27 papers · ranked by Valyu relevance
Thierry Fredrich, Heiko Rieger, Roberto Chignola, Edoardo Milotti
One of many important features of the tumour microenvironment is that it is a place of active Darwinian selection where different tumour clones become adapted to the variety of ecological niches that make up the microenvironment. These evolutionary processes turn the microenvironment into a powerful source of tumour…
Rachel Shen, Benedict Borer, Davide Ciccarese, M. Mehdi Salek + 1 more
Most microbial life on Earth is found in localized microenvironments that collectively exert a crucial role in maintaining ecosystem health and influencing global biogeochemical cycles. In many habitats such as biofilms in aquatic systems, bacterial flocs in activated sludge, periphyton mats, or particles sinking in…
Yanhui Wang, Xiaoyun Zhang, Xin Li, Min Cheng + 1 more
The vascular microenvironment comprises of anatomical structures, extracellular matrix components, and various cell populations, which play a crucial role in regulating vascular homeostasis and influencing vascular structure and function. Under physiological conditions, intrinsic regulation of the vascular…
Thierry Fredrich, Heiko Rieger, Roberto Chignola, E. Milotti
One of many important features of the tumour microenvironment is that it is a place of active Darwinian selection where different tumour clones become adapted to the variety of ecological niches that make up the microenvironment. These evolutionary processes turn the microenvironment into a powerful source of tumour…
Shunsuke A. Sakai, Ryosuke Nomura, Satoi Nagasawa, SungGi Chi + 6 more
Single-cell spatial omics analysis requires consideration of biological functions and mechanisms in a microenvironment. However, microenvironment analysis using bioinformatic methods is limited by the need to detect histological morphology. In this study, we developed SpatialKNife (SKNY), an image-processing-based…
Courtenay A. Ray, Rozalia E. Kapas, Øystein H. Opedal, Benjamin W. Blonder
Individual plants can modify the microenvironment within their spatial neighborhood. However, the consequences of microenvironment modification for demography and species interactions remain unclear at the community scale. In a study of co-occurring alpine plants, we (1) determined the extent of species-specific…
Li V. Yang
The tumor microenvironment has profound effects on cancer development, progression, and therapeutic response. Cancer cells co-exist with infiltrated immune cells, blood vessels, fibroblasts, and other stromal cells in the tumor microenvironment [1]. Deviated from their normal physiological roles, immune, vascular, and…
Jiaxi Liu, Jinfang Gao, Zixie Liang, Chong Gao + 3 more
'Fengping Wu' 'Liyun Zhang'] Mesenchymal stem cells (MSCs), coming from a wide range of sources, have multi-directional differentiation ability. MSCs play vital roles in immunomodulation, hematopoiesis and tissue repair. The microenvironment of cells often refers to the intercellular matrix, other cells, cytokines and…
Francesca Lorenzutti, Ranga Seemakurthi, Evan Johnson, Santiago Morandi + 3 more
Electrochemical CO2 reduction will be a key player in net-zero technologies, yet its industrial implementation is limited. Improvements by fine-tuning the microenvironments, electrolyte environments around the catalytic sites, have been scarce due to the interplay between electrode kinetics and transport. Here, we…
Weiguo Song, Mingli Peng, Qiqi Ma, Xiaoyu Han + 4 more
As essential skin appendages, hair follicles exhibit complex developmental and regenerative processes shaped by the skin microenvironment. Imbalances in skin microenvironmental homeostasis are often accompanied by follicle miniaturization and even hair loss. In studying the mechanisms of hair follicle development, in…
Deming Liu, Zhi-Xi Wu, Jian‐Yue Guan
Normal life activities between cells rely crucially on the homeostasis of the cellular microenvironment, but aging and cancer will upset this balance. In this paper, we introduce the microenvironmental feedback mechanism to the growth dynamics of multicellular organisms, which changes the cellular competitive ability…
Saumya Prasad, Anil Chandra, Michèle Cavo, Erika Parasido + 7 more
'Stanley T. Fricke' 'Yichien Lee' 'Eliana D’Amone' 'Giuseppe Gigli' 'Chris Albanese' 'Olga Rodríguez' 'Loretta L. del Mercato'] The tumour microenvironment strongly influences tumorigenesis and metastasis. Two of the most characterized properties of the tumour microenvironment are acidosis and hypoxia, both of which…
Jonatan A. González, Paula Moraga
The tumour microenvironment plays a fundamental role in understanding the development and progression of cancer. This paper proposes a novel spatial point process model that accounts for inhomogeneity and interaction to flexibly model a complex database of cells in the tumour immune microenvironments of a cohort of…
