19 papers · ranked by Valyu relevance
Pierre Barraud, Alexandre Gato, Matthias Heiss, Marjorie Catala + 2 more
Although the biological importance of post-transcriptional RNA modifications in gene expression is widely appreciated, methods to directly detect the introduction of these modifications during RNA biosynthesis are rare and do not easily provide information on the temporal nature of events. Here we introduce the…
Marcel-Joseph Yared, Yasemin Yoluç, Marjorie Catala, Carine Tisné + 2 more
As essential components of the cellular protein synthesis machineries, tRNAs undergo a tightly controlled biogenesis process, which include the incorporation of a large number of posttranscriptional chemical modifications. Maturation defaults resulting in lack of modifications in the tRNA core may lead to the…
Endres Puschner, Maik Ender, Steffen Becker, Christof Paar
Field Programmable Gate Arrays (FPGAs) are known for their reprogrammability that allows for post-manufacture circuitry changes. Nowadays, they are integral to a variety of systems including highsecurity applications such as aerospace and military systems. However, this reprogrammability also introduces significant…
Thapanar Suwanmajo, Vaidhiswaran Ramesh, J. Krishnan
Multisite phosphorylation (and generally multisite modification) is a basic way of encoding substrate function and circuits/networks of post-translational modifications (PTM) are ubiquitous in cell signalling. The information processing characteristics of PTM systems are a focal point of broad interest. The ordering of…
Julia L. Reinsch, David M. Garcia
Saccharomyces cerevisiae is an invaluable model in the study of mitochondrial tRNA biology. Yet the positions of modified bases in all yeast mitochondrially-encoded tRNAs (mt-tRNAs) are still not fully mapped. We performed Nanopore direct RNA sequencing (DRS) on tRNAs from the crude mitochondrial fraction of yeast to…
Julie E Norville, Ratmir Derda, Saurabh Gupta, Kelly A Drinkwater + 3 more
'Angela M Belcher' 'Andres E Leschziner' 'Thomas F Knight Jr'] Background BioBrick standard biological parts are designed to make biological systems easier to engineer (e.g. assemble, manipulate, and modify). There are over 5,000 parts available in the Registry of Standard Biological Parts that can be easily assembled…
Mathias Foo, Rucha Sawlekar, Declan G. Bates
Background Cycles of covalent modification are ubiquitous motifs in cellular signalling. Although such signalling cycles are implemented via a highly concise set of chemical reactions, they have been shown to be capable of producing multiple distinct input-output mapping behaviours - ultrasensitive, hyperbolic…
Dmitry Kostrichkin, С. В. Руденко, Mihails Lapkis, Aigars Atvars
aRD820 Low-Noise Rail-to-Rail Operational Amplifier Authors: ['Dmitry Kostrichkin' 'С. В. Руденко' 'Mihails Lapkis' 'Aigars Atvars'] - The task of this work was to design and later produce a low-power (single supply 5 - 30 V, dual supply ±2.5 V and ±15 V) rail-to-rail operational amplifier aRD820 with low voltage noise…
Han Xin Huang, Gabriella M. Floro, Emmanuel Asare, Weichen Huang + 1 more
Transfer RNA (tRNA) modifications have been increasingly implicated as post-transcriptional regulators of basic neuronal functions. However, characterizing tRNA modification profiles in specific neural circuits that control well-defined behaviors is notoriously difficult due to the complexity of conventional…
Prasad Jayathurathnage, Liu Fu, M. S. Mirmoosa, Xuchen Wang + 2 more
'Romain Fleury' 'Sergei Tretyakov'] Temporal modulation of components of electromagnetic systems provides an exceptional opportunity to engineer the response of those systems in a desired fashion, both in the time and frequency domains. For engineering time-modulated systems, one needs to thoroughly study the basic…
Jake P. Stroud, Mason A. Porter, Guillaume Hennequin, Tim P. Vogels
Motor cortex (M1) exhibits a rich repertoire of activities to support the generation of complex movements. Although recent neuronal-network models capture many qualitative aspects of M1 dynamics, they can generate only a few distinct movements. Additionally, it is unclear how M1 efficiently controls movements over a…
Valerii Ostrovskii, Petr Fedoseev, Yulia Bobrova, Denis Butusov + 1 more
'Xianfu Wang'] This paper proposes a novel identification method for memristive devices using Knowm memristors as an example. The suggested identification method is presented as a generalized process for a wide range of memristive elements. An experimental setup was created to obtain a set of intrinsic I-V curves for…
Jinshui Zhang, Stefan M Goetz
—With their great scalability and flexibility, cascadedbridge and modular multilevel converters have enabled a variety of energy applications, such as offshore wind power, high-voltage dc power transmission, power-quality management, and cuttingedge medical instrumentation. The incorporation of parallel connectivity…
Ruhan Yang, Krithik Ranjan, Ellen Yi–Luen
This paper introduces a new method of paper circuit fabrication that overcomes design barriers and increases flexibility in circuit design. Conventional circuit boards rely on thin traces, which limits the complexity and accuracy when applied to paper circuits. To address this issue, we propose a method that uses large…
Hans C. Ajieren, Andrew G. Fox, Ethan N. Biggs, Gabriel O. Albors + 2 more
Severe side effects prevent the utilization of otherwise promising drugs in treatments. These side effects arise when drugs affect untargeted tissues due to poor target specificity. In photopharmacology, light controls the timing and the location of drug delivery, improving treatment specificity and pharmacokinetic…
Authors not listed
Molecular systems capable of directing the flow of excitons are key to the development and optimization of optoelectronic materials. The transport of excitons across multiple molecules is governed by the intermolecular electronic coupling network. In this manuscript, we consider the effects of complex-valued…
Authors not listed
Iontronics can improve soft robotics, like wearable devices and environmental sensors, by replacing rigid electronics with viscoelastic materials that mimic biological tissue. Circuit components, including diodes, transistors, and power sources, have been fabricated with soft materials that utilize ionic current.…
Authors not listed
RNA molecules fold into complex three-dimensional structures that determine their function. A wide range of mathematical frameworks, such as chord diagrams, fatgraphs, and context-free grammars, have been used to represent these structures; however, these models have largely been developed from mathematical motivations…
Esmaeil Farajpour Bonab, Adam Jaros, Zahra Badri, Lucie Tučková + 2 more
Here, we propose and provide in silico proof of concept of a spinristor; a new molecular electronic component that combines a spin-filter, a rectifier, and a switch, in a single molecule for in-memory processing. It builds on the idea of an open-shell transition metal ion enclosed within an elliptical fullerene…