28 papers · ranked by Valyu relevance
Sakshi Buchke, Muskan Sharma, Anusuiya Bora, Maitrali Relekar + 3 more
'Piyush Bhanu' 'Jitendra Kumar' 'Giorgio Lenaz'] Apart from ATP generation, mitochondria are involved in a wide range of functions, making them one of the most prominent organelles of the human cell. Mitochondrial dysfunction is involved in the pathophysiology of several diseases, such as cancer, neurodegenerative…
Monika Stańczyk, Natalia Szubart, Roman Maslanka, Renata Zadrag-Tecza + 1 more
'Renata Zadrag-Tecza' 'Konstantin Khrapko'] Mitochondria play a crucial role in maintaining the energy status and redox homeostasis of eukaryotic cells. They are responsible for the metabolic efficiency of cells, providing both ATP and intermediate metabolic products. They also regulate cell survival and death under…
Olufemi Akintayo Akinkunmi, Feyikemi Funmilayo Araba, Jessica Adaeze Chukwudebelu, Victor Ademola Adenle + 3 more
Although the mitochondria are known as the cellular powerhouse, their function is beyond energy generation. These organelles regulate cellular metabolism, yet maintains a tightly regulated reactive oxygen species (ROS) generation and optimal redox state. In addition, mitochondria serve as mediators of physiological and…
Tsung-Hsien Chen, Kok-Yean Koh, Kurt Ming-Chao Lin, Chu-Kuang Chou + 1 more
'Peter Bross'] Mitochondria are an important energy source in skeletal muscle. A main function of mitochondria is the generation of ATP for energy through oxidative phosphorylation (OXPHOS). Mitochondrial defects or abnormalities can lead to muscle disease or multisystem disease. Mitochondrial dysfunction can be caused…
Juan M. Suárez-Rivero, Marina Villanueva-Paz, Patricia de la Cruz-Ojeda, Mario de la Mata + 7 more
'Patricia de la Cruz-Ojeda' 'Mario de la Mata' 'David Cotán' 'Manuel Oropesa-Ávila' 'Isabel de Lavera' 'Mónica Álvarez-Córdoba' 'Raquel Luzón-Hidalgo' 'José A. Sánchez-Alcázar' 'Pedro Bullon'] Mitochondria are very versatile organelles in continuous fusion and fission processes in response to various cellular signals.…
Lilin Wang, Xiaoting Zhou, Tianqi Lu
Mitochondria are generally considered essential for life in eukaryotic organisms because they produce most of the energy or adenosine triphosphate (ATP) needed by the cell. Beyond energy production, it is now widely accepted that mitochondria also play a pivotal role in maintaining cellular homeostasis and signaling.…
Ya Li, Huhu Zhang, Chunjuan Yu, Xiaolei Dong + 7 more
Mitochondria are a unique type of semi-autonomous organelle within the cell that carry out essential functions crucial for the cell’s survival and well-being. They are the location where eukaryotic cells carry out energy metabolism. Aside from producing the majority of ATP through oxidative phosphorylation, which…
Haym Benaroya
As neuroscience makes rapid progress in mapping causes and effects at subcellular, cellular, tissue and system levels, the time may be ripe for increased efforts at the mathematical modeling of these causes and effects. Descriptive understanding is extremely valuable, but these tend to be snapshots of coupled and…
Alexander J. Sercel, Gabriel Sturm, Evan D. Shaulson, Dympna Gallagher + 5 more
Mitochondria are key energy transforming organelles in mammalian cells. However, how defects in oxidative phosphorylation (OxPhos) and other mitochondrial functions influence whole-body energy expenditure (EE) has not been rigorously studied. Cellular and organismal responses to OxPhos defects likely involve a…
Alicia N. Campbell, Kendall N. Jung, Steven J. Doyle, Ekaterina Lebayle + 5 more
The Mediator Kinase Module (MKM) coordinates transcriptional programs regulating cellular metabolism, stress responses, and differentiation. Heterozygous variants of MED13L, a core MKM component, cause a neurodevelopmental disorder characterized by variable intellectual disability, developmental delay, neuromuscular…
Nashwa Cheema, Jessie M. Cameron, David A. Hood
Maintaining mitochondrial function and dynamics is crucial for cellular health. In muscle, defects in mitochondria result in severe myopathies where accumulation of damaged mitochondria causes deterioration and dysfunction. Importantly, understanding the role of mitochondria in disease is a necessity to determine…
Michio Sato, Daishi Tanabu, Daisuke Torigoe, Tsuyoshi Kadomatsu + 18 more
Mitochondria play a central role in cellular energy metabolism and homeostasis, and their dysfunction is closely linked to the progression of age-related diseases. The mitochondrial ubiquitin ligase MITOL (also known as MARCHF5) is a key regulator of mitochondrial dynamics and function, and reduced MITOL expression in…
Alexander N. Orekhov, Nikolay A. Orekhov, Vasily N. Sukhorukov, Victoria A. Khotina + 2 more
This review discusses the possibility of inheritance of some diseases through mutations in mitochondrial DNA. These are examples of many mitochondrial diseases that can be caused by mutations in mitochondrial DNA. Symptoms and severity can vary widely depending on the specific mutation and affected tissues. An…
Naibedya Dutta, Joe A Gerke, Sofia F Odron, Joseph D Morris + 19 more
