sonmezoglu, Stefano Sonedda, Tom J. Zajdel + 5 more
Bacteria sense a diverse range of environmental analytes with high sensitivity and temporal resolution. Engineering and synthetic biology approaches enabled harnessing this capability through development of whole-cell biosensors that respond to specific molecules of interest. However, converting these responses into…
Yağmur Ceren Alataş, Uzay Tefek, Berk Küçükoğlu, Naz Bardakci + 2 more
'Sayedus Salehin' 'M. Selim Hanay'] electric field which causes the responsivity of the sensor to depend on the vertical position of a microparticle in the microfluidic channel. To overcome this problem, we fabricated three-dimensional (3D) electrodes at the coplanar sensing region of an underlying microwave resonator.…
MD Ridwan Adib, Colm Barrett, Shane O'Sullivan, Anna Flynn + 3 more
Electrochemical biosensors have been extensively researched and employed across diverse fields from environmental monitoring to clinical diagnostics. The determination of biomarkers such as glucose and pH, which are crucial for the health and well-being of animals, has led to a widespread use of these specific…
Authors not listed
Carbon fiber has become the standard electrode material to study neuronal communication. For techniques such as single-cell amperometry at synapses and intracellular recordings of neurotransmitters in secretory vesicles, nanometric electrodes are required. The smaller electrode dimension also offers the added benefit…
Steven Linfield, Sylwester Gawinkowski, Wojciech Nogala
Recently, shot noise has been shown to be an inherent part of all charge transfer processes, leading to a practical limit of quantification of 2100 electrons (~0.34 fC) (Curr. Opin. Electrochem. 2020, 22, 170177). Attainable limits of quantification are made much larger by greater background currents and insufficient…
Adva Raz, Hila Gubi, Adam Cohen, Fernando Patolsky
Biomarkers detection have become essential in medical diagnostics and early detection of life-threatening diseases. Modern-day medicine relies heavily on painful and invasive tests, the extraction of large volumes of venous blood being the most common tool of biomarker detection. These tests are time-consuming…
Yuanmo Wang, Ajay Pradhan, Pankaj Gupta, Jörg Hanrieder + 2 more
Acetylcholine (ACh) is a critical neurotransmitter influencing various neurophysiological functions. Despite its significance, there is a lack of quantitative methods with adequate spatiotemporal resolution for recording single exocytotic efflux of ACh. In this study, we present an ultrafast amperometric ACh biosensor…