23 papers · ranked by Valyu relevance
Shinichiro Kira, Houman Safaai, Ari S. Morcos, Stefano Panzeri + 1 more
'Christopher D. Harvey'] Decision-making requires flexibility to rapidly switch one’s actions in response to sensory stimuli depending on information stored in memory. We identified cortical areas and neural activity patterns underlying this flexibility during virtual navigation, where mice switched navigation toward…
Grace W. Lindsay, Mattia Rigotti, Melissa R. Warden, Earl K. Miller + 1 more
Complex cognitive behaviors, such as context-switching and rule-following, are thought to be supported by prefrontal cortex (PFC). Neural activity in PFC must thus be specialized to specific tasks while retaining flexibility. Nonlinear ‘mixed’ selectivity is an important neurophysiological trait for enabling complex…
Behnam Karami, Caspar M. Schwiedrzik
Visual objects are often defined by multiple features. Therefore, learning novel objects entails learning conjunctions. Visual cortex is organized into separate compartments, each of which is devoted to processing a single feature. A prime example of this is are neurons purely selective to color and orientation…
Leonard E. van Dyck, Katharina Dobs
Human visual cortex contains regions specialized for faces and bodies, yet we perceive people as a whole. Why does the brain appear to segregate faces and bodies, and how are they integrated to support person perception? Here, we test whether deep neural network models optimized for visual recognition develop…
Alexander O. Malakhov, Vladimir V. Volkov, Anatoly Filippov, Hüseyin Selçuk
'Hüseyin Selçuk'] An approximate model based on friction-coefficient formalism is developed to predict the mixed-gas permeability and selectivity of polymeric membranes. More specifically, the model is a modification of Kedem’s approach to flux coupling. The crucial assumption of the developed model is the division of…
Giuseppe Genduso, Bader S. Ghanem, Ingo Pinnau
The nonideal behavior of polymeric membranes during separation of gas mixtures can be quantified via the solution-diffusion theory from experimental mixed-gas solubility and permeability coefficients. In this study, CO2-CH4 mixtures were sorbed at 35 °C in 4,4′-(hexafluoroisopropylidene)diphthalic dianhydride…
Riccardo Rea, Simone Ligi, Meganne Christian, Vittorio Morandi + 2 more
'Marco Giacinti Baschetti' 'Maria Grazia De Angelis'] We fabricated novel composite (mixed matrix) membranes based on a permeable glassy polymer, Poly(2,6-dimethyl-1,4-phenylene oxide) (PPO), and variable loadings of few-layer graphene, to test their potential in gas separation and CO2 capture applications. The…
Nadine Schmeling, Roman Konietzny, Daniel Sieffert, Patrick Rölling + 2 more
'Claudia Staudt' 'H Ritter'] Functionalized copolyimides continue to attract much attention as membrane materials because they can fulfill the demands for industrial applications. Thus not only good separation characteristics but also high temperature stability and chemical resistance are required. Furthermore, it is…
Authors not listed
CO2-containing synthesis gas is a relevant feedstock for the production of synthetic fuels using Fischer-Tropsch Synthesis. We report the role of CO2 in CO2, CO and H2 mixed feeds over a cobalt-based catalyst at 220 °C and 21 bar in a packed bed reactor. The C5+ selectivity remains above 78 % even for CO2-rich…
Shungo Fujii, Yasunori Ishii, Kazuki Kozuka, Tsubasa Hirakawa + 2 more
'Takayoshi Yamashita' 'Hironobu Fujiyoshi'] Data augmentation is an essential technique for improving recognition accuracy in object recognition using deep learning. Methods that generate mixed data from multiple data sets, such as mixup, can acquire new diversity that is not included in the training data, and thus…
Tianmu Yuan, Maria Grazia De Angelis, Lev Sarkisov
The Robeson bound is a theoretical limit that applies to kinetics-driven membrane separations of gas mixtures. However, this bound does not apply to sorption-driven membrane processes such as CO$_\text{2}$/N$_\text{2}$ separation, which lacks a theoretical explanation. As a result, we are uncertain about the factors…
Authors not listed
