25 papers · ranked by Valyu relevance
Marius Schwabenland, Wolfgang Brück, Josef Priller, Christine Stadelmann + 2 more
'Christine Stadelmann' 'Hans Lassmann' 'Marco Prinz'] As extremely sensitive immune cells, microglia act as versatile watchdogs of the central nervous system (CNS) that tightly control tissue homeostasis. Therefore, microglial activation is an early and easily detectable hallmark of virtually all neuropsychiatric…
N.A. Malinovskaya, O.V. Frolova, K.O. Shishelova, Yu.A. Panina
The role and morphological features of microglia (M1 and M2 microglia, “stellate”, “amoeboid”, giant, round-shaped, rod-shaped, dysfunctional, etc.) in vivo under physiological conditions and during the development of neurodegenerative diseases have been described. Various methods and techniques of microglia isolation…
Jun Qin, Zhihui Ma, Xiaoli Chen, Shiyu Shu
Microglia are the principal resident immune cells in the central nervous system (CNS) and play important roles in the development of CNS disorders. In recent years, there have been significant developments in our understanding of microglia, and we now have greater insight into the temporal and spatial patterns of…
Christopher E. G. Uff, Karishma Patel, Charming Yeung, Ping K. Yip + 1 more
'Eugene D. Ponomarev'] Neuroinflammation has recently been identified as a fundamentally important pathological process in most, if not all, CNS diseases. The main contributor to neuroinflammation is the microglia, which constitute the innate immune response system. Accurate identification of microglia and their…
Li Zong, Pei Chen, Jing Shi, Huijie Chen + 3 more
Viral encephalitis, characterized by inflammation of the brain parenchyma, poses a significant threat to public health due to its high rates of morbidity and mortality. Microglia, the central nervous system’s resident immune cells, are crucial in the pathophysiology and development of this condition. These microglia…
Sarah J. Meller, Lexie Hernandez, Eduardo Martin-Lopez, Teresa Liberia + 1 more
Microglia invade the neuroblast migratory corridor of the rostral migratory stream (RMS) early in development. This work examines how microglia maintain the homeostatic conditions permissive to neuroblast migration in the RMS during the early postnatal period. GFP labeled microglia in CX3CR-1^GFP/+^ mice assemble…
Michael Surala, Luna Soso-Zdravkovic, David Munro, Ali Rifat + 4 more
Microglia, the brain-resident macrophages, are believed to sculpt developing neural circuits by eliminating excess synapses in a process called synaptic pruning, removing apoptotic neurons, and promoting neuronal survival. To elucidate the role of microglia during embryonic and postnatal brain development, we used a…
Emily Maguire, Natalie Connor-Robson, Bethany Shaw, Rachel O’Donoghue + 3 more
'Rachel O’Donoghue' 'Nina Stöberl' 'Hazel Hall-Roberts' 'Giovanni Amabile'] Microglia, the main immune modulators of the central nervous system, have key roles in both the developing and adult brain. These functions include shaping healthy neuronal networks, carrying out immune surveillance, mediating inflammatory…
Shashank Kumar Maurya, Suchi Gupta, Rajnikant Mishra
The emerging role of microglia in brain homeostasis, neurodegeneration, and neurodevelopmental disorders has attracted considerable interest. In addition, recent developments in microglial functions and associated pathways have shed new light on their fundamental role in the immunological surveillance of the brain.…
Daniele Lana, Giada Magni, Elisa Landucci, Gary L. Wenk + 3 more
'Domenico Edoardo Pellegrini-Giampietro' 'Maria Grazia Giovannini' 'Bruno Imbimbo'] Phenomics, the complexity of microglia phenotypes and their related functions compels the continuous study of microglia in disease animal models to find druggable targets for neurodegenerative disorders. Activation of microglia was long…
Marie-France Dorion, Moein Yaqubi, Hunter J. Murdoch, Jeffery A. Hall + 4 more
Efforts to understand microglia function in health and diseases have been hindered by the lack of culture models that recapitulate in situ cellular properties. In recent years, the use of serum-free media with brain-derived growth factors (CSF1R ligands and TGF-β1/2) have been favored for the maintenance of rodent…
Wenxin Ma, Lian Zhao, Biying Xu, Robert N. Fariss + 4 more
Microglia exhibit both maladaptive and adaptive roles in the pathogenesis of neurodegenerative diseases and have emerged as a cellular target for central nervous system (CNS) disorders, including those affecting the retina. Replacing maladaptive microglia, such as those impacted by aging or over-activation, with…
