25 papers · ranked by Valyu relevance
Diego Gomez-Nicola, V. Hugh Perry
The study of the dynamics and functions of microglia in the healthy and diseased brain is a matter of intense scientific activity. The application of new techniques and new experimental approaches has allowed the identification of novel microglial functions and the redefinition of classic ones. In this review, we…
Nils Lannes, Elisabeth Eppler, Samar Etemad, Peter Yotovski + 1 more
'Luis Filgueira'] Microglia cells are the unique residential macrophages of the central nervous system (CNS). They have a special origin, as they derive from the embryonic yolk sac and enter the developing CNS at a very early stage. They play an important role during CNS development and adult homeostasis. They have a…
Carole Sousa, Knut Biber, Alessandro Michelucci
Microglia are essential for the development and function of the adult brain. Microglia arise from erythro-myeloid precursors in the yolk sac and populate the brain rudiment early during development. Unlike monocytes that are constantly renewed from bone marrow hematopoietic stem cells throughout life, resident…
Jinming Han, Robert A. Harris, Xing-Mei Zhang
Microglia are the principal resident immune cells in the central nervous system and are believed to be versatile players in both inflammatory and physiological contexts. On the one hand, in order to safeguard the microenvironment microglia can be rapidly activated by contact with microbial products or cell debris…
N.A. Malinovskaya, O.V. Frolova, K.O. Shishelova, Yu.A. Panina
The role and morphological features of microglia (M1 and M2 microglia, “stellate”, “amoeboid”, giant, round-shaped, rod-shaped, dysfunctional, etc.) in vivo under physiological conditions and during the development of neurodegenerative diseases have been described. Various methods and techniques of microglia isolation…
Michael Surala, Luna Soso-Zdravkovic, David Munro, Ali Rifat + 4 more
Microglia, the brain-resident macrophages, are believed to sculpt developing neural circuits by eliminating excess synapses in a process called synaptic pruning, removing apoptotic neurons, and promoting neuronal survival. To elucidate the role of microglia during embryonic and postnatal brain development, we used a…
Shashank Kumar Maurya, Suchi Gupta, Rajnikant Mishra
The emerging role of microglia in brain homeostasis, neurodegeneration, and neurodevelopmental disorders has attracted considerable interest. In addition, recent developments in microglial functions and associated pathways have shed new light on their fundamental role in the immunological surveillance of the brain.…
Timothy R. Hammond, Connor Dufort, Lasse Dissing-Olesen, Stefanie Giera + 11 more
Microglia, the resident immune cells of the brain, rapidly change states in response to their environment, but we lack molecular and functional signatures of different microglial populations. In this study, we analyzed the RNA expression patterns of more than 76,000 individual microglia during development, old age and…
Yoshie Endo, Daisuke Asanuma, Shigeyuki Namiki, Kenzo Hirose + 3 more
Microglia are resident immune cells in the central nervous system (CNS), showing a regular distribution. Advancing microscopy and image processing techniques have contributed to elucidating microglia’s morphology, dynamics, and distribution. However, the mechanism underlying the regular distribution of microglia…
Dave E. Marzan, Brian L. West, James L. Salzer
Microgliosis is a prominent pathological feature in many neurological diseases including multiple sclerosis (MS). The precise role of microglia during demyelination, and the relative contributions of microglia vs. peripheral macrophages, are incompletely understood. Here, using a genetic fate mapping strategy, we…
Daniele Lana, Giada Magni, Elisa Landucci, Gary L. Wenk + 3 more
'Domenico Edoardo Pellegrini-Giampietro' 'Maria Grazia Giovannini' 'Bruno Imbimbo'] Phenomics, the complexity of microglia phenotypes and their related functions compels the continuous study of microglia in disease animal models to find druggable targets for neurodegenerative disorders. Activation of microglia was long…
Sarah J. Meller, Lexie Hernandez, Eduardo Martin-Lopez, Teresa Liberia + 1 more
Microglia invade the neuroblast migratory corridor of the rostral migratory stream (RMS) early in development. This work examines how microglia maintain the homeostatic conditions permissive to neuroblast migration in the RMS during the early postnatal period. GFP labeled microglia in CX3CR-1^GFP/+^ mice assemble…