Breaking the long-standing permeability–selectivity trade-off remains a central challenge in membrane-based carbon dioxide separations. Here we report a heteroatom-engineering strategy that leverages structurally precise covalent organic frameworks (COFs) to transcend this limitation in mixed matrix membranes (MMMs).…
Vid Ravnik, Urban Bren, Tine Curk
Selective targeting of membranes with a specific receptor profile is an ongoing challenge in targeted drug delivery. We investigate the adsorption of copolymers on a multicomponent receptor-covered surface using grand-canonical Monte Carlo simulations and demonstrate that polymers can be designed to target a particular…
Gergely Becskereki, George Horvai, Blanka Tóth, Xiao Hu
Molecularly imprinted polymers have been shown to be useful in competitive biomimetic binding assays. Recent developments in materials science have further enhanced the capabilities of imprinted polymers. Binding assays, biological and biomimetic alike, owe their usefulness to their selectivity. The selectivity of…
Silvia Acosta-Gutiérrez, Diana Matias, Milagros Avila-Olias, Virginia M. Gouveia + 6 more
Phenotypic targeting requires the ability of the drug delivery system to discriminate over cell populations expressing a particular receptor combination. Such selectivity control can be achieved using multiplexed-multivalent carriers often decorated with multiple ligands. Here, we demonstrate that the promiscuity of a…
Sébastien Boyer, Dipanwita Biswas, Ananda Kumar Soshee, Natale Scaramozzino + 2 more
'Natale Scaramozzino' 'Clément Nizak' 'Olivier Rivoire'] Variation and selection are the core principles of Darwinian evolution, yet quantitatively relating the diversity of a population to its capacity to respond to selection is challenging. Here, we examine this problem at a molecular level in the context of…
Ihuan Gunawan, Moumitha Dey, Daniel P Neumann, Felix V Kohane + 3 more
Multiplexed fluorescence imaging enhances spatially-resolved interrogation of complex, multi-molecular cell processes that are insufficiently sampled using standard 4-5 plex imaging. To improve accessibility and scalability for multiplexed imaging, we demonstrate generative ‘Semantic Multiplexing’ (SemaPlex); a simple…
Elkebir Sarhrouni, Ahmed Hammouch, Driss Aboutajdine
—Hyperspectral images (HSI) classification is a high technical remote sensing software. The purpose is to reproduce a thematic map . The HSI contains more than a hundred hyperspectral measures, as bands (or simply images), of the concerned region. They are taken at neighbors frequencies. Unfortunately, some bands are…
Matthew L. Leavitt, Ari S. Morcos
The properties of individual neurons are often analyzed in order to understand the biological and artificial neural networks in which they're embedded. Class selectivity—typically defined as how different a neuron's responses are across different classes of stimuli or data samples—is commonly used for this purpose.…
Cristina Martínez-Hernández, Mariana del Carmen Aguilera-Puga, Fabien Plisson
Current cancer treatments damage healthy cells and tissues, causing short-term and long-term side effects. New treatments are desired that show greater selectivity toward cancer cells and evade the common mechanisms of multidrug resistance. Membranolytic anticancer peptides (mACPs) hold promise against cancer and…
Leiming Guo, Yong Wang, Martin Steinhart
Removing hazardous particulate and macromolecular contaminants as well as viruses with sizes from a few nm up to the 100-nm-range from water and air is crucial for ensuring sufficient sanitation and hygiene for a growing world population. To this end, high-performance separation membranes are needed that combine high…
Josef Kehrein, Alex Bunker, Robert Luxenhofer
Amphiphilic ABA-triblock copolymers, comprised of poly(2-oxazoline)s and poly(2-oxazine)s, can serve as drug delivery systems; they form micelles that carry poorly water-soluble drugs. Many recent studies have investigated the effect of structural changes of the polymer and the hydrophobic cargo on drug loading. In…
Authors not listed
Mixing is fundamental to chemical processes, ensuring the proximity and interaction of different reactants necessary for a reaction to proceed. A recent report has suggested that stirring may have little impact on reaction outcomes for some solution-phase organic reactions. While such findings may hold under specific…