10 papers · ranked by Valyu relevance
Mikiko Nagashima, Lu Jiang, Sriram Garapati, Thanh Hoang + 1 more
Microglia exhibit substantial molecular and functional heterogeneity, however, how the local tissue environment influences their responses to neuronal injury remains poorly understood. The zebrafish retina provides a unique opportunity to examine this relationship, because in addition to microglia within the retinal…
Ciniso S. Shabangu, Hongjie Chen, Ashokkumar Manickam, Nikesh Katuwal + 7 more
Antiretroviral therapy (ART) effectively suppresses systemic HIV replication but does not eradicate viral reservoirs in the brain, where their identity and contribution to neurological injury remain poorly defined. Using bulk, single-cell, and single-nucleus transcriptomics of postmortem human brain tissue, we identify…
E Kyriakidou, G Cutugno, G Duranthon, P Gaikwad + 32 more
Chronic consumption of energy-dense, high-fat foods persistently exposes hypothalamic circuits that govern body weight to nutrient excess, progressively altering their activity and thereby promoting obesity. Microglia, the brain resident immune cells, sense circulating lipids, but how their intracellular metabolic…
A. Nieto-Quero, J. Munoz-Martin, M. I. Infantes-López, S. Tabbai + 6 more
Effective stress regulation is essential for emotional health, whereas maladaptive stress responses contribute to neuropsychiatric disorders such as depression and post-traumatic stress disorder. Because neuron-microglia interactions are increasingly recognized as key modulators of neuroplasticity under physiological…
Catarina M. Gomes, Gabriela Silva, Mafalda Aleixo, Marta Gomes + 11 more
Gene therapies using adeno-associated viruses (AAVs) for central nervous system (CNS) disorders face challenges because host immune responses are not represented in classical preclinical models. Here, we present a human-induced pluripotent stem cell (hiPSC)-derived innate immunocompetent 3D CNS model that recapitulates…
Jun Zheng, Linxuan Li, Xinchun Jin, Wencao Liu
4## Discussion Appropriate fear responses are adaptive, and disruption of fear memory can lead to an inability to avoid danger (Flores et al. ). Fear memory consolidation can be disrupted by various stimuli, including inflammation. Impaired BBB has been shown to play a role in memory deficit; however, it is not clear…
Nassima Fodil, Esther Del Cid-Pellitero, Valerio E.C. Piscopo, Julia Xiao Xuan Luo + 20 more
Neuroinflammation strongly contributes to the pathogenesis of neurological and neurodegenerative diseases, including Parkinson’s disease (PD). We show that ablation of Usp15 in astrocytes and in microglia protects against lethal neuroinflammation in vivo. In a mouse model of synucleinopathy, Usp15 deletion diminishes…
Shaurav Bhattarai, Emma G. Foster, Rana Kadry, Yaman Lu + 9 more
Quantitative IHC analysis using the 6E10 antibody, specific to human Aβ, was consistent with the ELISA findings. Automated whole-slide image analysis showed no detectable Aβ staining in the control groups (NOG and HIV-1-infected hIL34), whereas substantial amyloid accumulation was present in the cortex and hippocampus…
Lara Gubeljak, Jonas Pes, Eren Arik, Aaron T. Fehr + 5 more
Mast cells (MCs) are widely distributed sentinel cells of the myeloid lineage with substantial migratory capacity. Their activation is initiated by receptor-mediated signaling and culminates in the release of prestored mediators and cytokine secretion, processes tightly controlled by the lipid phosphatase…
Zhi Xu, Jun Chen, Jiayi Yu, Jing Duan + 9 more
The blood-brain barrier (BBB) is increasingly recognized as an active immunoregulatory interface that responds dynamically to systemic inflammation. As intestinal inflammation can influence brain homeostasis through the gut-brain axis, the endogenous mechanisms that preserve BBB integrity during gut-derived…