Marc Courchesne, Colin Wakefield, Karen Nygard, Patrick Burns + 4 more
'Gilles Fecteau' 'André Desrochers' 'Mingju Cao' 'Martin G. Frasch'] Biotron, Western University, London, ON, Canada Department of Biology, Western University, London, ON, Canada Drexel University College of Medicine, Philadelphia, PA, USA Dept. of Clinical Sciences, Faculty of Veterinary Medicine, Université de…
Jade Harkin, Cátia Gomes, Kaylee D. Tutrow, Reham Afify + 6 more
Optic neuropathies, including glaucoma, are characterized by the progressive degeneration of retinal ganglion cells (RGCs), ultimately leading to irreversible vision loss. Increasing evidence implicates microglia, the resident immune cells of the central nervous system, as key modulators of RGC health and disease…
Roobina Boghozian, Sorabh Sharma, Manjinder Cheema, Craig E. Brown
Although microglia possess the unique ability to migrate, whether mobility is evident in all microglia, is sex dependent, and what molecular mechanisms drive this, is poorly understood in the adult brain. Using longitudinal in vivo imaging of sparsely labelled microglia, we find a relatively small population of…
Authors not listed
Microglia, the innate immune cells of the central nervous system (CNS), act as first responders in the context of brain injury or neurodegeneration. Their ability to switch between different neuroprotective and neurotoxic phenotypes, plays a central role in maintaining brain homeostasis. Recently, the P2Y12 receptor…
Ahmad, Taha
Background: Patients carrying MEF2C haploinsufficiency develop a clinically recognizable syndrome featuring intellectual disability, difficult-to-control seizures, and autism spectrum behaviors. While we've known for years about this transcription factor's critical roles in heart development and neuronal function, its…
Maurizio De Pittà
Dependence of neuronal function on glial cells and vice verse, which consists of the interplay of potentially multiple signals that can be both of neuronal and of glial origin. This interplay may be facilitated by the specific arrangement of neurons vs. glia in different brain areas and occurs on time scales extending…
Tana S. Pottorf, Elizabeth L. Lane, Zoë Haley-Johnson, Desirée N. Ukmar + 3 more
After nerve injuries, microglia proliferate and migrate towards injured motoneurons, where they attach to the cell bodies. The significance of microglia enwrapping of axotomized motoneurons remains unclear. We found that within the same motor pools, some motoneurons degenerate while others regenerate, and each is…
Miriana Scordino, Giulia Urone, Monica Frinchi, Chiara Valenza + 7 more
Despite the intense research, most therapeutic strategies failed in preventing or treating neurodegenerative diseases, characterized by a combination of chronic neurodegeneration, oxidative stress and neuroinflammation. The broad protective activity of IntegroPectin derived from industrial waste grapefruit peel via…
Sara Amato, Andrea Arnold
ischemic stroke in the middle cerebral artery Authors: ['Sara Amato' 'Andrea Arnold'] Neuroinflammation immediately follows the onset of ischemic stroke in the middle cerebral artery. During this process, microglial cells are activated in and recruited to the penumbra. Microglial cells can be activated into two…
Auddya, Debabrata, Rudraraju, Shiva
Traumatic Brain Injury (TBI) is associated with an impact or concussion to the head with the injury being specifically characterized through pathological degradation at various biological length scales. To quantify the sequence of events following TBI, various mechanical modeling techniques have been proposed in the…
Authors not listed
Exosome-based therapies have emerged as a promising frontier in the field of regenerative medicine, particularly for neural repair. Exosomes, which are microvesicles derived from mesenchymal stem cells (MSCs), neural stem cells (NSCs), and induced pluripotent stem cells (iPSCs), exhibit significant regenerative…
wenzhong liu, hualan li
Infection with the Zika virus results in severe neurological disease in adults or congenital Zika syndrome in newborns. We employed the domain search strategy to study the Zika virus glycoprotein E in this work. The results revealed that immature E contains a NGF domain…
Miriam Bassler, Jonas Hiller, Frank Wackenhut, Sven zur Oven-Krockhaus + 9 more
Malignant primary brain tumors are a group of highly aggressive and often infiltrating tumors that lack adequate therapeutic treatments to achieve long time survival. Complete tumor removal is one precondition to reach this goal. A promising approach to optimize resection margins and eliminate remaining infiltrative…