Chunsheng Ruan, Linlin Sun, Alexandra Kroshilina, Lien Beckers + 5 more
Microglia are resident immune cells of the central nervous system (CNS). The exact role of microglia in the physiopathology of CNS disorders is not clear due to lack of tools to discriminate between CNS resident and infiltrated innate immune cells. Here, we present a novel reporter mouse model targeting a…
Marie-France Dorion, Moein Yaqubi, Hunter J. Murdoch, Jeffery A. Hall + 4 more
Efforts to understand microglia function in health and diseases have been hindered by the lack of culture models that recapitulate in situ cellular properties. In recent years, the use of serum-free media with brain-derived growth factors (CSF1R ligands and TGF-β1/2) have been favored for the maintenance of rodent…
Gonçalo Cristovão, Maria J. Pinto, Rodrigo A. Cunha, Ramiro D. Almeida + 1 more
Microglial cells in the central nervous system (CNS) are major players of innate immunity, the first line of defense in the presence of danger signals, from bacterial infections to mediators released by neurons upon cytotoxic insult (Kettenmann et al., ). Particular attention has been paid to the involvement of…
Roobina Boghozian, Sorabh Sharma, Manjinder Cheema, Craig E. Brown
Although microglia possess the unique ability to migrate, whether mobility is evident in all microglia, is sex dependent, and what molecular mechanisms drive this, is poorly understood in the adult brain. Using longitudinal in vivo imaging of sparsely labelled microglia, we find a relatively small population of…
Authors not listed
Microglia, the innate immune cells of the central nervous system (CNS), act as first responders in the context of brain injury or neurodegeneration. Their ability to switch between different neuroprotective and neurotoxic phenotypes, plays a central role in maintaining brain homeostasis. Recently, the P2Y12 receptor…
Tiffany Ly, Jeremy G. Thompson, Tajie H. Harris, Scott T. Acton
We propose an automatic 3D segmentation algorithm for multiphoton microscopy images of microglia. Our method is capable of segmenting tubular and blob-like structures from noisy images. Current segmentation techniques and software fail to capture the fine processes and soma of the microglia cells, useful for the study…
Maurizio De Pittà
Glial cells occupy more than a half of the volume of the human brain, and are of several types in the central nervous system (CNS), including astrocytes, oligodendrocytes and microglia [1]. Astrocytes and oligodendrocytes lineage cells are derived from neural stem cells, whereas microglia originate from the immune…
Marc Courchesne, Colin Wakefield, Karen Nygard, Patrick Burns + 4 more
'Gilles Fecteau' 'André Desrochers' 'Mingju Cao' 'Martin G. Frasch'] Biotron, Western University, London, ON, Canada Department of Biology, Western University, London, ON, Canada Drexel University College of Medicine, Philadelphia, PA, USA Dept. of Clinical Sciences, Faculty of Veterinary Medicine, Université de…
Sara Amato, Andrea Arnold
ischemic stroke in the middle cerebral artery Authors: ['Sara Amato' 'Andrea Arnold'] Neuroinflammation immediately follows the onset of ischemic stroke in the middle cerebral artery. During this process, microglial cells are activated in and recruited to the penumbra. Microglial cells can be activated into two…
Maurizio De Pittà
Dependence of neuronal function on glial cells and vice verse, which consists of the interplay of potentially multiple signals that can be both of neuronal and of glial origin. This interplay may be facilitated by the specific arrangement of neurons vs. glia in different brain areas and occurs on time scales extending…
Authors not listed
Exosome-based therapies have emerged as a promising frontier in the field of regenerative medicine, particularly for neural repair. Exosomes, which are microvesicles derived from mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs), exhibit significant regenerative…
Michael M Lübtow, Sabrina Oertner, Sabina Quader, Elisabeth Jeanclos + 11 more
Inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase of the family of statins have been suggested as therapeutic options in various tumors. Atorvastatin is a statin with potential to cross the blood-brain-barrier, however, the concentrations necessary for a cytotoxic effect against cancer cells…
wenzhong liu, hualan li
Infection with the Zika virus results in severe neurological disease in adults or congenital Zika syndrome in newborns. We employed the domain search strategy to study the Zika virus glycoprotein E in this work. The results revealed that immature E contains a NGF domain…