Small molecule inhibitors of the mitochondrial electron transport chain (ETC) hold significant promise to provide valuable insights to the field of mitochondrial research and aging biology. In this study, we investigated two molecules: mycothiazole (MTZ) - from the marine sponge C. mycofijiensis and its more stable…
Hideki Maeda, Daisuke Kami, Ryotaro Maeda, Akira Shikuma + 1 more
Mitochondrial diseases currently have no cure regardless of whether the cause is a nuclear or mitochondrial genome mutation. Mitochondrial dysfunction notably affects a wide range of disorders in aged individuals, including neurodegenerative diseases, cancers, and even senescence. Here, we present a procedure to…
Authors not listed
Fluoroquinolones (FQs) are an important class of potent broad-spectrum antibiotics. However, their general use is more and more limited by adverse side effects. While general mechanisms for the fluoroquinolone-associated disability (FQAD) have been identified, the underlying molecular targets of toxicity remain…
DL McPhie, LW Sargent, SM Babb, D Ben-Shachar + 2 more
Mitochondrial transplantation is currently being explored as a means to repair and restore proper organelle function in a variety of inherited and acquired disorders of energy metabolism. The optimal preparation and application of donor mitochondria is unknown, but most studies in vivo have used injection techniques…
Authors not listed
The intricate bidirectional communication between mitochondria and the gut microbiota – termed mitochondria-microbiome crosstalk – plays a pivotal role in regulating host metabolism, immune responses, and overall physiological homeostasis. Emerging evidence highlights how microbial-derived metabolites, such as…
Aaron B. Morton, Jacob A. Kendra, Brian Glancy, Shadi Golpasandi + 1 more
Mitochondrial dysfunction is well described in many chronic illnesses including musculoskeletal, neurodegenerative, and cardiovascular diseases. Mitochondrial network morphology has been implicated as a biomarker of disease, correlating increased mitochondrial fragmentation to impaired cellular function. While…
Fouzia Kalim, Sivaraman Gandhi, Arati Ramesh, Sufi O. Raja + 1 more
pH dynamically regulates diverse cellular functions and processes. At the Inner Mitochondrial Membrane (IMM), nanoscale pH gradients generated by the Electron Transport Chain (ETC) play a critical role in contributing to mitochondrial membrane potential that drives ATP synthesis and thermogenesis. However, tools to…
Rumiana Tenchov, Janet Sasso, Xinmei Wang, Qiongqiong Angela Zhou
Aging is a dynamic, time-dependent process characterized by a gradual accumulation of cell damage. Continual functional decline in the intrinsic ability of living organisms to accurately regulate homeostasis leads to increased susceptibility and vulnerability to diseases. Anti-aging research has a long history…
Jingsong Zhou, Kamal Dhakal, Jianxun Yi
Muscle uses Ca2+ as a messenger to control contraction and relies on ATP to maintain the intracellular Ca2+ homeostasis. Mitochondria are the major sub-cellular organelle of ATP production. With a negative inner membrane potential, mitochondria take up Ca2+ from their surroundings, a process called mitochondrial Ca2+…
Unmod Senapati, Barsha Priyadarshini Kar, Sunil Pani, Naresh Chandra Bal
Skeletal muscle undergo remarkable changes during aging including anatomical, ultrastructural, and moreover biochemical. The aging associated reduction of muscle mass, termed as sarcopenia, is a major factor in geriatric functional decline and frailty, contributing to the lowering of self-confidence. In an adult…
Rumiana Tenchov, Janet Sasso, Qiongqiong Angela Zhou
Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with abnormally expanded polyglutamine tract. A total of nine polyQ disorders have been identified, including Huntington's disease, six spinocerebellar ataxias…
Irina Kareva
Alzheimer's disease is not the outcome of a single cause but the convergence of many. This review reframes dementia as a systemic failure, where amyloid plaques and tau tangles are not root causes but late-stage byproducts of the underlying metabolic collapse. We begin by tracing the historical merger of early- and…
Αθανάσιος Αλεξίου, Panagiotis Vlamos
Alzheimer's disease is a human brain disease that affects a significant fraction of the population by causing problems with short-term memory, thinking, spatial orientation and behavior, memory loss and other intellectual abilities. Up to date there is no singular test that can definitively diagnose Alzheimer's…
Juvid Aryaman, Iain G. Johnston, Nick S. Jones
Cell-to-cell heterogeneity drives a range of (patho)physiologically important phenomena, such as cell fate and chemotherapeutic resistance. The role of metabolism, and particularly mitochondria, is increasingly being recognised as an important explanatory factor in cell-to-cell heterogeneity. Most eukaryotic cells…
Authors not listed
A steep, age‑related drop in nicotinamide adenine dinucleotide (NAD+) now ranks among the most reproducible molecular signatures of human aging, driving metabolic slowdown, mitochondrial dysfunction, DNA‑repair deficits, chronic inflammation, and stem‑cell fatigue. Boost NAD+ for Anti‑Aging: A Multidimensional Review…