Jiayao Ma, Lingjuan Huang, Die Hu, Shan Zeng + 2 more
The efficacy of cancer immunotherapy largely depends on the tumor microenvironment, especially the tumor immune microenvironment. Emerging studies have claimed that microbes reside within tumor cells and immune cells, suggesting that these microbes can impact the state of the tumor immune microenvironment. For the…
Collin J. Dube, Ying Zhang, Shekhar Saha, Michelle Lai + 22 more
Glioblastoma (GBM) is the most common primary malignant brain tumor. The aim of this study was to elucidate the role of microenvironment and intrinsic T-type calcium channels (Cav3) in regulating tumor growth and progression. We grafted syngeneic GBM cells into Cav3.2 knockout mice to assess the role of…
Naji Kharouf, Thomas W. Flanagan, Sofie-Yasmin Hassan, Hosam Shalaby + 8 more
'Marla Khabaz' 'Sarah-Lilly Hassan' 'Mosaad Megahed' 'Youssef Haikel' 'Simeon Santourlidis' 'Mohamed Hassan' 'Vita Golubovskaya' 'Walter F. Bodmer'] Simple Summary As a solid tumor, melanoma is not only a tumor mass of monolithic tumor cells, but it also contains supporting stroma, extracellular matrix (ECM), and…
Authors not listed
Understanding how plants respond to dynamic and spatially variable stimuli is a key goal in plant sciences. Traditional imaging methods often involve a trade-off between environmental control and spatial resolution, limiting their ability to capture real-time responses in high resolution. Microfluidic technology…
Authors not listed
Photochemistry is at the forefront of many modern technologies, from additive manufacturing to phototherapeutics, to sun protection and organic synthesis. For centuries, it was believed that an absorbance spectrum – showing the likelihood of a photon to be absorbed by a chromophore at a given wavelength – is an…
Krisztina Nagy, Ágnes Ábrahám, Juan E. Keymer, Péter Galajda
Microfluidics is an emerging technology that is used more and more in biology experiments. Its capabilities of creating precisely controlled conditions in cellular dimensions make it ideal to explore cell-cell and cell-environment interactions. Thus, a wide spectrum of problems in microbial ecology can be studied using…
Authors not listed
Photocages have emerged as powerful tools for enabling precise control over the timing, location and quantity of the released biomolecule of interest. However, most commonly used photocages require activation by UV or violet light, which is cytotoxic. Moreover, the exclusive control of light on their photoreactivity…
Xiang-Ping Jia, Hong Sun
The fitness of somatic cells of metazoan, the ability of proliferation and survival, depends on microenvironment. In somatic evolution, a mutated cell in a tissue clonally expands abnormally because of its high fitness as normal cells in a corresponding microenvironment. In this study, we propose the cancer cell…
Yue Deng, Mingjing Li, Jinzhi Lei
Understanding how microenvironmental heterogeneity influences tumor progression is essential for advancing both cancer biology and therapeutic strategies. In this study, we develop a cellular automata (CA) model to simulate tumor growth under varying microenvironmental conditions and genetic mutation rates, addressing…
Jessica Zampolli, Alessandra De Giani, Massimiliano Rossi, Margherita Finazzi + 1 more
'Margherita Finazzi' 'Patrizia Di Gennaro'] Modern lifestyle greatly influences human well-being. Indeed, nowadays people are centered in the cities and this trend is growing with the ever-increasing population. The main habitat for modern humans is defined as the built environment (BE). The modulation of life quality…
Yao Xiao, Teng Li, Allen Rodrigo
The environment plays a crucial role in shaping the microbial composition of hosts. Different environments harbor distinct microbial communities, leading to variation in the availability of different microbes to potential hosts. Over the past few decades, human activities have significantly altered the environment…
Raphaëlle Péguilhan, Florent Rossi, Muriel Joly, Engy Nasr + 4 more
Bacteria cells and fungal spores can aerosolize and remain suspended in the atmosphere for several days, exposed to water limitation, oxidation, and lack of nutrients. Using comparative metagenomics/metatranscriptomics, we show that clouds are associated with the activation of numerous metabolic functions in airborne…
Silvia Tea Calzuola, Gwenyth Newman, Thomas Feaugas, Cécile M. Perrault + 5 more
Microfluidic devices with integrated membranes that enable control of mass transport in constrained environments have shown considerable growth over the last decade. Membranes are a key component in several industrial processes such as chemical, pharmaceutical, biotechnological, food, and metallurgy separation…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…